3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine

Product Name: 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine
CAS No.: 76041-73-1
Chemical Name: 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine
Synonyms: 3-Bromo-2-hydroxy-5-(trifL;3-Bromo-5-(trifluoromethyl)pyridin-2-ol;3-bromo-5-(trifluoromethyl)pyridine-2-ol;3-Bromo-5-(Trifluoromethyl)pyridin-2-ylol;3-bromo-5-(trifluoromethyl)-1h-pyridin-2-one;3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine;2(1H)-Pyridinone,3-bromo-5-(trifluoromethyl)-;2-Hydroxy-3-bromo-5-(trifluoromethyl)pyridine;3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine98%;3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine 98%
CBNumber: CB31107291
Molecular Formula: C6H3BrF3NO
Formula Weight: 241.99
MOL File: 76041-73-1.mol

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3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine Property

Boiling point:: 252.7±40.0 °C(Predicted)
Density: 1.876±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 8.06±0.10(Predicted)
form: Crystalline Powder
color: White to yellow

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Safety

Hazard Codes: Xi,T
Risk Statements: 25
Safety Statements: 45
HazardClass: IRRITANT
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B696278
Product name: 3-Bromo-2-hydroxy-5-trifluoromethylpyridine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: PC7971
Product name: 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine
Purity: 98%
Packaging: 1g
Price: $16
Updated: 2021/12/16

Matrix Scientific

Product number: 026739
Product name: 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine
Purity: 98%
Packaging: 5g
Price: $25
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H01-B-X0
Product name: 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine
Purity: 98%
Packaging: 1g
Price: $26
Updated: 2021/12/16

Apolloscientific

Product number: PC7971
Product name: 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine
Purity: 98%
Packaging: 5g
Price: $29
Updated: 2021/12/16

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3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine Chemical Properties,Usage,Production

Synthesis

33252-63-0

76041-73-1

General procedure for the synthesis of 2-hydroxy-3-bromo-5-trifluoromethylpyridine from 2-hydroxy-5-trifluoromethylpyridine: to a solution of 5-(trifluoromethyl)pyridin-2-ol (10.52 g, 62 mmol) and sodium acetate (5.29 g, 64 mmol) in glacial acetic acid (38 mL) was added slowly with bromine (3.36 mL, 65 mmol) and the reaction was at room temperature. The reaction was carried out at room temperature. After observing the gradual transformation of the white turbid solution into a clarified brown solution, the reaction mixture was heated and refluxed at 80 °C for 2.5 h. After the reaction was completed, the mixture was cooled and refluxed for 2.5 h. The reaction was carried out at room temperature. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was subsequently removed by evaporation under reduced pressure. The residue was neutralized with saturated sodium bicarbonate solution to pH=8. The neutralized aqueous phase was extracted three times with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product 15.1 g (99.8% yield) as a white solid. The purity of the product was confirmed by LC-MS with a calculated value of [M+H]+ of C6H3BrF3NO of 241.9 and a measured value of 241.9/243.9.

References

[1] Patent: US2005/267146, 2005, A1. Location in patent: Page/Page column 22-23
[2] Patent: WO2004/82682, 2004, A1. Location in patent: Page 47-48
[3] Patent: WO2004/94371, 2004, A2. Location in patent: Page 59
[4] Patent: US2008/81803, 2008, A1. Location in patent: Page/Page column 25
[5] Patent: US2007/117797, 2007, A1. Location in patent: Page/Page column 23

3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine Suppliers

China 135 India 3 United Kingdom 3 United States 15 Global 156

Accela ChemBio Inc.

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View Lastest Price from 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine 76041-73-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-30

Henan Fengda Chemical Co., Ltd

Product: 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine 76041-73-1
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Dideu Industries Group Limited

Product: 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine 76041-73-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-26

76041-73-1, 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridineRelated Search:

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76041-73-1

C6H3BrF3NO

blocks

Bromides

Pyridines