2-Aminopyrimidine-5-carboxylic acid
- Product Name
- 2-Aminopyrimidine-5-carboxylic acid
- CAS No.
- 3167-50-8
- Chemical Name
- 2-Aminopyrimidine-5-carboxylic acid
- Synonyms
- ASISCHEM C63548;2-Aminopyrimidine-5-carboxyL;2-Aminopyrimidin-5-carboxylic acid;2-AMINOPYRIMIDINE-5-CARBOXYLIC ACID;2-AMino-5-pyriMidinecarboxylic acid;2-Aminopyrimidine-5-carboxylicacid95%;5-Pyrimidinecarboxylic acid, 2-amino-;2-Aminopyrimidine-5-carboxylic acid ,97%;2-Aminopyrimidine-5-carboxylic acid USP/EP/BP;5-Pyrimidinecarboxylic acid, 2-amino- (7CI,8CI,9CI)
- CBNumber
- CB9330403
- Molecular Formula
- C5H5N3O2
- Formula Weight
- 139.11
- MOL File
- 3167-50-8.mol
2-Aminopyrimidine-5-carboxylic acid Property
- Melting point:
- >300 °C
- Boiling point:
- 474.6±37.0 °C(Predicted)
- Density
- 1.533±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 4.19±0.10(Predicted)
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C5H5N3O2/c6-5-7-1-3(2-8-5)4(9)10/h1-2H,(H,9,10)(H2,6,7,8)
- InChIKey
- CBRLWSXYXSFYSP-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=C(C(O)=O)C=N1
- CAS DataBase Reference
- 3167-50-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 36/37-24/25-22
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A629338
- Product name
- 2-Aminopyrimidine-5-carboxylicAcid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A629338
- Product name
- 2-Aminopyrimidine-5-carboxylicAcid
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- J55997
- Product name
- 2-Amino-5-pyrimidinecarboxylicacid
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 4H57-1-Z8
- Product name
- 2-Aminopyrimidine-5-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $42
- Updated
- 2021/12/16
- Product number
- 071793
- Product name
- 2-Aminopyrimidine-5-carboxylic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $48
- Updated
- 2021/12/16
2-Aminopyrimidine-5-carboxylic acid Chemical Properties,Usage,Production
Reactivity Profile
Decarboxylative Csingle bondC cross-couplings of 2-aminopyrimidine-5-carboxylic acids under a Pd/Ag-based catalytic system opens a new platform for introducing diverse C5 substituents. The reaction methods proceeded efficiently with various acids and the coupling partners of aryl iodides, alkenes, bromoalkynes, and azoles.
Synthesis
308348-93-8
3167-50-8
General procedure for the synthesis of 2-aminopyrimidine-5-carboxylic acid from methyl 2-aminopyrimidine-5-carboxylate: methyl 2-aminopyrimidine-5-carboxylate (300 mg, 2.0 mmol) was dissolved in methanol (5 mL) containing a small amount of water. Lithium hydroxide (122 mg, 5.1 mmol) was added to the solution and the reaction mixture was subsequently stirred at 60 °C overnight. Upon completion of the reaction, the mixture was concentrated under reduced pressure, and the residue was diluted with water and the pH was adjusted to 4 with 1 M HCl solution.At this point, 2-aminopyrimidine-5-carboxylic acid precipitated as a white solid, and the product was collected by filtration under vacuum to give 244 mg in 90% yield. The product was characterized by 1H NMR (DMSO-d6): δ 12.73 (1H, broad peak), 8.63 (2H, single peak), 7.44 (2H, broad peak).
References
[1] Ngoc Son Le Pham . “Decarboxylative cross-couplings of 2-aminopyrimidine-5-carboxylic acids.” Tetrahedron 74 28 (2018): Pages 3843-3851.
2-Aminopyrimidine-5-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Aminopyrimidine-5-carboxylic acid manufacturers
- Product
- 2-Aminopyrimidine-5-carboxylic acid 3167-50-8
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-08
- Product
- 2-Aminopyrimidine-5-carboxylic acid 3167-50-8
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10MT
- Release date
- 2018-12-19