ChemicalBook > CAS DataBase List > N-(2-HYDROXYETHYL)NITOTINAMIDE

N-(2-HYDROXYETHYL)NITOTINAMIDE

Product Name: N-(2-HYDROXYETHYL)NITOTINAMIDE
CAS No.: 6265-73-2
Chemical Name: N-(2-HYDROXYETHYL)NITOTINAMIDE
Synonyms: SG-86;Nicorandil Impurity 1;Nicorandil EP Impurity B;Hydroxyethylnicotinamide;Nicorandil EP Impurity 2;N-(2-hydroxyethyl)nicotinamide;N-(2-HYDROXYETHYL)NITOTINAMIDE;N-(2-hydroxyethyl)pyridine-3-carboxamide;N-(2-Hydroxyethyl)-3-Pyridine Carboxamide;3-Pyridinecarboxamide,N-(2-hydroxyethyl)-
CBNumber: CB31177348
Molecular Formula: C8H10N2O2
Formula Weight: 166.18
MOL File: 6265-73-2.mol

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N-(2-HYDROXYETHYL)NITOTINAMIDE Property

Melting point:: 92 °C
Boiling point:: 185-195 °C(Press: 0.4-0.6 Torr)
Density: 1.212±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
pka: 12.94±0.46(Predicted)
color: White to Pale Yellow
InChI: InChI=1S/C8H10N2O2/c11-5-4-10-8(12)7-2-1-3-9-6-7/h1-3,6,11H,4-5H2,(H,10,12)
InChIKey: SJZLOWYUGKIWAK-UHFFFAOYSA-N
SMILES: C1=NC=CC=C1C(NCCO)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: EME00383
Product name: <I>N</I>-(2-Hydroxyethyl)pyridine-3-carboxamide
Packaging: 1 g
Price: $569
Updated: 2025/07/31

TRC

Product number: H942365
Product name: N-(2-Hydroxyethyl)nicotinamide
Packaging: 250mg
Price: $105
Updated: 2021/12/16

Matrix Scientific

Product number: 074603
Product name: N-(2-Hydroxyethyl)nitotinamide
Purity: 95+%
Packaging: 250mg
Price: $278
Updated: 2021/12/16

Matrix Scientific

Product number: 074603
Product name: N-(2-Hydroxyethyl)nitotinamide
Purity: 95+%
Packaging: 1g
Price: $599
Updated: 2021/12/16

AK Scientific

Product number: W7469
Product name: N-(2-HYDROXYETHYL)NITOTINAMIDE
Packaging: 10g
Price: $608
Updated: 2021/12/16

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N-(2-HYDROXYETHYL)NITOTINAMIDE Chemical Properties,Usage,Production

Uses

N-(2-Hydroxyethyl)nitotinamide is an intermediate used to prepare oxadiazole oxide derivatives as vasodilators. It is also a derivative of Nicorandil (N398500) which is an antiaginal.

Synthesis

59-67-6

141-43-5

6265-73-2

The general procedure for the synthesis of N-(2-hydroxyethyl)-3-pyridinecarboxamide from nicotinic acid and 2-aminoethanol was as follows: suspension of nicotinic acid (0.385 g, 3.13 mmol) in anhydrous toluene (15 mL), addition of thionyl chloride (455 μL, 6.26 mmol), and refluxing of the reaction mixture for 4 hours at 140 °C. After cooling, a clarified solution was obtained and the solvent was removed in vacuum. The solid residue was washed three times with ether, followed by the addition of fresh anhydrous toluene (15 mL) and ethanolamine (756 μL, 12.52 mmol). The mixture was stirred at 50 °C overnight. Upon completion of the reaction, the solvent was removed under vacuum and the solid residue was purified by silica gel column chromatography using dichloromethane/methanol (9.2:0.8) as eluent. The final white solid product N-(2-hydroxyethyl)-3-pyridinecarboxamide (450 mg, 86% yield) was obtained with a melting point of 205 °C. The 1H NMR (300 MHz, DMSO-d6) data of the product were as follows: δ 9.00 (s, 1H, NH), 8.68 (m, 2H, Ar-H), 8.17 (d, 1H, Ar-H), 7.60 (m, 1H, Ar-H), 4.74 (m, 1H, OH), 3.51 (m, 2H, CH2), 3.36 (m, 2H CH2).

