ChemicalBook > CAS DataBase List > 4-Chloro-6-fluoroquinoline

4-Chloro-6-fluoroquinoline

Application

Product Name: 4-Chloro-6-fluoroquinoline
CAS No.: 391-77-5
Chemical Name: 4-Chloro-6-fluoroquinoline
Synonyms: EOS-62017;BUTTPARK 20\09-07;4-CHLORO-6-FLUOROQUINOLINE;Quinoline, 4-chloro-6-fluoro-;4-Chloro-6-fluoroquinoline >4-CHLORO-6-FLUOROQUINOLINE(WX900022);4-Chloro-6-fluoroquinoline;4-Chloro-6-fluoroquinoline ISO 9001：2015 REACH
CBNumber: CB4311449
Molecular Formula: C9H5ClFN
Formula Weight: 181.59
MOL File: 391-77-5.mol

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4-Chloro-6-fluoroquinoline Property

Melting point:: 75.0 to 79.0 °C
Boiling point:: 259.9±20.0 °C(Predicted)
Density: 1.366±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 2.90±0.16(Predicted)
form: powder to crystal
color: White to Light yellow
InChI: InChI=1S/C9H5ClFN/c10-8-3-4-12-9-2-1-6(11)5-7(8)9/h1-5H
InChIKey: CKTQPWIDUQGUGG-UHFFFAOYSA-N
SMILES: N1C2C(=CC(F)=CC=2)C(Cl)=CC=1
CAS DataBase Reference: 391-77-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-41-37/38
Safety Statements: 26-39
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BBO000711
Product name: 4-Chloro-6-fluoroquinoline
Packaging: 1G
Price: $99.7
Updated: 2023/06/20

Sigma-Aldrich

Product number: 758485
Product name: 4-Chloro-6-fluoroquinoline
Purity: 97%
Packaging: 1g
Price: $81.8
Updated: 2023/06/20

TCI Chemical

Product number: C2989
Product name: 4-Chloro-6-fluoroquinoline
Purity: >98.0%(GC)
Packaging: 1g
Price: $127
Updated: 2025/07/31

TCI Chemical

Product number: C2989
Product name: 4-Chloro-6-fluoroquinoline
Purity: >98.0%(GC)
Packaging: 5g
Price: $437
Updated: 2025/07/31

TRC

Product number: C989153
Product name: 4-Chloro-6-fluoroquinoline
Packaging: 100mg
Price: $75
Updated: 2021/12/16

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4-Chloro-6-fluoroquinoline Chemical Properties,Usage,Production

Application

4-Chloro-6-fluoroquinoline is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in laboratory research and development processes as well as in chemical and pharmaceutical synthesis.

Synthesis

38470-26-7

391-77-5

General procedure for the synthesis of 4-chloro-6-fluoroquinoline from 6-fluoro-2,3-dihydroquinolin-4(1H)-one: 412.55 mL of phosphoryl chloride, 11.5 g of iodine, and 165.0 g of manganese dioxide were added to a four-necked flask fitted with a stirrer and heated under stirring to 50 °C. Subsequently, 660 mL of a dichloroethane solution containing 165.02 g of 6-fluoro-2,3-dihydroquinolin-4(1H)-one was slowly added dropwise. After completion of the dropwise addition, the reaction mixture was refluxed for 2 hours. After completion of the reaction, the dichloroethane solvent was removed by distillation under reduced pressure. The residue was neutralized to pH 5-6 with cold aqueous sodium bicarbonate and filtered. The filter cake was washed with water to neutral and finally dried under vacuum to give 154.22 g of light gray solid 4-chloro-6-fluoroquinoline in 85.0% yield.

References

[1] Patent: CN106565602, 2017, A. Location in patent: Paragraph 0008; 0024; 0025; 0026; 0027

4-Chloro-6-fluoroquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Chloro-6-fluoroquinoline manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Chloro-6-fluoroquinoline 391-77-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Career Henan Chemical Co

Product: 4-Chloro-6-fluoroquinoline 391-77-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-08-14

391-77-5, 4-Chloro-6-fluoroquinolineRelated Search:

FLUOROLUBE GREASE, GR-362 Flucloxacillin Epichlorohydrin Cyhalothrin Fluroxypyr Flucloxacillin sodium λ-Cyhalothrin ETHYL 4-CHLORO-6,8-DIFLUOROQUINOLINE-3-CARBOXYLATE 4-CHLORO-6-FLUORO-2-METHYLQUINOLINE ETHYL 4-CHLORO-6-FLUOROQUINOLINE-3-CARBOXYLATE Chloroacetic acid 4-CHLORO-6,8-DIFLUOROQUINOLINE 4-CHLORO-6-FLUORO-2-(TRIFLUOROMETHYL)QUINOLINE 7-Chloro-8-fluoroquinoline 4-chloro-5-fluoroquinazoline hydrochloride ETHYL 4-CHLORO-6-FLUOROQUINOLINE-3-CARBOXYLATE 2-CHLORO-4-FLUOROQUINOLINE Difluorochloromethane

BUTTPARK 20\09-07

4-CHLORO-6-FLUOROQUINOLINE

EOS-62017

4-CHLORO-6-FLUOROQUINOLINE(WX900022)

4-Chloro-6-fluoroquinoline &gt

Quinoline, 4-chloro-6-fluoro-

4-Chloro-6-fluoroquinoline ISO 9001：2015 REACH

4-<WBR>Chloro-<WBR>6-<WBR>fluoroquinoline

391-77-5

361-77-5

C9H5ClFN

Quinoline&Isoquinoline