ChemicalBook > CAS DataBase List > phosphoramide mustard
phosphoramide mustard
- Product Name
- phosphoramide mustard
- CAS No.
- 10159-53-2
- Chemical Name
- phosphoramide mustard
- Synonyms
- phosphoramide mustard;Phosphoramide Mustard D8
- CBNumber
- CB01386806
- Molecular Formula
- C4H11Cl2N2O2P
- Formula Weight
- 221.02
- MOL File
- 10159-53-2.mol
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phosphoramide mustard Property
- Melting point:
- 115 °C
- Boiling point:
- 363.5±52.0 °C(Predicted)
- Density
- 1.474±0.06 g/cm3(Predicted)
- pka
- 0.41±0.50(Predicted)
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Safety
- Toxicity
- LD50 intraperitoneal in mouse: 184mg/kg
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phosphoramide mustard Chemical Properties,Usage,Production
Definition
ChEBI: Phosphoramide mustard is a nitrogen mustard and a phosphorodiamide.
Biological Activity
Phosphoramide mustard is the active metabolite of cyclophosphamide (HY-17420) with antitumor activity. It induces DNA damage.
in vitro
Phosphoramide mustard causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication.
It (3-6 μM; 48 hours) reduces cell viability in rat spontaneously immortalized granulosa cells ( SIGCs).
Phosphoramide mustard (3-6 μM; 24-48 hours) induces DNA adduct formation and ovarian DNA damage.
It (3-6 μM; 24-48 hours) increases DNA damage responses (DDR) gene mRNA expression levels and DDR proteins.
Cell Viability Assay
| Cell Line: | SIGCs |
| Concentration: | 0.5 μM, 1 μM, 3 μM, 6 μM |
| Incubation Time: | 48 hours |
| Result: | Reduced ce ll viability at concentrations of 3 μM and higher. |
RT-PCR
| Cell Line: | SIGCs |
| Concentration: | 3 μM, 6 μM |
| Incubation Time: | 24 hours, 48 hours |
| Result: | Increased DDR gene mRNA expression levels. |
Western Blot Analysis
| Cell Line: | SIGCs | < /tr>
| Concentration: | 3 μM, 6 μM |
| Incubation Time: | 24 hours, 48 hours |
| Result: | Generally increased DDR pro teins. |
target
DNA Alkylator
phosphoramide mustard Preparation Products And Raw materials
Raw materials
Preparation Products
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10159-53-2, phosphoramide mustardRelated Search:
Cyclophosphamide monohydrate
4-HYDROPEROXY CYCLOPHOSPHAMIDE
Mafosfamide
Cyclophosphamide
Defosfamide
trofosfamide
alcophosphamide
carboxyphosphamide
4-hydroxycyclophosphamide
phosphoramide mustard
B 749
5,5-dimethylcyclophosphamide
trans-5-Fluorocyclophosphamide
Mafosfamide cyclohexylamine salt
Carbamic acid, ((2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazap hosphorin-4-yl)oxy)-, phenylmethyl ester, P-oxide
2H-1,3,2-Oxazaphosphorine, tetrahydro-2-(bis(2-chloroethyl)amino)-5-ch loro-, 2-oxide, (Z)-
4-S-(Propionic acid)sulfidocyclophosphamide
4-(S-Ethanol)-sulfido-cyclophosphamide