5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine

Product Name: 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
CAS No.: 6981-18-6
Chemical Name: 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine
Synonyms: OMP;NSC3272;Omeprin;NSC 3272;NSC-3272;NSC-95072;Ro 5-9754;ORMETOPRIN;ORMETOPRIM;ORMETHOPRIM
CBNumber: CB6333201
Molecular Formula: C14H18N4O2
Formula Weight: 274.32
MOL File: 6981-18-6.mol

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5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Property

Melting point:: 231.0 to 235.0 °C
Boiling point:: 521.5±60.0 °C(Predicted)
Density: 1.223±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 7.11±0.10(Predicted)
color: Off-White
Water Solubility: Water: Insoluble
λmax: 287nm(CHCl3)(lit.)
Stability:: Hygroscopic
CAS DataBase Reference: 6981-18-6(CAS DataBase Reference)
EPA Substance Registry System: Ormetoprim (6981-18-6)

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Safety

Safety Statements: 24/25
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: O0424
Product name: Ormetoprim
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $162
Updated: 2021/12/16

TCI Chemical

Product number: O0424
Product name: Ormetoprim
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $562
Updated: 2021/12/16

TRC

Product number: O686800
Product name: Ormetoprim
Packaging: 1g
Price: $130
Updated: 2021/12/16

Usbiological

Product number: O7049
Product name: Ormetoprim
Packaging: 500ul
Price: $280
Updated: 2021/12/16

Usbiological

Product number: 227106
Product name: Ormetoprim
Packaging: 500ul
Price: $360
Updated: 2021/12/16

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5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Chemical Properties,Usage,Production

Uses

It is a potent and selective inhibitor of bacterial dihydrofolate reductase, the enzyme responsible for the NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. Antibacterial.This compound is a contaminant of emerging concern (CECs).

Definition

ChEBI: 5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine is a dimethoxybenzene.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 14, p. 462, 1971 DOI: 10.1021/jm00287a029

in vivo

Ormetoprim (8.3 mg/kg; i.p.) exhibits absorption half-life (5.4 h), elimination half-life (7.5 h) and C_max (1.2±0.2 μg/mL)^[3].
Ormetoprim (8.3 mg/kg; p.o.) exhibits absorption half-life (3.9 h), elimination half-life (3.9 h), C_max (1.6±0.4 μg/mL) and oral availability (78.5%) relative to intraperitoneal administration^[3].

Animal Model:	Hybrid striped bass (565-805 g)^[3]
Dosage:	50 mg/kg Sulfadimethoxine and Ormetoprim in a 5:1 ratio (Pharmacokinetic Analysis)
Administration:	I.p. and p.o. administration
Result:	I.p.: t_1/2(elim)=7.5 h; t_1/2(abs)=5.4 h; C_max=1.2 μg/mL. P.o.: t_1/2(elim)=3.9 h; t_1/2(abs)=3.9 h; C_max=1.6 μg/mL; F=78.5%.

5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine Suppliers

Americas 1 Canada 1 China 137 Czech Republic 1 Germany 3 India 5 Japan 1 United Kingdom 7 United States 23 Global 179

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View Lastest Price from 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Ormetoprim 6981-18-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98
Supply Ability: 10000KGS
Release date: 2025-11-18

Shaanxi Dideu Medichem Co. Ltd

Product: ORMETOPRIM 6981-18-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%+
Supply Ability: 2000 kgs
Release date: 2025-09-13

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Ormetoprim 6981-18-6
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kgs
Release date: 2021-10-15

6981-18-6, 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidineRelated Search:

DIBENZYL SULFOXIDE 2-Methylindole Benzylacetone Tetramethylammonium chloride N,N-Dimethylformamide Pyrimidine 2-Pyrimidinamine, 5-methyl- (9CI) Diaveridine 5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4- diamine 5-ETHYL-2-PYRIMIDINAMINE 2,4-Diamino-5-(4-methoxybenzyl)pyrimidine 2,4-Diamino-5-(3-methoxybenzyl)pyrimidine 5-Benzyl-2,4-diaminopyrimidine 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine

ORMETHOPRIM

ORMETOPRIM

ORMETOPRIN

OMP

5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine

L-Ascorbic Phosphate Magnesium

2,4-DiaMino-5-92-Methyl-4,5- diMethoxybenzyl)pyriMidine

DiaMino-5-(6-Methylveratryl)pyriMidine

2,4-Diamino-5-(6-methylveratryl)pyrimidine

5-(4,5-Dimethoxy-2-methylbenzyl)pyrimidine-2,4-diamine

NSC-95072

Ro 5-9754

5-[(4,5-Dimethoxy-2-methyl)phenylmethyl]-2,4-pyrimidine

5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine

Ormetoprim Standard

Ormetoprim&gt

2,4-Pyrimidinediamine, 5-[(4,5-dimethoxy-2-methylphenyl)methyl]-

2,4-Diamino-5-(4,5-dimethoxy-2-methylbenzyl)pyrimidine

5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine USP/EP/BP

6981-18-6 5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine

N'-Diphenylguanidine

NSC 3272

NSC3272

NSC-3272

Omeprin

Ormetoprim, 10 mM in DMSO

Ormetoprim - Bio-X ?

Ormetoprim 100 μg/mL in Acetonitrile

6981-18-6

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