2-AMINO-5-CARBOETHOXY-4-HYDROXYPYRIMIDINE
- Product Name
- 2-AMINO-5-CARBOETHOXY-4-HYDROXYPYRIMIDINE
- CAS No.
- 15400-53-0
- Chemical Name
- 2-AMINO-5-CARBOETHOXY-4-HYDROXYPYRIMIDINE
- Synonyms
- Einecs 239-418-5;LABOTEST-BB LT00455352;Oxetane,6-[(phenylsulfonyl)methylene]-;2-Amino-5-carboethoxy-4-hydroxyprimidine;Silanecarboxamide,N,N,1,1,6-pentamethyl-;2-AMINO-5-CARBOETHOXY-4-HYDROXYPYRIMIDINE;2-Amino-5-carbethoxyl-4-hydroxypyrimidine;2-AMino-5-carbethoxy-4-hydroxy pyriMidine;2-Amino-5-ethoxycarbonyl-4-hydroxypyrimidine;ETHYL 2-AMINO-4-HYDROXYPYRIMIDINE-5-CARBOXYLATE
- CBNumber
- CB3113079
- Molecular Formula
- C7H9N3O3
- Formula Weight
- 183.16
- MOL File
- 15400-53-0.mol
2-AMINO-5-CARBOETHOXY-4-HYDROXYPYRIMIDINE Property
- Melting point:
- 300°C (dec.)
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- powder to crystal
- pka
- 8.26±0.50(Predicted)
- color
- White to Orange to Green
- BRN
- 165835
- InChIKey
- HRRHGLKNOJHIGY-UHFFFAOYSA-N
- CAS DataBase Reference
- 15400-53-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S423475
- Product name
- ETHYL 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXYLATE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $113
- Updated
- 2025/07/31
- Product number
- S423475
- Product name
- ETHYL 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXYLATE
- Purity
- Aldrich
- Packaging
- 50mg
- Price
- $110
- Updated
- 2024/03/01
- Product number
- E1247
- Product name
- Ethyl 2-Amino-4-hydroxypyrimidine-5-carboxylate
- Packaging
- 1G
- Price
- $64
- Updated
- 2025/07/31
- Product number
- E1247
- Product name
- Ethyl 2-Amino-4-hydroxypyrimidine-5-carboxylate
- Packaging
- 5G
- Price
- $221
- Updated
- 2025/07/31
- Product number
- B433920
- Product name
- Ethyl 2-Amino-4-hydroxypyrimidine-5-carboxylate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
2-AMINO-5-CARBOETHOXY-4-HYDROXYPYRIMIDINE Chemical Properties,Usage,Production
Definition
ChEBI: An aminopyrimidine that is 2-amino-4-hydroxypyrimidine in which the hydrogen at position 5 is substituted by an ethoxycarbonyl group.
Synthesis
124-46-9
87-13-8
15400-53-0
In a 20 L three-necked flask, 1.070 Kg of potassium hydroxide (KOH) was dissolved in 10 L of distilled water and stirred until completely dissolved to form a clarified solution. Subsequently, 5 g of silica-functionalized magnetic nanoparticles (Fe3O4@SiO2) were added to the solution. Under continuous stirring, 2 Kg of guanidine carbonate was added to the above mixture to ensure its complete dissolution. The temperature of the reaction system was maintained at around 20°C. Over a period of 3 hours, 2.4 kg of diethyl ethoxymethyl malonate was slowly added dropwise while the reaction temperature was gradually increased from 20 °C to 35 °C. A yellow solid precipitated during the reaction and the reaction mixture was subsequently cooled. The Fe3O4@SiO2 particles were separated and removed using an external magnet and the particles were washed with acetone and dried. The reaction mixture was further cooled to 0-5°C and filtered to obtain a light yellow consistency, which was washed well with ice water. The crude product was recrystallized by ethanol/water solvent mixture and dried in an oven at 40°C. The dried product was divided into two parts and dissolved in 15 L of 60% water/40% ethanol mixed solvent for secondary recrystallization. The initial recrystallized solution was turbid and was clarified by steam heating for 1 hour. Subsequently, the solution began to crystallize at 39°C and was slowly cooled to room temperature. The above recrystallization process was repeated for both parts of the product and the final product was dried in a vacuum oven. Yield: 95%.
References
[1] Asian Journal of Chemistry, 2017, vol. 29, # 10, p. 2119 - 2122
[2] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 14, p. 4841 - 4856
[3] Patent: US6194419, 2001, B1
2-AMINO-5-CARBOETHOXY-4-HYDROXYPYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-AMINO-5-CARBOETHOXY-4-HYDROXYPYRIMIDINE manufacturers
- Product
- 2-AMino-5-carboethoxy-4-hydroxypyriMidine 15400-53-0
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50ton
- Release date
- 2020-05-19
- Product
- 2-AMINO-5-CARBOETHOXY-4-HYDROXYPYRIMIDINE 15400-53-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-09
- Product
- Ethyl 2-amino-4-hydroxypyrimidine-5-carboxylate 15400-53-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-14