ChemicalBook > CAS DataBase List > A 33

A 33

Product Name
A 33
CAS No.
915082-52-9
Chemical Name
A 33
Synonyms
A-33;PDE4B-IN-2;PDE4B-IN-2, 10 mM in DMSO;Benzeneacetic acid, 4-[[2-(5-chloro-2-thienyl)-5-ethyl-6-methyl-4-pyrimidinyl]amino]-;2-(4-{[2-(5-chlorothiophen-2-yl)-5-ethyl-6-methylpyrimidin-4-yl]amino}phenyl)acetic acid
CBNumber
CB31124771
Molecular Formula
C19H18ClN3O2S
Formula Weight
387.88
MOL File
915082-52-9.mol
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A 33 Property

storage temp. 
Store at -20°C
solubility 
38.7mg/ml in DMSO
form 
Solid
color 
White to off-white
InChI
InChI=1S/C19H18ClN3O2S/c1-3-14-11(2)21-19(15-8-9-16(20)26-15)23-18(14)22-13-6-4-12(5-7-13)10-17(24)25/h4-9H,3,10H2,1-2H3,(H,24,25)(H,21,22,23)
InChIKey
FDVSPBLZPJMXFV-UHFFFAOYSA-N
SMILES
C1(CC(O)=O)=CC=C(NC2C(CC)=C(C)N=C(C3SC(Cl)=CC=3)N=2)C=C1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2121
Product name
A-33
Purity
≥98% (HPLC)
Packaging
5MG
Price
$108
Updated
2025/07/31
Sigma-Aldrich
Product number
SML2121
Product name
A-33
Purity
≥98% (HPLC)
Packaging
25MG
Price
$414.2
Updated
2025/07/31
Tocris
Product number
6313
Product name
A33
Purity
≥98%(HPLC)
Packaging
10
Price
$169
Updated
2021/12/16
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A 33 Chemical Properties,Usage,Production

Uses

PDE4B-IN-2 is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 μM). PDE4B-IN-2 exhibits potent anti-inflammatory effects[1].

Biochem/physiol Actions

A-33 (A33) is a potent and selective catalytic site-targeting PDE4B inhibitor (IC50 = 15 nM/PDE4B vs. 1.7 μM/PDE4D) that effectively prevents PDE4B-medicated cellular cAMP hydrolysis (150%/320% increased cAMP level with 100 nM/1 μM A-33 pre-treament in murine hippocampal HT-22 cells following 10 nM isoproterenol stimulation) in vitro and inhibits LPS-induced TNF-α production in mice in vivo (ID50 = 14 mg/kg p.o.). When administered via intraperitoneal injection, A-33 improves cognitive function in a rat model of traumatic brain injury (0.3 mg/kg i.p.) and exhibits antidepressant property in mice (0.3-1 mg/kg i.p.) in vivo.

in vivo

PDE4B-IN-2 (compound 33; 2 mg/kg; po) has a Cmax of 8.7 μg/mL and an AUC of 52.3 μg h/mL in mice[1].

IC 50

PDE4B: 15 nM (IC50); PDE4D: 1.7 μM (IC50)

storage

Store at -20°C

References

[1] Kenji Naganuma, et al. Discovery of selective PDE4B inhibitors. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3174-6. DOI:10.1016/j.bmcl.2009.04.121

A 33 Preparation Products And Raw materials

Raw materials

Preparation Products

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A 33 Suppliers

China 37 United States 4 Global 41
Wuhan Acumen Bio-Technology Co.,ltd
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027-027-16602739303 16602739303
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673003916@qq.com
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China
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BOC Sciences
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1-631-485-4226; 16314854226
Email
info@bocsci.com
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United States
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65
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
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4757
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BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
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65
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
Country
China
ProdList
71826
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Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
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QQ:1369748377
Email
sales@rechemscience.com
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China
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2987
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Shanghai SuperLan Chemcial Technique Centre
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0-2022843681 15618226720
Fax
+86-21-51601218
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chaolaichem@foxmail.com
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China
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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
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sales@glpbio.cn
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China
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6777
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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32435
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Changzhou Chenhong Biotechnology Co., Ltd.
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+86-0519-85788828 +86-13775037613
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sales@chemrenpharm.com
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China
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3934
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915082-52-9, A 33Related Search:


  • A-33
  • Benzeneacetic acid, 4-[[2-(5-chloro-2-thienyl)-5-ethyl-6-methyl-4-pyrimidinyl]amino]-
  • PDE4B-IN-2
  • 2-(4-{[2-(5-chlorothiophen-2-yl)-5-ethyl-6-methylpyrimidin-4-yl]amino}phenyl)acetic acid
  • PDE4B-IN-2, 10 mM in DMSO
  • 915082-52-9