ChemicalBook > CAS DataBase List > 2-Pyrimidinamine, 5-methyl- (9CI)

2-Pyrimidinamine, 5-methyl- (9CI)

Product Name: 2-Pyrimidinamine, 5-methyl- (9CI)
CAS No.: 50840-23-8
Chemical Name: 2-Pyrimidinamine, 5-methyl- (9CI)
Synonyms: 5-methylpyrimidin-2-amine;5-Methyl-2-pyrimidinamine;2-amino-5-methylpyrimidine;5-Methyl-2-aminopyrimidine;5-Methylpyrimidine-2-amine;2-PyriMidinaMine, 5-Methyl-;5-Methyl-pyrimidin-2-ylamine;Pyrimidine, 2-amino-5-methyl-;2-Pyrimidinamine, 5-methyl- (9CI);2-Pyrimidinamine, 5-methyl- (9CI) ISO 9001：2015 REACH
CBNumber: CB41081352
Molecular Formula: C5H7N3
Formula Weight: 109.13
MOL File: 50840-23-8.mol

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2-Pyrimidinamine, 5-methyl- (9CI) Property

Melting point:: 192-193℃
Boiling point:: 194.6°C (rough estimate)
Density: 1.155
refractive index: 1.5340 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: solid
pka: 4.20±0.10(Predicted)
Appearance: White to yellow Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS009715
Product name: 5-methylpyrimidin-2-amine
Purity: AldrichCPR
Packaging: 100mg
Price: $172
Updated: 2023/01/07

TRC

Product number: M338000
Product name: 5-Methylpyrimidin-2-amine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: W6602
Product name: 2-Amino-5-methylpyrimidine
Packaging: 100mg
Price: $87
Updated: 2021/12/16

Matrix Scientific

Product number: 072626
Product name: 2-Amino-5-methylpyrimidine
Purity: 95+%
Packaging: 250mg
Price: $260
Updated: 2021/12/16

Apolloscientific

Product number: OR951919
Product name: 5-Methylpyrimidin-2-amine
Purity: 95%
Packaging: 1g
Price: $360
Updated: 2021/12/16

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2-Pyrimidinamine, 5-methyl- (9CI) Chemical Properties,Usage,Production

Uses

5-Methylpyrimidin-2-amine is a useful research chemical compound used in the preparation of highly potent macrocyclic ALK inhibitors as potential antitumors.

Synthesis

22536-61-4

50840-23-8

Step 1: 2-Chloro-5-methylpyrimidine (10.0 g, 77.79 mmol) was dissolved in industrial methanol (IMS, 100 mL) followed by addition of 35% ammonia (100 mL). The reaction mixture was transferred to an autoclave, sealed and reacted at 200 °C for 4 hours. Upon completion of the reaction, it was cooled to room temperature and most of the solvent was removed by concentration via rotary evaporator. Water (25 mL) was added to the residue and a solid was precipitated. The solid was collected by filtration and dried under vacuum to afford 2-amino-5-methylpyrimidine (7.85 g, 92% yield) as an off-white solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.06 (s, 2H), 6.30 (s, 2H), 2.03 (s, 3H).LCMS analysis showed m/z 110 [M + H]+.

Purification Methods

Crystallise it from water or *benzene/pet ether and sublime it at 50o/0.5mm. [Beilstein 24 H 87.]

References

[1] Patent: WO2013/132376, 2013, A1. Location in patent: Page/Page column 205
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 11, p. 4720 - 4744
[3] Chemische Berichte, 1905, vol. 38, p. 3397
[4] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 5, p. 1261 - 1266

2-Pyrimidinamine, 5-methyl- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Pyrimidinamine, 5-methyl- (9CI) manufacturers

Dideu Industries Group Limited

Product: 2-Pyrimidinamine, 5-methyl- (9CI) 50840-23-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-07

Career Henan Chemical Co

Product: 2-Pyrimidinamine, 5-methyl- (9CI) 50840-23-8
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

50840-23-8, 2-Pyrimidinamine, 5-methyl- (9CI)Related Search:

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2-Pyrimidinamine, 5-methyl- (9CI)

5-methylpyrimidin-2-amine

2-amino-5-methylpyrimidine

5-Methyl-2-pyrimidinamine

5-Methylpyrimidine-2-amine

5-Methyl-2-aminopyrimidine

2-PyriMidinaMine, 5-Methyl-

5-Methyl-pyrimidin-2-ylamine

Pyrimidine, 2-amino-5-methyl-

2-Pyrimidinamine, 5-methyl- (9CI) ISO 9001：2015 REACH

50840-23-8

Heterocycle-Pyrimidine series

PYRIMIDINE