2-BROMONICOTINIC ACID ETHYL ESTER
- Product Name
- 2-BROMONICOTINIC ACID ETHYL ESTER
- CAS No.
- 53087-78-8
- Chemical Name
- 2-BROMONICOTINIC ACID ETHYL ESTER
- Synonyms
- Ethyl 2-bromonicotinate;Ethyl2-bromonicotinate,96%;ethyl 2-broMopyridine-3-carboxylate;2-bromo-3-pyridinecarboxylic acid ethyl ester;3-Pyridinecarboxylic acid, 2-bromo-, ethyl ester
- CBNumber
- CB31091813
- Molecular Formula
- C8H8BrNO2
- Formula Weight
- 230.06
- MOL File
- 53087-78-8.mol
2-BROMONICOTINIC ACID ETHYL ESTER Property
- Boiling point:
- 271℃
- Density
- 1.501
- Flash point:
- 118℃
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -1.14±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- E903443
- Product name
- Ethyl2-Bromonicotinate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 126618
- Product name
- Ethyl2-bromonicotinate
- Purity
- >95%
- Packaging
- 5g
- Price
- $1224
- Updated
- 2021/12/16
- Product number
- 126618
- Product name
- Ethyl2-bromonicotinate
- Purity
- >95%
- Packaging
- 1g
- Price
- $396
- Updated
- 2021/12/16
- Product number
- Y9350
- Product name
- Ethyl2-bromonicotinate
- Packaging
- 1g
- Price
- $584
- Updated
- 2021/12/16
- Product number
- 61-2951
- Product name
- Ethyl2-bromonicotinate
- Purity
- 95%-98%
- Packaging
- 0.25g
- Price
- $620
- Updated
- 2021/12/16
2-BROMONICOTINIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Synthesis Reference(s)
The Journal of Organic Chemistry, 41, p. 2066, 1976 DOI: 10.1021/jo00873a051
Synthesis
105-56-6
927-63-9
53087-78-8
Ethyl cyanoacetate (59 mL, 0.5 mol) and 1-dodecyl-3-methylimidazolium chloride (50 mL) were added to the reactor, followed by 3-dimethylaminoacrylate (62 mL, 0.5 mol) and stirred well. The reaction mixture was heated to 90 °C in an oil bath and kept at this temperature for 4 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent: petroleum ether/dichloromethane = 1:2, color developer: iodine vapor), and after confirming the complete reaction of 3-dimethylaminobenzaldehyde, the reaction mixture was cooled to room temperature. The reaction mixture was extracted three times with 1,2-dichloroethane (60 mL) and the organic phases were combined. The aqueous phase was washed with deionized water, dried under vacuum and recycled. Dry hydrogen bromide (HBr) gas was passed into the organic phase until completion of the reaction was confirmed by high performance liquid chromatography (HPLC). The pH of the reaction mixture was adjusted to 5-6 with 20% sodium carbonate solution and then the aqueous phase was extracted with 1,2-dichloroethane (20 mL x 3). The organic layers were combined, dried over molecular sieves, filtered and the solvent was evaporated under reduced pressure to recover 1,2-dichloroethane to give ethyl 2-bromonicotinate (108.4 g, light brown liquid) in 94.0% yield.
References
[1] Patent: CN105001154, 2017, B. Location in patent: Paragraph 0049; 0050; 0051; 0052
[2] Patent: CN104945317, 2018, B. Location in patent: Paragraph 0047; 0048
2-BROMONICOTINIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
2-BROMONICOTINIC ACID ETHYL ESTER Suppliers
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View Lastest Price from 2-BROMONICOTINIC ACID ETHYL ESTER manufacturers
- Product
- 2-BROMONICOTINIC ACID ETHYL ESTER 53087-78-8
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- ask
- Release date
- 2020-01-08