ChemicalBook > CAS DataBase List > N-(2-HYDROXYETHYL)NITOTINAMIDE

N-(2-HYDROXYETHYL)NITOTINAMIDE

Product Name
N-(2-HYDROXYETHYL)NITOTINAMIDE
CAS No.
6265-73-2
Chemical Name
N-(2-HYDROXYETHYL)NITOTINAMIDE
Synonyms
SG-86;Nicorandil Impurity 1;Nicorandil EP Impurity B;Hydroxyethylnicotinamide;Nicorandil EP Impurity 2;N-(2-hydroxyethyl)nicotinamide;N-(2-HYDROXYETHYL)NITOTINAMIDE;N-(2-hydroxyethyl)pyridine-3-carboxamide;N-(2-Hydroxyethyl)-3-Pyridine Carboxamide;3-Pyridinecarboxamide,N-(2-hydroxyethyl)-
CBNumber
CB31177348
Molecular Formula
C8H10N2O2
Formula Weight
166.18
MOL File
6265-73-2.mol
More
Less

N-(2-HYDROXYETHYL)NITOTINAMIDE Property

Melting point:
92 °C
Boiling point:
185-195 °C(Press: 0.4-0.6 Torr)
Density 
1.212±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
pka
12.94±0.46(Predicted)
color 
White to Pale Yellow
InChI
InChI=1S/C8H10N2O2/c11-5-4-10-8(12)7-2-1-3-9-6-7/h1-3,6,11H,4-5H2,(H,10,12)
InChIKey
SJZLOWYUGKIWAK-UHFFFAOYSA-N
SMILES
C1=NC=CC=C1C(NCCO)=O
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
EME00383
Product name
<I>N</I>-(2-Hydroxyethyl)pyridine-3-carboxamide
Packaging
1 g
Price
$569
Updated
2025/07/31
TRC
Product number
H942365
Product name
N-(2-Hydroxyethyl)nicotinamide
Packaging
250mg
Price
$105
Updated
2021/12/16
Matrix Scientific
Product number
074603
Product name
N-(2-Hydroxyethyl)nitotinamide
Purity
95+%
Packaging
250mg
Price
$278
Updated
2021/12/16
Matrix Scientific
Product number
074603
Product name
N-(2-Hydroxyethyl)nitotinamide
Purity
95+%
Packaging
1g
Price
$599
Updated
2021/12/16
AK Scientific
Product number
W7469
Product name
N-(2-HYDROXYETHYL)NITOTINAMIDE
Packaging
10g
Price
$608
Updated
2021/12/16
More
Less

N-(2-HYDROXYETHYL)NITOTINAMIDE Chemical Properties,Usage,Production

Uses

N-(2-Hydroxyethyl)nitotinamide is an intermediate used to prepare oxadiazole oxide derivatives as vasodilators. It is also a derivative of Nicorandil (N398500) which is an antiaginal.

Synthesis

59-67-6

141-43-5

6265-73-2

The general procedure for the synthesis of N-(2-hydroxyethyl)-3-pyridinecarboxamide from nicotinic acid and 2-aminoethanol was as follows: suspension of nicotinic acid (0.385 g, 3.13 mmol) in anhydrous toluene (15 mL), addition of thionyl chloride (455 μL, 6.26 mmol), and refluxing of the reaction mixture for 4 hours at 140 °C. After cooling, a clarified solution was obtained and the solvent was removed in vacuum. The solid residue was washed three times with ether, followed by the addition of fresh anhydrous toluene (15 mL) and ethanolamine (756 μL, 12.52 mmol). The mixture was stirred at 50 °C overnight. Upon completion of the reaction, the solvent was removed under vacuum and the solid residue was purified by silica gel column chromatography using dichloromethane/methanol (9.2:0.8) as eluent. The final white solid product N-(2-hydroxyethyl)-3-pyridinecarboxamide (450 mg, 86% yield) was obtained with a melting point of 205 °C. The 1H NMR (300 MHz, DMSO-d6) data of the product were as follows: δ 9.00 (s, 1H, NH), 8.68 (m, 2H, Ar-H), 8.17 (d, 1H, Ar-H), 7.60 (m, 1H, Ar-H), 4.74 (m, 1H, OH), 3.51 (m, 2H, CH2), 3.36 (m, 2H CH2).

