ChemicalBook > CAS DataBase List > N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride

N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride

Product Name
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
CAS No.
1177141-67-1
Chemical Name
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
Synonyms
CKI-7 2HCL;CKI-7 dihydrochlorid;CKI-7 Dihydrochloride;CKI-7 (hydrochloride);N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride;N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride;Serum and glucocorticoid-regulated kinase,inhibit,nestin,S6K,Inhibitor,CK1,Casein Kinase,Ribosomal S6 Kinase (RSK),differentiation,SGK,CKI-7,Cyclin dependent kinase,neural,Serum-glucocorticoid regulated kinase,S6K1,MSK1,CDK,CKI 7,Wnt,CKI7,βIII-tubulin,Sox1
CBNumber
CB31176497
Molecular Formula
C11H14Cl3N3O2S
Formula Weight
358.67176
MOL File
1177141-67-1.mol
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N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride Property

Melting point:
187-189°C
storage temp. 
-20°C
solubility 
H2O: >5mg/mL
form 
solid
color 
white to light tan
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C0742
Product name
CKI-7 dihydrochloride
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$211
Updated
2024/03/01
Sigma-Aldrich
Product number
C0742
Product name
CKI-7 dihydrochloride
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$883
Updated
2024/03/01
Cayman Chemical
Product number
28268
Product name
CKI-7 (hydrochloride)
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
28268
Product name
CKI-7 (hydrochloride)
Packaging
25mg
Price
$533
Updated
2024/03/01
Cayman Chemical
Product number
28268
Product name
CKI-7 (hydrochloride)
Packaging
5mg
Price
$161
Updated
2024/03/01
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N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

Beige Solid

Uses

Found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases

Biochem/physiol Actions

CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. CKI-7 inhibits SGK as potently as CK1. IC50 = 6 μM.

storage

Store at -20°C

N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride Suppliers

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1177141-67-1, N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide DihydrochlorideRelated Search:

Choline kinase alpha 5-CHLOROISOQUINOLINE

  • CKI-7 Dihydrochloride
  • N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
  • CKI-7 dihydrochlorid
  • N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride
  • CKI-7 2HCL
  • Serum and glucocorticoid-regulated kinase,inhibit,nestin,S6K,Inhibitor,CK1,Casein Kinase,Ribosomal S6 Kinase (RSK),differentiation,SGK,CKI-7,Cyclin dependent kinase,neural,Serum-glucocorticoid regulated kinase,S6K1,MSK1,CDK,CKI 7,Wnt,CKI7,βIII-tubulin,Sox1
  • CKI-7 (hydrochloride)
  • 1177141-67-1
  • C11H14Cl3N3O2S
  • Inhibitors
  • Protein Kinase Inhibitors and Activators
  • All Inhibitors