2-Pyrimidinamine, 5-methyl- (9CI)
- Product Name
- 2-Pyrimidinamine, 5-methyl- (9CI)
- CAS No.
- 50840-23-8
- Chemical Name
- 2-Pyrimidinamine, 5-methyl- (9CI)
- Synonyms
- 5-methylpyrimidin-2-amine;5-Methyl-2-pyrimidinamine;2-amino-5-methylpyrimidine;5-Methyl-2-aminopyrimidine;5-Methylpyrimidine-2-amine;2-PyriMidinaMine, 5-Methyl-;5-Methyl-pyrimidin-2-ylamine;Pyrimidine, 2-amino-5-methyl-;2-Pyrimidinamine, 5-methyl- (9CI);2-Pyrimidinamine, 5-methyl- (9CI) ISO 9001：2015 REACH
- CBNumber
- CB41081352
- Molecular Formula
- C5H7N3
- Formula Weight
- 109.13
- MOL File
- 50840-23-8.mol
2-Pyrimidinamine, 5-methyl- (9CI) Property
- Melting point:
- 192-193℃
- Boiling point:
- 194.6°C (rough estimate)
- Density
- 1.155
- refractive index
- 1.5340 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- solid
- pka
- 4.20±0.10(Predicted)
- Appearance
- White to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CDS009715
- Product name
- 5-methylpyrimidin-2-amine
- Purity
- AldrichCPR
- Packaging
- 100mg
- Price
- $172
- Updated
- 2023/01/07
- Product number
- M338000
- Product name
- 5-Methylpyrimidin-2-amine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 072626
- Product name
- 2-Amino-5-methylpyrimidine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $559
- Updated
- 2021/12/16
- Product number
- 072626
- Product name
- 2-Amino-5-methylpyrimidine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $260
- Updated
- 2021/12/16
- Product number
- OR951919
- Product name
- 5-Methylpyrimidin-2-amine
- Purity
- 95%
- Packaging
- 1g
- Price
- $360
- Updated
- 2021/12/16
2-Pyrimidinamine, 5-methyl- (9CI) Chemical Properties,Usage,Production
Uses
5-Methylpyrimidin-2-amine is a useful research chemical compound used in the preparation of highly potent macrocyclic ALK inhibitors as potential antitumors.
Synthesis
22536-61-4
50840-23-8
Step 1: 2-Chloro-5-methylpyrimidine (10.0 g, 77.79 mmol) was dissolved in industrial methanol (IMS, 100 mL) followed by addition of 35% ammonia (100 mL). The reaction mixture was transferred to an autoclave, sealed and reacted at 200 °C for 4 hours. Upon completion of the reaction, it was cooled to room temperature and most of the solvent was removed by concentration via rotary evaporator. Water (25 mL) was added to the residue and a solid was precipitated. The solid was collected by filtration and dried under vacuum to afford 2-amino-5-methylpyrimidine (7.85 g, 92% yield) as an off-white solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.06 (s, 2H), 6.30 (s, 2H), 2.03 (s, 3H).LCMS analysis showed m/z 110 [M + H]+.
Purification Methods
Crystallise it from water or *benzene/pet ether and sublime it at 50o/0.5mm. [Beilstein 24 H 87.]
References
[1] Patent: WO2013/132376, 2013, A1. Location in patent: Page/Page column 205
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 11, p. 4720 - 4744
[3] Chemische Berichte, 1905, vol. 38, p. 3397
[4] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 5, p. 1261 - 1266
2-Pyrimidinamine, 5-methyl- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Pyrimidinamine, 5-methyl- (9CI) manufacturers
- Product
- 2-Pyrimidinamine, 5-methyl- (9CI) 50840-23-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-07
- Product
- 2-Pyrimidinamine, 5-methyl- (9CI) 50840-23-8
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02