5-Pyrimidinemethanol, 2-amino- (9CI)
- Product Name
- 5-Pyrimidinemethanol, 2-amino- (9CI)
- CAS No.
- 120747-85-5
- Chemical Name
- 5-Pyrimidinemethanol, 2-amino- (9CI)
- Synonyms
- 2-Aminopyrimidine-5-methanol;2-AMINO-55PYRIMIDINEMETHANOL;2-Amino-5-pyrimidinemethanol;5-Pyrimidinemethanol, 2-amino-;(2-AMino-pyriMidin-5-yl)-Methanol;5-Pyrimidinemethanol, 2-amino- (9CI);5-Pyrimidinemethanol, 2-amino- (9CI) ISO 9001：2015 REACH
- CBNumber
- CB31082266
- Molecular Formula
- C5H7N3O
- Formula Weight
- 125.13
- MOL File
- 120747-85-5.mol
5-Pyrimidinemethanol, 2-amino- (9CI) Property
- Boiling point:
- 396.3±34.0 °C(Predicted)
- Density
- 1.360±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 13.36±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A629420
- Product name
- (2-Aminopyrimidin-5-yl)methanol
- Packaging
- 500mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 3624AA
- Product name
- (2-Aminopyrimidin-5-yl)methanol
- Packaging
- 1g
- Price
- $277
- Updated
- 2021/12/16
- Product number
- OR345712
- Product name
- (2-Aminopyrimidin-5-yl)methanol
- Packaging
- 1g
- Price
- $358
- Updated
- 2021/12/16
- Product number
- 4H58-1-620
- Product name
- (2-Aminopyrimidin-5-yl)methanol
- Packaging
- 1g
- Price
- $424
- Updated
- 2021/12/16
- Product number
- CHM0093401
- Product name
- 2-AMINO-5-PYRIMIDINEMETHANOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.76
- Updated
- 2021/12/16
5-Pyrimidinemethanol, 2-amino- (9CI) Chemical Properties,Usage,Production
Synthesis
120747-84-4
120747-85-5
General procedure for the synthesis of (2-aminopyrimidin-5-yl)methanol from 2-amino-5-pyrimidinecarboxaldehyde: To a stirred solution of 2-amino-5-pyrimidinecarboxaldehyde (500 mg, 4.06 mmol) in methanol (6 mL) was added sodium borohydride (200 mg, 5.28 mmol) in batches. The reaction mixture was slowly warmed up to 0 °C, followed by returning to room temperature and continued stirring for 3 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) (unfolding agent: dichloromethane solution in 5% methanol, Rf value 0.3). Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous ammonium chloride solution and the mixture was concentrated under reduced pressure. The residue was directly upsampled onto a short silica gel column (100-200 mesh) and eluted using a gradient from dichloromethane to a dichloromethane solution containing 7.5% methanol. The eluate containing the target product was collected and concentrated to give (2-aminopyrimidin-5-yl)methanol as a light yellow solid (340 mg, 67% yield). The product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 8.16 (s, 2H), 6.50 (br s, 2H), 4.99 (t, 1H), 4.26 (d, 2H).GCMS (m/z): 125.0.
References
[1] Patent: WO2016/193844, 2016, A1. Location in patent: Page/Page column 104
[2] Patent: US2005/187219, 2005, A1. Location in patent: Page/Page column 17
[3] Patent: WO2004/22561, 2004, A1. Location in patent: Page 94
[4] Patent: WO2004/831, 2003, A1. Location in patent: Page 24
[5] Patent: US2009/226398, 2009, A1
5-Pyrimidinemethanol, 2-amino- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
5-Pyrimidinemethanol, 2-amino- (9CI) Suppliers
- Tel
- --
- Fax
- --
- info@chemstep.com
- Country
- Europe
- ProdList
- 6143
- Advantage
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View Lastest Price from 5-Pyrimidinemethanol, 2-amino- (9CI) manufacturers
- Product
- 5-Pyrimidinemethanol, 2-amino- (9CI) 120747-85-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-14
- Product
- 5-Pyrimidinemethanol, 2-amino- (9CI) 120747-85-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09