2-chloro-5-(trifluoromethyl)-4-iodopyridine
- Product Name
- 2-chloro-5-(trifluoromethyl)-4-iodopyridine
- CAS No.
- 505084-55-9
- Chemical Name
- 2-chloro-5-(trifluoromethyl)-4-iodopyridine
- Synonyms
- CAS:505084-55-9;505084-55-9;chloro-5-(trifluoromethyl)-4-iodopyridine;2-Chloro-4-iodo-5-(trifluoromethyl)pyridine;2-CHLORO-5-(TRIFLUOROMETHYL)-4-IODOPHRIDINE;2-chloro-5-(trifluoromethyl)-4-iodopyridine;Pyridine, 2-chloro-4-iodo-5-(trifluoromethyl)-;2-Chloro-4-iodo-5-(trifluoromethyl)pyridine >2-chloro -4-iodine -5- threefluorineMethyl pyridine;2-Chloro-4-iodo-5-(trifluoromethyl)pyridine,tech.90%
- CBNumber
- CB31094122
- Molecular Formula
- C6H2ClF3IN
- Formula Weight
- 307.44
- MOL File
- 505084-55-9.mol
2-chloro-5-(trifluoromethyl)-4-iodopyridine Property
- Melting point:
- 126.0 to 130.0 °C
- Boiling point:
- 257.6±40.0 °C(Predicted)
- Density
- 2.046±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform, Methanol
- form
- Solid
- pka
- -2.74±0.10(Predicted)
- color
- Light Tan
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C6H2ClF3IN/c7-5-1-4(11)3(2-12-5)6(8,9)10/h1-2H
- InChIKey
- XEEQBBXEZSNIQV-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(C(F)(F)F)C(I)=C1
- CAS DataBase Reference
- 505084-55-9
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C2999
- Product name
- 2-Chloro-4-iodo-5-(trifluoromethyl)pyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $45
- Updated
- 2025/07/31
- Product number
- C2999
- Product name
- 2-Chloro-4-iodo-5-(trifluoromethyl)pyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $180
- Updated
- 2025/07/31
- Product number
- C367325
- Product name
- 2-Chloro-4-iodo-5-(trifluoromethyl)pyridine
- Packaging
- 5G
- Price
- $180
- Updated
- 2021/12/16
- Product number
- C13816
- Product name
- 2-Chloro-4-iodo-5-(trifluoromethyl)pyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $5
- Updated
- 2021/12/16
- Product number
- PC9878
- Product name
- 2-Chloro-4-iodo-5-(trifluoromethyl)pyridine
- Packaging
- 1g
- Price
- $13
- Updated
- 2021/12/16
2-chloro-5-(trifluoromethyl)-4-iodopyridine Chemical Properties,Usage,Production
Uses
2-Chloro-4-iodo-5-(trifluoromethyl)pyridine is used in preparation of pyridine-2,4-diamine derivatives as FAK inhibitors for the treatment of arthritis, inflammatory and immune disorders.
Uses
2-chloro-5-(trifluoromethyl)-4-iodopyridine is used in preparation of pyridine-2,4-diamine derivatives as FAK inhibitors for the treatment of arthritis, inflammatory and immune disorders.
Synthesis
52334-81-3
505084-55-9
The general procedure for the synthesis of 2-chloro-5-trifluoromethyl-4-iodopyridine from 2-chloro-5-trifluoromethylpyridine was as follows: diisopropylamine (3.3330 g, 32.94 mmol) and anhydrous THF (33 mL) were added to 100 mL of a cigar shaped flask and protected under Ar atmosphere. The reaction system was cooled to -78 °C, n-butyllithium (1.58 M hexane solution, 20.8 mL, 32.86 mmol) was slowly added dropwise and stirred at the same temperature for 10 min. Subsequently, 2-chloro-5-trifluoromethylpyridine (5.4616 g, 30.08 mmol) dissolved in anhydrous THF (30 mL) was added slowly dropwise at -78 °C and stirring was continued at the same temperature for 1 hour. Next, iodine (9.2188 g, 36.32 mmol) dissolved in anhydrous THF (30 mL) was added dropwise at -78 °C and stirred at the same temperature for 30 min before slowly warming to 0 °C. The reaction was quenched by the addition of 1 M aqueous sodium thiosulfate (50 mL) at 0 °C. The reaction was extracted three times with ethyl acetate, and the organic phases were combined and dried over anhydrous sodium sulfate. After removal of the solvent by distillation under reduced pressure, the resulting residue was purified by silica gel column chromatography (BW-200,80 g, eluent 30% benzene/hexane) to afford the target product 2-chloro-5-trifluoromethyl-4-iodopyridine (4.3977 g, 14.30 mmol, 48% yield). In addition, a white powdery product was obtained by recrystallization from EtOH.
