Defosfamide

Product Name
Defosfamide
CAS No.
3733-81-1
Chemical Name
Defosfamide
Synonyms
B-612;B 612;Mitarson;Defosfamide;Desmofosfamide;Desmophosphamidum;3-[[bis(2-chloroethyl)amino-(2-chloroethoxy)phosphoryl]amino]propan-1-ol;Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)-, 2-chloroethyl ester
CBNumber
CB31178431
Molecular Formula
C9H20Cl3N2O3P
Formula Weight
341.6
MOL File
3733-81-1.mol
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Defosfamide Property

Boiling point:
442.8±55.0 °C(Predicted)
Density 
1.337±0.06 g/cm3(Predicted)
pka
14.92±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0011177
Product name
DEFOSFAMIDE
Purity
95.00%
Packaging
5MG
Price
$497.98
Updated
2021/12/16
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Defosfamide Chemical Properties,Usage,Production

Originator

Mitarson,Asta-Werke,W. Germany,1961

Manufacturing Process

A solution of 8 g of ethylene chlorohydrin and 10.2 g of triethylamine in 50 cc of absolute dioxane is slowly added dropwise to a solution of 25.9 g of N,Nbis-(β-chloroethyl)-phosphoric acid amide dichloride in 100 cc of absolute dioxane. The mixture is then heated for 2 hours at 60°C. After cooling, a solution of 7.5 g of 1,3-propanolamine and 10.2 g of triethylamine in 50 cc of absolute dioxane is added dropwise while stirring well and at a temperature up to 30°C. The mixture is left to stand for another 12 hours. The liquid is filtered off with suction from the precipitated triethyamine hydrochloride. The filtrate is filtered through carbon and concentrated by evaporation in water-jet vacuum at 40°C. The residue is dissolved in a little alcohol. Copious amounts of ether are added and the solution is left overnight in a refrigerator. It is then again filtered through carbon, the ether is evaporated and the residual volatile fractions are removed under high vacuum at 55°C. The result is a yellowish, fairly viscous oil, which is insoluble in water.

Therapeutic Function

Antineoplastic

Defosfamide Preparation Products And Raw materials

Raw materials

Preparation Products

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Defosfamide Suppliers

Career Henan Chemica Co
Tel
+86-0371-86658258 15093356674;
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30255
Advantage
58

3733-81-1, DefosfamideRelated Search:


  • Defosfamide
  • B 612
  • B-612
  • Desmofosfamide
  • Desmophosphamidum
  • Mitarson
  • 3-[[bis(2-chloroethyl)amino-(2-chloroethoxy)phosphoryl]amino]propan-1-ol
  • Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)-, 2-chloroethyl ester
  • 3733-81-1
  • C9H20Cl3N2O3P