References

[1] Patent: WO2006/92204, 2006, A1. Location in patent: Page/Page column 16-17
[2] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 21, p. 5134 - 5147
[3] Archiv der Pharmazie, 2003, vol. 336, # 10, p. 445 - 455

N-(2-HYDROXYETHYL)NITOTINAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-(2-HYDROXYETHYL)NITOTINAMIDE Suppliers

China 118 India 8 United States 7 Global 133
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58
SynZeal Research Pvt Ltd
Tel
--
Fax
--
Email
standards@synzeal.com
Country
India
ProdList
6514
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
More
Less

View Lastest Price from N-(2-HYDROXYETHYL)NITOTINAMIDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
N-(2-Hydroxyethyl)Nitotinamide 6265-73-2
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-07-17
Shaanxi Dideu Medichem Co. Ltd
Product
N-(2-HYDROXYETHYL)NITOTINAMIDE 6265-73-2
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-04-30
Henan Aochuang Chemical Co.,Ltd.
Product
N-(2-HYDROXYETHYL)NITOTINAMIDE 6265-73-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-13

6265-73-2, N-(2-HYDROXYETHYL)NITOTINAMIDERelated Search:

p-Nicorandil Nicorandil Impurity 2 N-[2-(ACETOXY)ETHYL]-3-PYRIDINECARBOXAMIDE nicopholine N-Nicotinoylglycine Nicorandil METHYL 2-[[(2-CHLORO-3-PYRIDYL)CARBONYL]AMINO]ACETATE METHYL 4-(METHYLTHIO)-2-([[2-(METHYLTHIO)-3-PYRIDYL]CARBONYL]AMINO)BUTANOATE N-[2-(METHYLTHIO)NICOTINOYL]-L-LEUCINE METHYL 2-([[2-(ETHYLTHIO)-3-PYRIDYL]CARBONYL]AMINO)-4-(METHYLTHIO)BUTANOATE (2S)-2-([(2-CHLOROPYRIDIN-3-YL)CARBONYL]AMINO)-4-(METHYLTHIO)BUTANOIC ACID DIETHYL 2-([(2-CHLORO-3-PYRIDYL)CARBONYL]AMINO)MALONATE MORPHOLINO[6-(1H-PYRAZOL-1-YL)-3-PYRIDINYL]METHANONE 3-methyl-2-[(pyridin-3-ylcarbonyl)amino]pentanoic acid (2-METHYL-1,6-NAPHTHYRIDIN-3-YL)MORPHOLINOMETHANONE ETHYL 2-METHYL-5-OXO-6-(2-([3-(TRIFLUOROMETHYL)BENZOYL]OXY)ETHYL)-5,6-DIHYDRO[1,6]NAPHTHYRIDINE-3-CARBOXYLATE ETHYL 6-(2-HYDROXYETHYL)-2-METHYL-5-OXO-5,6-DIHYDRO[1,6]NAPHTHYRIDINE-3-CARBOXYLATE N-(PYRIDIN-3-YLCARBONYL)METHIONINE

  • SG-86
  • Nicorandil Impurity 1
  • Nicorandil EP Impurity B
  • N-(2-HYDROXYETHYL)NITOTINAMIDE
  • N-(2-hydroxyethyl)nicotinamide
  • N-(2-Hydroxyethyl)-3-Pyridine Carboxamide
  • Nicorandil Impurity 2(Nicorandil EP Impurity B)
  • 3-Pyridinecarboxamide,N-(2-hydroxyethyl)-
  • N-(2-hydroxyethyl)pyridine-3-carboxamide
  • N-(2-HYDROXYETHYL)NITOTINAMIDE ISO 9001：2015 REACH
  • Nicorandil EP Impurity B/Nicorandil Amide Imp
  • Hydroxyethylnicotinamide
  • Nicorandil EP Impurity 2
  • <i>N</i>-(2-Hydroxyethyl)pyridine-3-carboxamide
  • N-(2-hydroxyethyl)nitotinamide (Intermediate of Nicorandil)
  • 6265-73-2