2-chloro-5-(trifluoromethyl)-4-iodopyridine
- Product Name
- 2-chloro-5-(trifluoromethyl)-4-iodopyridine
- CAS No.
- 505084-55-9
- Chemical Name
- 2-chloro-5-(trifluoromethyl)-4-iodopyridine
- Synonyms
- CAS:505084-55-9;505084-55-9;chloro-5-(trifluoromethyl)-4-iodopyridine;2-Chloro-4-iodo-5-(trifluoromethyl)pyridine;2-CHLORO-5-(TRIFLUOROMETHYL)-4-IODOPHRIDINE;2-chloro-5-(trifluoromethyl)-4-iodopyridine;Pyridine, 2-chloro-4-iodo-5-(trifluoromethyl)-;2-Chloro-4-iodo-5-(trifluoromethyl)pyridine >2-chloro -4-iodine -5- threefluorineMethyl pyridine;2-Chloro-4-iodo-5-(trifluoromethyl)pyridine,tech.90%
- CBNumber
- CB31094122
- Molecular Formula
- C6H2ClF3IN
- Formula Weight
- 307.44
- MOL File
- 505084-55-9.mol
2-chloro-5-(trifluoromethyl)-4-iodopyridine Property
- Melting point:
- 126.0 to 130.0 °C
- Boiling point:
- 257.6±40.0 °C(Predicted)
- Density
- 2.046±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform, Methanol
- form
- Solid
- pka
- -2.74±0.10(Predicted)
- color
- Light Tan
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C6H2ClF3IN/c7-5-1-4(11)3(2-12-5)6(8,9)10/h1-2H
- InChIKey
- XEEQBBXEZSNIQV-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(C(F)(F)F)C(I)=C1
- CAS DataBase Reference
- 505084-55-9
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C2999
- Product name
- 2-Chloro-4-iodo-5-(trifluoromethyl)pyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $45
- Updated
- 2025/07/31
- Product number
- C2999
- Product name
- 2-Chloro-4-iodo-5-(trifluoromethyl)pyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $180
- Updated
- 2025/07/31
- Product number
- C367325
- Product name
- 2-Chloro-4-iodo-5-(trifluoromethyl)pyridine
- Packaging
- 5G
- Price
- $180
- Updated
- 2021/12/16
- Product number
- FC30782
- Product name
- 2-Chloro-4-iodo-5-(trifluoromethyl)-pyridine
- Packaging
- 25g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- 50285
- Product name
- 2-Chloro-4-iodo-5-(trifluoromethyl)pyridine
- Packaging
- 1g
- Price
- $620
- Updated
- 2021/12/16
2-chloro-5-(trifluoromethyl)-4-iodopyridine Chemical Properties,Usage,Production
Uses
2-Chloro-4-iodo-5-(trifluoromethyl)pyridine is used in preparation of pyridine-2,4-diamine derivatives as FAK inhibitors for the treatment of arthritis, inflammatory and immune disorders.
Uses
2-chloro-5-(trifluoromethyl)-4-iodopyridine is used in preparation of pyridine-2,4-diamine derivatives as FAK inhibitors for the treatment of arthritis, inflammatory and immune disorders.
Synthesis
52334-81-3
505084-55-9
The general procedure for the synthesis of 2-chloro-5-trifluoromethyl-4-iodopyridine from 2-chloro-5-trifluoromethylpyridine was as follows: diisopropylamine (3.3330 g, 32.94 mmol) and anhydrous THF (33 mL) were added to 100 mL of a cigar shaped flask and protected under Ar atmosphere. The reaction system was cooled to -78 °C, n-butyllithium (1.58 M hexane solution, 20.8 mL, 32.86 mmol) was slowly added dropwise and stirred at the same temperature for 10 min. Subsequently, 2-chloro-5-trifluoromethylpyridine (5.4616 g, 30.08 mmol) dissolved in anhydrous THF (30 mL) was added slowly dropwise at -78 °C and stirring was continued at the same temperature for 1 hour. Next, iodine (9.2188 g, 36.32 mmol) dissolved in anhydrous THF (30 mL) was added dropwise at -78 °C and stirred at the same temperature for 30 min before slowly warming to 0 °C. The reaction was quenched by the addition of 1 M aqueous sodium thiosulfate (50 mL) at 0 °C. The reaction was extracted three times with ethyl acetate, and the organic phases were combined and dried over anhydrous sodium sulfate. After removal of the solvent by distillation under reduced pressure, the resulting residue was purified by silica gel column chromatography (BW-200,80 g, eluent 30% benzene/hexane) to afford the target product 2-chloro-5-trifluoromethyl-4-iodopyridine (4.3977 g, 14.30 mmol, 48% yield). In addition, a white powdery product was obtained by recrystallization from EtOH.
References
[1] European Journal of Organic Chemistry, 2003, # 8, p. 1559 - 1568
[2] Patent: JP2016/700, 2016, A. Location in patent: Paragraph 0032
[3] Patent: WO2008/115369, 2008, A2. Location in patent: Page/Page column 50-51
2-chloro-5-(trifluoromethyl)-4-iodopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-chloro-5-(trifluoromethyl)-4-iodopyridine Suppliers
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View Lastest Price from 2-chloro-5-(trifluoromethyl)-4-iodopyridine manufacturers
- Product
- 2-chloro-5-(trifluoromethyl)-4-iodopyridine 505084-55-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14
- Product
- 2-chloro-5-(trifluoromethyl)-4-iodopyridine 505084-55-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-01
- Product
- 2-chloro-5-(trifluoromethyl)-4-iodopyridine 505084-55-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-01