Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate
- Product Name
- Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate
- CAS No.
- 885270-84-8
- Chemical Name
- Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate
- Synonyms
- 2,6-Diazaspiro[3.4]octane, N2-BOC protected;tert-Butyl 2,6-diazaspiro...;2-Boc-2,6-diaza-spiro[3.4]octane;tert-Butyl-2,6-diazaspiro[3.4]octan-2-carboxylat;tert-Butyl 2,6-diazaspiro[3.4]octan-2-carboxylate;tert-Butyl 2,7-diazaspiro[3.4]octane-2-carboxylate;2,6-Diaza-spiro[3.4]octane-2-carboxylic acid tert-butyl;1,1-Dimethylethyl 2,6-diazaspiro[3.4]octane-2-carboxylate;2,6-Diazaspiro[3.4]octan-2-carboxylic acid tert-butyl ester;Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate.hemioxalate
- CBNumber
- CB31116242
- Molecular Formula
- C11H20N2O2
- Formula Weight
- 212.29
- MOL File
- 885270-84-8.mol
Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate Property
- Boiling point:
- 301.3±35.0 °C(Predicted)
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 10.65±0.20(Predicted)
- form
- solid
- color
- Off-white
- InChI
- InChI=1S/C11H20N2O2/c1-10(2,3)15-9(14)13-7-11(8-13)4-5-12-6-11/h12H,4-8H2,1-3H3
- InChIKey
- UJIOQJJFPYXAEM-UHFFFAOYSA-N
- SMILES
- C1C2(CCNC2)CN1C(OC(C)(C)C)=O
Safety
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D6472
- Product name
- tert-Butyl 2,6-Diazaspiro[3.4]octane-2-carboxylate
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $112
- Updated
- 2026/03/19
- Product number
- D6472
- Product name
- tert-Butyl 2,6-Diazaspiro[3.4]octane-2-carboxylate
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $335
- Updated
- 2026/03/19
- Product number
- B694015
- Product name
- tert-Butyl2,6-diazaspiro[3.4]octane-2-carboxylate
- Packaging
- 250mg
- Price
- $580
- Updated
- 2021/12/16
- Product number
- Y4495
- Product name
- 2,6-Diazaspiro[3.4]octane-2-carboxylicacidtert-butylester
- Packaging
- 100mg
- Price
- $104
- Updated
- 2021/12/16
- Product number
- 4H56-1-113
- Product name
- tert-Butyl 2,6-diazaspiro[3.4]octane-2-carboxylate
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate Chemical Properties,Usage,Production
Uses
tert-Butyl 2,6-diazaspiro[3.4]octane-2-carboxylate can be used to synthesize ketohexokinase (KHK) inhibitors that have potential medical uses for treating diabetes and obesity.tert-Butyl 2,6-diazaspiro[3.4]octane-2-carboxylate is also a useful reagent for the synthesis of dihydroisoindolecarboxamide derivatives asNicotinamide Phosphoribosyltransferase (NAMPT) andRho-associated protein kinase (ROCK)inhibitors.
Pharmaceutical Applications
2,6-diazaspiro[3.4]octane is the main structure of Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate. The fully saturated, high-Fsp3 2,6-diazaspiro[3.4]octane core is an emerging privileged structure, taking into account its recent frequent appearance in compounds possessing diverse biological activities. Notable recently reported examples include a hepatitis B capsid protein inhibitor, a menin-MLL1 interaction inhibitor for the treatment of cancer, a MAP and PI3K signaling modulator, a selective dopamine D3 receptor antagonist, and VDAC1 inhibitors for the treatment of diabetes[1].
References
[1] Lukin, A.; Komarova, K.; Vinogradova, L.; Dogonadze, M.; Vinogradova, T.; Yablonsky, P.; Kazantsev, A.; Krasavin, M. Periphery Exploration around 2,6-Diazaspiro[3.4]octane Core Identifies a Potent Nitrofuran Antitubercular Lead. Molecules 2023, 28, 2529. DOI:10.3390/molecules28062529
Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate Preparation Products And Raw materials
Raw materials
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View Lastest Price from Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate manufacturers
- Product
- Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate 885270-84-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-11-11
- Product
- tert-Butyl-2,6-diazaspiro[3.4]octan-2-carboxylat 885270-84-8
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-08-05
- Product
- Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate 885270-84-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-31