Droprenilamine Property

Boiling point:

466.0±34.0 °C(Predicted)

Density 

0.975±0.06 g/cm3(Predicted)

pka

10.52±0.29(Predicted)

Hazard and Precautionary Statements (GHS)

Droprenilamine Chemical Properties,Usage,Production

Originator

Valcor,Maggioni,Italy,1979

Uses

Vasodilator (coronary).

Definition

ChEBI: Droprenilamine is a diarylmethane.

Manufacturing Process

The flask of a Parr hydrogenation apparatus was charged with 10.5 g of 3,3-diphenylpropylamine, 7.7 g of cyclohexylacetone, 50 ml methanol and 150 mg of platinum dioxide. Hydrogen at a pressure of 3 atmospheres was introduced and the mixture stirred. Upon absorption of the theoretical amount of hydrogen, stirring is discontinued, the catalyst is filtered off and the solution is evaporated to dryness. The residue is taken up with ether and the hydrochloride is precipitated with HCl in alcoholic solution. The product, as collected on a filter and washed with ether, is recrystallized from isopropanol. Yield: 17 g (92.5% of theory). MP: 175°C to 177°C.

brand name

Valcor (Maggioni Farmaceutici S.p.A., Italy).

Therapeutic Function

Coronary vasodilator