Fexaramine
- Product Name
- Fexaramine
- CAS No.
- 574013-66-4
- Chemical Name
- Fexaramine
- Synonyms
- CS-1691;Depasan;Actospar;Fexaramine;3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-pr;(E)-methyl 3-(3-(N-((4'-(dimethylamino)biphenyl-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;(E)-methyl 3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;Methyl (E)-3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;Methyl (E)-3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoicacidmethylester
- CBNumber
- CB31074393
- Molecular Formula
- C32H36N2O3
- Formula Weight
- 496.64
- MOL File
- 574013-66-4.mol
Fexaramine Property
- Boiling point:
- 677.7±55.0 °C(Predicted)
- Density
- 1.158±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO : 50 mg/mL (100.68 mM; Need ultrasonic)
- form
- powder
- pka
- 4.95±0.24(Predicted)
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML1390
- Product name
- Fexaramine
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $142
- Updated
- 2023/06/20
- Product number
- SML1390
- Product name
- Fexaramine
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $564
- Updated
- 2023/06/20
- Product number
- 17369
- Product name
- Fexaramine
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 17369
- Product name
- Fexaramine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $122
- Updated
- 2024/03/01
- Product number
- 17369
- Product name
- Fexaramine
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $199
- Updated
- 2024/03/01
Fexaramine Chemical Properties,Usage,Production
Description
The farnesoid X receptor (FXR) is a nuclear receptor that acts as a bile acid sensor, protecting cells and organs against bile acid toxicity and coordinating cholesterol metabolism, lipid homeostasis, and absorption of dietary fats and vitamins. Fexaramine is an FXR agonist (EC50 = 25 nM) that demonstrates 100-fold increased affinity to FXR compared to endogenous bile acids and 3-fold increased potency compared to the high affinity FXR agonist GW 4064 (; EC50 = 80 nM). Fexaramine does not display activity at the following nuclear receptors: hRXRα, hPPARαγδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ, or hVDR.
Uses
Fexaramine has been used to study its action on RANKL (receptor activator of nuclear factor-κB ligand)-induced osteoclastogenesis in mouse model.
Definition
ChEBI: Fexaramine is a member of biphenyls.
General Description
Fexaramine belongs to the nuclear hormone receptor family.
Biological Activity
Potent, selective farnesoid X receptor agonist (EC 50 = 25 nM). Displays no activity at hRXR α , hPPAR α , hPPAR γ , hPPAR δ , mPXR, hPXR, hLXR α , hTR β , hRAR β , mCAR, mERR γ and hVDR receptors.
Biochem/physiol Actions
Fexaramine might regulate lipid and glucose metabolism and can serve as a therapeutic target in the treatment of fatty liver disease, type 2 diabetes and obesity. Fexaramine might mediate cholesterol homeostasis and promotes osteoblast differentiation and suppresses differentiation of osteoclast.
storage
Desiccate at +4°C
Fexaramine Preparation Products And Raw materials
Raw materials
Preparation Products
Fexaramine Suppliers
View Lastest Price from Fexaramine manufacturers
- Product
- Fexaramine 574013-66-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20kg
- Release date
- 2019-09-05