5-Bromo-2-methoxyacetophenone
- Product Name
- 5-Bromo-2-methoxyacetophenone
- CAS No.
- 16740-73-1
- Chemical Name
- 5-Bromo-2-methoxyacetophenone
- Synonyms
- 5-BROMO-2-METHOXYACETOPHENONE;5'-Bromo-2'-methoxyacetophenone;Ethanone, 1-(5-bromo-2-methoxyphenyl)-;1-(5-Bromo-2-methoxyphenyl)ethan-1-one;JR-8526, 1-(5-Bromo-2-methoxyphenyl)ethanone, 97%
- CBNumber
- CB31116141
- Molecular Formula
- C9H9BrO2
- Formula Weight
- 229.07
- MOL File
- 16740-73-1.mol
5-Bromo-2-methoxyacetophenone Property
- Melting point:
- 39 °C
- Boiling point:
- 165 °C
- Density
- 1.421±0.06 g/cm3(Predicted)
- storage temp.
- Store at room temperature
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2914500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
N-Bromosuccinimide Price
- Product number
- B415903
- Product name
- 1-(5-Bromo-2-methoxyphenyl)ethanone
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR400108
- Product name
- 5'-Bromo-2'-methoxyacetophenone
- Packaging
- 1g
- Price
- $63
- Updated
- 2021/12/16
- Product number
- AK-40233
- Product name
- 1-(5-Bromo-2-methoxyphenyl)ethanone
- Purity
- 98%
- Packaging
- 5g
- Price
- $68
- Updated
- 2021/12/16
- Product number
- 2617-9-22
- Product name
- 5'-Bromo-2'-methoxyacetophenone
- Packaging
- 1g
- Price
- $69
- Updated
- 2021/12/16
- Product number
- FB54241
- Product name
- 1-(5-Bromo-2-methoxyphenyl)ethanone
- Packaging
- 10g
- Price
- $130.1
- Updated
- 2021/12/16
5-Bromo-2-methoxyacetophenone Chemical Properties,Usage,Production
Preparation
Preparation by reaction of methyl iodide with 5-bromo-2-hydroxyacetophenone in the presence of potassium carbonate in refluxing acetone for 3 h (86%).
Synthesis
579-74-8
16740-73-1
General procedure for the synthesis of 1-(5-bromo-2-methoxyphenyl)-acetophenone from 2'-methoxyacetophenone: N-bromosuccinimide (NBS, 1.5 eq., 0.3 mmol), catalyst (10 mol%, 0.02 mmol), and acetonitrile (CH3CN, 1.0 mL) were added to the reaction tube, followed by 2'-methoxyacetophenone (0.2 mmol). The reaction mixture was stirred for 12 h at room temperature protected from light. After completion of the reaction, the reaction was quenched with saturated sodium thiosulfate (Na2S2O3) aqueous solution (2 mL). The reaction mixture was extracted with ethyl acetate (3.5 mL). The organic phases were combined, washed with brine (10 mL), dried over anhydrous sodium sulfate (Na2SO4), and filtered through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure and the residue was purified by rapid chromatography on a silica gel column using petroleum ether/dichloromethane (5:1) as eluent to afford the target product 1-(5-bromo-2-methoxyphenyl)-ethanone.
References
[1] Tetrahedron, 2017, vol. 73, # 50, p. 7105 - 7114
[2] Tetrahedron Letters, 2006, vol. 47, # 27, p. 4707 - 4710
[3] Patent: US9138427, 2015, B2. Location in patent: Page/Page column 312-313
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987, p. 1423 - 1428
[5] Synthesis (Germany), 2013, vol. 45, # 11, p. 1497 - 1504
5-Bromo-2-methoxyacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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