2,4-Dichloro-6-fluoroquinoline
Uses- Product Name
- 2,4-Dichloro-6-fluoroquinoline
- CAS No.
- 406204-74-8
- Chemical Name
- 2,4-Dichloro-6-fluoroquinoline
- Synonyms
- CAS:406204-74-8;2,4-DICHLORO-6-FLUORO-QUINOLINE;Quinoline, 2,4-dichloro-6-fluoro-
- CBNumber
- CB31118594
- Molecular Formula
- C9H4Cl2FN
- Formula Weight
- 216.04
- MOL File
- 406204-74-8.mol
2,4-Dichloro-6-fluoroquinoline Property
- Melting point:
- 92 °C
- Boiling point:
- 290.1±35.0 °C(Predicted)
- Density
- 1.491±0.06 g/cm3(Predicted)
- storage temp.
- Store at room temperature
- form
- crystalline powder
- pka
- -1.80±0.50(Predicted)
- color
- White/ off-white
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D487665
- Product name
- 2,4-Dichloro-6-fluoroquinoline
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- PC449020
- Product name
- 2,4-Dichloro-6-fluoroquinoline
- Packaging
- 1g
- Price
- $76
- Updated
- 2021/12/16
- Product number
- FD42192
- Product name
- 2,4-Dichloro-6-fluoroquinoline
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 3H32-7-1E
- Product name
- 2,4-Dichloro-6-fluoroquinoline
- Packaging
- 1g
- Price
- $122
- Updated
- 2021/12/16
- Product number
- FD42192
- Product name
- 2,4-Dichloro-6-fluoroquinoline
- Packaging
- 500mg
- Price
- $125
- Updated
- 2021/12/16
2,4-Dichloro-6-fluoroquinoline Chemical Properties,Usage,Production
Uses
2,4-Dichloro-6-fluoroquinoline, as a synthetic intermediate for quinoline compounds, is mainly used in laboratory organic synthesis and chemical production processes.
Synthesis
141-82-2
371-40-4
406204-74-8
a) Synthesis of 2,4-dichloro-6-fluoroquinoline: 4-fluoroaniline (8.5 g, 76.5 mmol) was mixed with malonic acid (8.0 g, 76.9 mmol), trichlorophosphorus (160 g, 1.04 mol) was added, slowly heated to 100 °C and the reaction was maintained at this temperature for 18 hours. After completion of the reaction, the mixture was cooled to room temperature and poured into ice water (1.0 L). The brown slurry obtained was filtered and purified by fast column chromatography (silica gel 350 g, 6 x 24 cm column, dichloromethane elution) to obtain 3.37 g of 2,4-dichloro-6-fluoroquinoline as an off-white solid in 20% yield.
References
[1] Research on Chemical Intermediates, 2014, vol. 40, # 5, p. 1851 - 1866
[2] Medicinal Chemistry, 2015, vol. 11, # 8, p. 789 - 797
[3] Patent: WO2005/66132, 2005, A1. Location in patent: Page/Page column 39
2,4-Dichloro-6-fluoroquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Dichloro-6-fluoroquinoline manufacturers
- Product
- 2,4-Dichloro-6-fluoroquinoline 406204-74-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2018-08-06