References

[1] Patent: WO2006/92204, 2006, A1. Location in patent: Page/Page column 16-17
[2] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 21, p. 5134 - 5147
[3] Archiv der Pharmazie, 2003, vol. 336, # 10, p. 445 - 455

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View Lastest Price from N-(2-HYDROXYETHYL)NITOTINAMIDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: N-(2-Hydroxyethyl)Nitotinamide 6265-73-2
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-17

Shaanxi Dideu Medichem Co. Ltd

Product: N-(2-HYDROXYETHYL)NITOTINAMIDE 6265-73-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-04-30

Henan Aochuang Chemical Co.,Ltd.

Product: N-(2-HYDROXYETHYL)NITOTINAMIDE 6265-73-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-13

6265-73-2, N-(2-HYDROXYETHYL)NITOTINAMIDERelated Search:

p-Nicorandil Nicorandil Impurity 2 N-[2-(ACETOXY)ETHYL]-3-PYRIDINECARBOXAMIDE nicopholine N-Nicotinoylglycine Nicorandil METHYL 2-[[(2-CHLORO-3-PYRIDYL)CARBONYL]AMINO]ACETATE METHYL 4-(METHYLTHIO)-2-([[2-(METHYLTHIO)-3-PYRIDYL]CARBONYL]AMINO)BUTANOATE N-[2-(METHYLTHIO)NICOTINOYL]-L-LEUCINE METHYL 2-([[2-(ETHYLTHIO)-3-PYRIDYL]CARBONYL]AMINO)-4-(METHYLTHIO)BUTANOATE (2S)-2-([(2-CHLOROPYRIDIN-3-YL)CARBONYL]AMINO)-4-(METHYLTHIO)BUTANOIC ACID DIETHYL 2-([(2-CHLORO-3-PYRIDYL)CARBONYL]AMINO)MALONATE MORPHOLINO[6-(1H-PYRAZOL-1-YL)-3-PYRIDINYL]METHANONE 3-methyl-2-[(pyridin-3-ylcarbonyl)amino]pentanoic acid (2-METHYL-1,6-NAPHTHYRIDIN-3-YL)MORPHOLINOMETHANONE ETHYL 2-METHYL-5-OXO-6-(2-([3-(TRIFLUOROMETHYL)BENZOYL]OXY)ETHYL)-5,6-DIHYDRO[1,6]NAPHTHYRIDINE-3-CARBOXYLATE ETHYL 6-(2-HYDROXYETHYL)-2-METHYL-5-OXO-5,6-DIHYDRO[1,6]NAPHTHYRIDINE-3-CARBOXYLATE N-(PYRIDIN-3-YLCARBONYL)METHIONINE

SG-86

Nicorandil Impurity 1

Nicorandil EP Impurity B

N-(2-HYDROXYETHYL)NITOTINAMIDE

N-(2-hydroxyethyl)nicotinamide

N-(2-Hydroxyethyl)-3-Pyridine Carboxamide

Nicorandil Impurity 2(Nicorandil EP Impurity B)

3-Pyridinecarboxamide,N-(2-hydroxyethyl)-

N-(2-hydroxyethyl)pyridine-3-carboxamide

N-(2-HYDROXYETHYL)NITOTINAMIDE ISO 9001：2015 REACH

Nicorandil EP Impurity B/Nicorandil Amide Imp

Hydroxyethylnicotinamide

Nicorandil EP Impurity 2

<i>N</i>-(2-Hydroxyethyl)pyridine-3-carboxamide

N-(2-hydroxyethyl)nitotinamide (Intermediate of Nicorandil)

6265-73-2