a-Hydroxy Tamoxifen
- Product Name
- a-Hydroxy Tamoxifen
- CAS No.
- 97151-02-5
- Chemical Name
- a-Hydroxy Tamoxifen
- Synonyms
- α-OHTAM;α-OHTAM;α-hydroxy Tamoxifen;(E)-α-Hydroxy tamoxifen;(E)-α-Hydroxy Tamoxifen;(E)-(+/-)-alpha-Hydroxytamoxifen;Benzeneethanol,b-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]-a-methyl-,(bE)-;Benzeneethanol, β-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]-α-methyl-, (βE)-
- CBNumber
- CB31176114
- Molecular Formula
- C26H29NO2
- Formula Weight
- 387.52
- MOL File
- 97151-02-5.mol
a-Hydroxy Tamoxifen Property
- Melting point:
- 115-119°C
- Boiling point:
- 533.8±50.0 °C(Predicted)
- Density
- 1.094±0.06 g/cm3(Predicted)
- storage temp.
- Amber Vial, -20°C Freezer
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 14.13±0.20(Predicted)
- form
- Solid
- color
- Pale Yellow to Pale Beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 17204
- Product name
- α-hydroxy Tamoxifen
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 17204
- Product name
- α-hydroxy Tamoxifen
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 17204
- Product name
- α-hydroxy Tamoxifen
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $214
- Updated
- 2024/03/01
- Product number
- 17204
- Product name
- α-hydroxy Tamoxifen
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $335
- Updated
- 2024/03/01
- Product number
- H954700
- Product name
- (E)-α-HydroxyTamoxifen
- Packaging
- 10mg
- Price
- $145
- Updated
- 2021/12/16
a-Hydroxy Tamoxifen Chemical Properties,Usage,Production
Description
Tamoxifen is a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. Although it is an antagonist of ER action in breast tissue, it acts as an ER agonist in bone and blood vessels and a partial ER agonist in uterine tissues. α-hydroxy Tamoxifen is a reactive metabolite of tamoxifen that is formed by the action of cytochrome P450 3A4 in human liver. It can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety, which in rats has been linked with hepatocarcinoma.
Chemical Properties
Pale Yellow Solid
Uses
A metabolite of the chemotherapeutic drug Tamoxifen (T006000). Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Also active as an intramembranous inhibitor of lipid peroxidation.
Uses
A metabolite of the chemotherapeutic drug tamoxifen. Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Also active as an intramembranous inhibitor of lipid peroxidation.
Definition
ChEBI: Alpha-Hydroxytamoxifen is a stilbenoid.
a-Hydroxy Tamoxifen Preparation Products And Raw materials
Raw materials
Preparation Products
a-Hydroxy Tamoxifen Suppliers
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