2(1H)-Pyridinone, 5-acetyl- (9CI)
- Product Name
- 2(1H)-Pyridinone, 5-acetyl- (9CI)
- CAS No.
- 1124-29-4
- Chemical Name
- 2(1H)-Pyridinone, 5-acetyl- (9CI)
- Synonyms
- 5-Acetylpyridin-2(1H);5-acetyl-2(1H)-Pyridinone;5-Acetylpyridin-2(1H)-one;5-acetyl-1H-pyridin-2-one;5-Acetyl-2-hydroxypyridine;2(1H)-Pyridinone, 5-acetyl-;3-Acethyl-6-hydroxypyridine;1-(6-Hydroxypyridin-3-yl)ethanone;2(1H)-Pyridinone, 5-acetyl- (9CI);1-(6-hydroxypyridin-3-yl)ethan-1-one
- CBNumber
- CB31082640
- Molecular Formula
- C7H7NO2
- Formula Weight
- 137.14
- MOL File
- 1124-29-4.mol
2(1H)-Pyridinone, 5-acetyl- (9CI) Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- color
- Pale yellow
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B433928
- Product name
- 1-(6-Hydroxypyridin-3-yl)ethanone
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR903475
- Product name
- 2-Hydroxy-5-acetylpyridine
- Packaging
- 1g
- Price
- $64
- Updated
- 2021/12/16
- Product number
- OR903475
- Product name
- 2-Hydroxy-5-acetylpyridine
- Packaging
- 5g
- Price
- $189
- Updated
- 2021/12/16
- Product number
- X9010
- Product name
- 1-(6-Hydroxypyridin-3-yl)ethanone
- Packaging
- 5g
- Price
- $288
- Updated
- 2021/12/16
- Product number
- X9010
- Product name
- 1-(6-Hydroxypyridin-3-yl)ethanone
- Packaging
- 10g
- Price
- $450
- Updated
- 2021/12/16
2(1H)-Pyridinone, 5-acetyl- (9CI) Chemical Properties,Usage,Production
Synthesis
213193-32-9
1124-29-4
1. 2-Methoxy-5-acetylpyridine (1.51 g, 10 mmol) was mixed with 6 N hydrochloric acid solution and reacted at 100 °C for 5 hours. 2. After completion of the reaction, the reaction mixture was neutralized with sodium hydroxide solution to pH 7, followed by multiple extractions with dichloromethane. 3. The organic layers were combined, dried with anhydrous sodium sulfate, concentrated under reduced pressure and the residue was recrystallized by ethyl acetate to afford 5-acetyl-2(1H)-pyridinone as a white solid (1.06 g, 78% yield). 4. The above product (685.7 mg, 5 mmol) was mixed with iodobenzene (0.84 mL, 7.5 mmol), cuprous iodide (95 mg, 0.5 mmol), and potassium carbonate (691 mg, 5 mmol) in N,N-dimethylformamide (5 mL), and reacted at 135 °C overnight. 5. At the end of the reaction, the reaction mixture was diluted with 10% ammonia solution (15 mL) and extracted with ethyl acetate. 6. The organic layer was washed with saturated sodium chloride solution, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. 7. Purification by column chromatography (eluent: 10% ethyl acetate/dichloromethane) afforded 5-acetyl-2(1H)-pyridinone as a white solid (407 mg, 38% yield). 8. The 1H NMR spectrum of the product was consistent with the structure of target compound 16.
References
[1] Patent: WO2006/122154, 2006, A2. Location in patent: Page/Page column 64
[2] Patent: US2014/94456, 2014, A1. Location in patent: Paragraph 0558; 0560
[3] Patent: WO2015/153683, 2015, A1. Location in patent: Paragraph 0314
2(1H)-Pyridinone, 5-acetyl- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
2(1H)-Pyridinone, 5-acetyl- (9CI) Suppliers
- Tel
- --
- Fax
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- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
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View Lastest Price from 2(1H)-Pyridinone, 5-acetyl- (9CI) manufacturers
- Product
- 2(1H)-Pyridinone, 5-acetyl- (9CI) 1124-29-4
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-26
- Product
- 2(1H)-Pyridinone, 5-acetyl- (9CI) 1124-29-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-28
- Product
- 2(1H)-Pyridinone, 5-acetyl- (9CI) 1124-29-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-08