ChemicalBook > CAS DataBase List > 2-CHLORO-6-FLUOROQUINOLINE

2-CHLORO-6-FLUOROQUINOLINE

Product Name
2-CHLORO-6-FLUOROQUINOLINE
CAS No.
77119-53-0
Chemical Name
2-CHLORO-6-FLUOROQUINOLINE
Synonyms
2-CHLORO-6-FLUOROQUINOLINE;6-FLUORO-2-CHLORO-QUINOLINE;Quinoline, 2-chloro-6-fluoro-;2-chloro-6-fluoro-quinoline - [C87398]
CBNumber
CB8130488
Molecular Formula
C9H5ClFN
Formula Weight
181.59
MOL File
77119-53-0.mol
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2-CHLORO-6-FLUOROQUINOLINE Property

storage temp. 
Sealed in dry,2-8°C
form 
solid
color 
BROWN
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Safety

HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C585230
Product name
2-Chloro-6-fluoroquinoline
Packaging
1g
Price
$495
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0122627
Product name
2-CHLORO-6-FLUOROQUINOLINE
Purity
95.00%
Packaging
0.25G
Price
$616
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0122627
Product name
2-CHLORO-6-FLUOROQUINOLINE
Purity
95.00%
Packaging
1G
Price
$785.4
Updated
2021/12/16
Apolloscientific
Product number
PC404621
Product name
2-Chloro-6-fluoroquinoline
Purity
98%
Packaging
250mg
Price
$99
Updated
2021/12/16
AK Scientific
Product number
V7699
Product name
2-Chloro-6-fluoroquinoline
Packaging
250mg
Price
$157
Updated
2021/12/16
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2-CHLORO-6-FLUOROQUINOLINE Chemical Properties,Usage,Production

Synthesis

22614-75-1

77119-53-0

6-Fluoro-1,2-dihydroquinolin-2-one (7.8 g, 47.8 mmol) was used as a raw material, which was suspended in phosphoryl chloride (72.2 g, 470.9 mmol) and the reaction was stirred at 100 °C in an oil bath for 4 hours. Upon completion of the reaction, excess phosphorus trichloride was removed by vacuum concentration, followed by addition of ice water (200 ml) to the reaction mixture to quench the reaction. The resulting precipitate was washed with water (2 x 80 ml) and dried to afford 2-chloro-6-fluoroquinoline as an off-white solid (6.8 g, 78% yield). The product was confirmed by mass spectrometry (ES, m/z): [M + H]+ 182; 1H NMR (300 MHz, DMSO) data were as follows: δ 8.43 (d, J=8.4 Hz, 1H), 8.01 (dd, J=5.4 Hz, 9.3 Hz, 1H), 7.87 (dd, J=3.0 Hz, 9.3 Hz, 1H), 7.72-7.78 (m, 1H), 7.45 (d, J=8.4Hz, 1H).

References

[1] Patent: US2014/142114, 2014, A1. Location in patent: Paragraph 0448, 0449
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 22, p. 5405 - 5417

2-CHLORO-6-FLUOROQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-6-FLUOROQUINOLINE Suppliers

China 46 India 1 United Kingdom 1 United States 8 Global 56
Energy Chemical
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021-021-58432009 400-005-6266
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021-58436166
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sales8178@energy-chemical.com
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66113011 17798518460
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(1)02557626880
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cfzhang@aikonchem.com
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China
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9ding chemical ( Shanghai) Limited
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4009209199
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86-021-52271987
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China
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SynAsst Chemical.
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China
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Shanghai Worldyang Chemical Co.,Ltd.
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+86-21-56795266
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Suzhou Laing Biological Technology Co., LTD
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0512-62968256 18550502935
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export@laingbiotec.com
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Nantong Bosu Pharmaceutical Technology Co., Ltd.
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Mashilabs (Shanghai) Co.,Ltd.
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19916721580
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ShangHai AmK Pharmaceutical Technology Co., Ltd.
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微信 17321281695 18019252918
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17321281695
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sale@amkchem.com
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China
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Nanjing Chalf-Pharm Technology Co., Ltd.
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025-57018978 18251899859
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025-57018008
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sales@chalf-pharm.com
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China
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View Lastest Price from 2-CHLORO-6-FLUOROQUINOLINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2-Chloro-6-fluoroquinoline 77119-53-0
Price
US $1.10-9.90/KG
Min. Order
1KG
Purity
99% min
Supply Ability
100kg
Release date
2025-08-18

77119-53-0, 2-CHLORO-6-FLUOROQUINOLINERelated Search:

ETHYL 4-CHLORO-6-FLUOROQUINOLINE-3-CARBOXYLATE 2-Chloro-6,7-difluoro-3-quinolinecarboxaldehyde 2,4-Dichloro-6-fluoroquinoline 4-CHLORO-8-FLUOROQUINOLINE 7-Chloro-8-fluoroquinoline 4-CHLORO-6-FLUOROQUINOLINE 2-CHLORO-4-FLUOROQUINOLINE 2-CHLORO-6-FLUOROQUINOLINE-3-CARBONITRILE 2-CHLORO-6-FLUORO-3-METHYLQUINOLINE 2-CHLORO-6-FLUORO-4-METHYLQUINOLINE 2-CHLORO-6-FLUOROQUINOLINE-3-METHANOL 2-CHLORO-7-FLUOROQUINOLINE-3-METHANOL 4-CHLORO-5-FLUOROQUINOLINE 2-CHLORO-6-FLUOROQUINOLINE-3-CARBOXALDEHYDE 2-CHLORO-6-FLUOROQUINOLINE 4-CHLORO-7-FLUOROQUINOLINE 2-CHLORO-7-FLUOROQUINOLINE-3-CARBONITRILE 8-chloro-5-fluoroquinoline

  • 2-CHLORO-6-FLUOROQUINOLINE
  • 6-FLUORO-2-CHLORO-QUINOLINE
  • Quinoline, 2-chloro-6-fluoro-
  • 2-chloro-6-fluoro-quinoline - [C87398]
  • 77119-53-0