4-Chloro-6-fluoroquinoline
Application- Product Name
- 4-Chloro-6-fluoroquinoline
- CAS No.
- 391-77-5
- Chemical Name
- 4-Chloro-6-fluoroquinoline
- Synonyms
- EOS-62017;BUTTPARK 20\09-07;4-CHLORO-6-FLUOROQUINOLINE;Quinoline, 4-chloro-6-fluoro-;4-Chloro-6-fluoroquinoline >4-CHLORO-6-FLUOROQUINOLINE(WX900022);4-
Chloro- 6- fluoroquinoline;4-Chloro-6-fluoroquinoline ISO 9001：2015 REACH - CBNumber
- CB4311449
- Molecular Formula
- C9H5ClFN
- Formula Weight
- 181.59
- MOL File
- 391-77-5.mol
4-Chloro-6-fluoroquinoline Property
- Melting point:
- 75.0 to 79.0 °C
- Boiling point:
- 259.9±20.0 °C(Predicted)
- Density
- 1.366±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 2.90±0.16(Predicted)
- form
- powder to crystal
- color
- White to Light yellow
- InChI
- InChI=1S/C9H5ClFN/c10-8-3-4-12-9-2-1-6(11)5-7(8)9/h1-5H
- InChIKey
- CKTQPWIDUQGUGG-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(F)=CC=2)C(Cl)=CC=1
- CAS DataBase Reference
- 391-77-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-41-37/38
- Safety Statements
- 26-39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BBO000711
- Product name
- 4-Chloro-6-fluoroquinoline
- Packaging
- 1G
- Price
- $99.7
- Updated
- 2023/06/20
- Product number
- 758485
- Product name
- 4-Chloro-6-fluoroquinoline
- Purity
- 97%
- Packaging
- 1g
- Price
- $81.8
- Updated
- 2023/06/20
- Product number
- C2989
- Product name
- 4-Chloro-6-fluoroquinoline
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $127
- Updated
- 2025/07/31
- Product number
- C2989
- Product name
- 4-Chloro-6-fluoroquinoline
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $437
- Updated
- 2025/07/31
- Product number
- C989153
- Product name
- 4-Chloro-6-fluoroquinoline
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
4-Chloro-6-fluoroquinoline Chemical Properties,Usage,Production
Application
4-Chloro-6-fluoroquinoline is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in laboratory research and development processes as well as in chemical and pharmaceutical synthesis.
Synthesis
38470-26-7
391-77-5
General procedure for the synthesis of 4-chloro-6-fluoroquinoline from 6-fluoro-2,3-dihydroquinolin-4(1H)-one: 412.55 mL of phosphoryl chloride, 11.5 g of iodine, and 165.0 g of manganese dioxide were added to a four-necked flask fitted with a stirrer and heated under stirring to 50 °C. Subsequently, 660 mL of a dichloroethane solution containing 165.02 g of 6-fluoro-2,3-dihydroquinolin-4(1H)-one was slowly added dropwise. After completion of the dropwise addition, the reaction mixture was refluxed for 2 hours. After completion of the reaction, the dichloroethane solvent was removed by distillation under reduced pressure. The residue was neutralized to pH 5-6 with cold aqueous sodium bicarbonate and filtered. The filter cake was washed with water to neutral and finally dried under vacuum to give 154.22 g of light gray solid 4-chloro-6-fluoroquinoline in 85.0% yield.
References
[1] Patent: CN106565602, 2017, A. Location in patent: Paragraph 0008; 0024; 0025; 0026; 0027
4-Chloro-6-fluoroquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloro-6-fluoroquinoline manufacturers
- Product
- 4-Chloro-6-fluoroquinoline 391-77-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- 4-Chloro-6-fluoroquinoline 391-77-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-14