phosphoramide mustard

Product Name: phosphoramide mustard
CAS No.: 10159-53-2
Chemical Name: phosphoramide mustard
Synonyms: phosphoramide mustard;Phosphoramide Mustard D8
CBNumber: CB01386806
Molecular Formula: C4H11Cl2N2O2P
Formula Weight: 221.02
MOL File: 10159-53-2.mol

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phosphoramide mustard Property

Melting point:: 115 °C
Boiling point:: 363.5±52.0 °C(Predicted)
Density: 1.474±0.06 g/cm3(Predicted)
pka: 0.41±0.50(Predicted)

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Safety

Toxicity: LD50 intraperitoneal in mouse: 184mg/kg

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Hazard and Precautionary Statements (GHS)

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phosphoramide mustard Chemical Properties,Usage,Production

Definition

ChEBI: Phosphoramide mustard is a nitrogen mustard and a phosphorodiamide.

Biological Activity

Phosphoramide mustard is the active metabolite of cyclophosphamide (HY-17420) with antitumor activity. It induces DNA damage.

in vitro

Phosphoramide mustard causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication.
It (3-6 μM; 48 hours) reduces cell viability in rat spontaneously immortalized granulosa cells ( SIGCs).
Phosphoramide mustard (3-6 μM; 24-48 hours) induces DNA adduct formation and ovarian DNA damage.
It (3-6 μM; 24-48 hours) increases DNA damage responses (DDR) gene mRNA expression levels and DDR proteins.

Cell Viability Assay

Cell Line:	SIGCs
Concentration:	0.5 μM, 1 μM, 3 μM, 6 μM
Incubation Time:	48 hours
Result:	Reduced ce ll viability at concentrations of 3 μM and higher.

RT-PCR

Cell Line:	SIGCs
Concentration:	3 μM, 6 μM
Incubation Time:	24 hours, 48 hours
Result:	Increased DDR gene mRNA expression levels.

Western Blot Analysis

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Cell Line:	SIGCs
Concentration:	3 μM, 6 μM
Incubation Time:	24 hours, 48 hours
Result:	Generally increased DDR pro teins.

target

DNA Alkylator

phosphoramide mustard Preparation Products And Raw materials

Raw materials

Preparation Products

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phosphoramide mustard Suppliers

China 7 India 1 United States 1 Global 9

Chizhou Kailong Import and Export Trade Co., Ltd.

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Shenzhen Regent Biochemical Technology Co., Ltd.

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AFINE CHEMICALS LIMITED

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Guangzhou Yunmen Biotechnology Co., Ltd

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Guangdong Fangxin Biotechnology Co., Ltd.

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Henan Tianfu Chemical Co.,Ltd.

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PT CHEM GROUP LIMITED

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10159-53-2, phosphoramide mustardRelated Search:

Cyclophosphamide monohydrate 4-HYDROPEROXY CYCLOPHOSPHAMIDE Mafosfamide Cyclophosphamide Defosfamide trofosfamide alcophosphamide carboxyphosphamide 4-hydroxycyclophosphamide phosphoramide mustard B 749 5,5-dimethylcyclophosphamide trans-5-Fluorocyclophosphamide Mafosfamide cyclohexylamine salt Carbamic acid, ((2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazap hosphorin-4-yl)oxy)-, phenylmethyl ester, P-oxide 2H-1,3,2-Oxazaphosphorine, tetrahydro-2-(bis(2-chloroethyl)amino)-5-ch loro-, 2-oxide, (Z)- 4-S-(Propionic acid)sulfidocyclophosphamide 4-(S-Ethanol)-sulfido-cyclophosphamide

phosphoramide mustard

Phosphoramide Mustard D8

10159-53-2