References
[1] European Journal of Organic Chemistry, 2003, # 8, p. 1559 - 1568
[2] Patent: JP2016/700, 2016, A. Location in patent: Paragraph 0032
[3] Patent: WO2008/115369, 2008, A2. Location in patent: Page/Page column 50-51
2-chloro-5-(trifluoromethyl)-4-iodopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-chloro-5-(trifluoromethyl)-4-iodopyridine Suppliers
- Tel
- 0311-0311-67790228 15531158659
- Fax
- 66571013
- 1257738041@qq.com
- Country
- China
- ProdList
- 297
- Advantage
- 62
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 0519-89803565 13776850645
- Fax
- 0519-89803575
- info4@huanlingchem.com
- Country
- China
- ProdList
- 891
- Advantage
- 68
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 17702719238 18971495150;
- sales@sun-shinechem.com
- Country
- China
- ProdList
- 1077
- Advantage
- 64
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9883
- Advantage
- 59
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7811
- Advantage
- 57
- Tel
- 021-20958197 20965099
- Fax
- 021-20960837
- sales@skychemical.com
- Country
- China
- ProdList
- 1183
- Advantage
- 57
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- 021-56491756 13512199871
- Fax
- 021-5649-1756
- 2819742715@qq.com
- Country
- China
- ProdList
- 4000
- Advantage
- 55
- Tel
- 022-58013646 13011382049
- Fax
- 022-23854368
- sales@jinyudachem.com
- Country
- China
- ProdList
- 1930
- Advantage
- 55
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9546
- Advantage
- 55
- Tel
- 025-58649566 15005191108
- Fax
- 025-58649599
- sales@njboyuanchem.com
- Country
- China
- ProdList
- 113
- Advantage
- 60
- Tel
- 13816107857
- Fax
- qq: 276312098
- sales@fortunechem-sh.com
- Country
- China
- ProdList
- 984
- Advantage
- 58
- Tel
- 86-0755-86635001
- Fax
- 86-0755-22642228
- cantotech@126.com
- Country
- China
- ProdList
- 4566
- Advantage
- 55
- Tel
- 0319-5801333-8008 15630992918
- sales@summedchem.com
- Country
- China
- ProdList
- 965
- Advantage
- 58
- Tel
- +86-18921203887
- Fax
- +86-0510-86319635 ; QQ:1622023101
- sales@canalpharm.net
- Country
- China
- ProdList
- 288
- Advantage
- 58
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- 422131432@qq.com
- Country
- China
- ProdList
- 9979
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9476
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15178
- Advantage
- 58
- Tel
- 86-574-27787657
- Fax
- 86-574-27912196
- info@dearchem.com
- Country
- China
- ProdList
- 4613
- Advantage
- 58
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10263
- Advantage
- 55
- Tel
- 15121041756
- xingui2022@126.com
- Country
- China
- ProdList
- 9979
- Advantage
- 58
- Tel
- 86-021-61559134 15921386130
- Fax
- 021-55068248
- 3423497944@qq.com
- Country
- China
- ProdList
- 8144
- Advantage
- 55
- Tel
- 025-66028182 18626450290
- yftan@aikonchem.com
- Country
- China
- ProdList
- 16679
- Advantage
- 50
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- 86(21)68097365
- Fax
- 86(21)33321566
- sales@anpharma.net
- Country
- China
- ProdList
- 4891
- Advantage
- 55
- Tel
- 022-60131465 18920720807
- Fax
- 022-58558581
- zishan_1986@163.com
- Country
- China
- ProdList
- 743
- Advantage
- 58
- Tel
- 0570-8789886 18892685668
- Fax
- 0570-8789985
- info@rundongchemical.com
- Country
- China
- ProdList
- 4053
- Advantage
- 60
- Tel
- 0512-63009836 18994340901
- Fax
- 0512-63006936
- helen@struchem.com
- Country
- China
- ProdList
- 3981
- Advantage
- 60
- Tel
- 13817873692
- Fax
- 021-31329586
- mkt@boynerspharm.com
- Country
- China
- ProdList
- 1707
- Advantage
- 55
- Tel
- 86-(0)21-31261262 373522135
- Fax
- 86-(0)21-33250524
- sales@novochemy.com
- Country
- China
- ProdList
- 6498
- Advantage
- 58
- Tel
- 028-88469284 18000562381
- rzbtsj@163.com
- Country
- China
- ProdList
- 9951
- Advantage
- 56
- Tel
- 021-61556450 15800904410
- Fax
- 021-61556450
- Country
- China
- ProdList
- 2832
- Advantage
- 58
- Tel
- 13764913901
- Fax
- -
- info@angtibio.com
- Country
- China
- ProdList
- 4985
- Advantage
- 55
- Tel
- 18620099427
- Fax
- +86-20-62619665
- amy@howeipharm.com
- Country
- China
- ProdList
- 6687
- Advantage
- 55
View Lastest Price from 2-chloro-5-(trifluoromethyl)-4-iodopyridine manufacturers
- Product
- 2-chloro-5-(trifluoromethyl)-4-iodopyridine 505084-55-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14
- Product
- 2-chloro-5-(trifluoromethyl)-4-iodopyridine 505084-55-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-01
- Product
- 2-chloro-5-(trifluoromethyl)-4-iodopyridine 505084-55-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-01