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Cyclophosphamide monohydrate

Product Name
Cyclophosphamide monohydrate
CAS No.
6055-19-2
Chemical Name
Cyclophosphamide monohydrate
Synonyms
CPA;Cyclophosphamide sterile;CYTOXAN;ENDOXON;Procy-tox;Cycloblastin;-2monohydrate;endoxanmonohydrate;TIMTEC-BB SBB003026;cyclophosphamide，CTX
CBNumber
CB5345867
Molecular Formula
C7H17Cl2N2O3P
Formula Weight
279.1
MOL File
6055-19-2.mol
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Cyclophosphamide monohydrate Property

Melting point:
49-51 °C (lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
H2O: 0.1 g/mL, clear, colorless
form 
Crystals or Crystalline Powder
color 
White to almost white
Water Solubility 
40 g/L
Merck 
14,2747
BRN 
8167897
Stability:
Hygroscopic
InChIKey
PWOQRKCAHTVFLB-UHFFFAOYSA-N
CAS DataBase Reference
6055-19-2(CAS DataBase Reference)
IARC
1 (Vol. 26, Sup 7, 100A) 2012
EPA Substance Registry System
Cyclophosphamide monohydrate (6055-19-2)
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Safety

Hazard Codes 
T
Risk Statements 
45-25-61-46-36/37/38-23/24/25
Safety Statements 
53-45-37/39-26
RIDADR 
UN 3464 6.1/PG 3
WGK Germany 
3
RTECS 
RP6157750
F 
10
HazardClass 
6.1
PackingGroup 
II
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H340May cause genetic defects

H350May cause cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
93813
Product name
Cyclophosphamide monohydrate
Purity
analytical standard
Packaging
100mg
Price
$69.5
Updated
2024/03/01
Sigma-Aldrich
Product number
239785
Product name
CyclophosphamideMonohydrate-CAS6055-19-2-Calbiochem
Purity
Awidelyusedanti-neoplasticagentthatalsodisplaysimmunosuppressantpropert
Packaging
1g
Price
$111
Updated
2024/03/01
TCI Chemical
Product number
C2236
Product name
Cyclophosphamide Monohydrate
Purity
>98.0%(N)
Packaging
5g
Price
$114
Updated
2024/03/01
TCI Chemical
Product number
C2236
Product name
Cyclophosphamide Monohydrate
Purity
>98.0%(N)
Packaging
25g
Price
$385
Updated
2024/03/01
Cayman Chemical
Product number
13849
Product name
Cyclophosphamide (hydrate)
Purity
≥98%
Packaging
1g
Price
$32
Updated
2024/03/01
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Cyclophosphamide monohydrate Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.

Uses

antineoplastic, alkylating agent

Uses

An immunosuppressive, cytotoxic apoptosis inducer.

Uses

Cyclophosphamide monohydrate is used to treat cancers, autoimmune disorders and AL amyloidosis. It is a nitrogen mustard alkylating agent and reacts with deoxyribonucleic acid (DNA) to get its alkylated derivative. It is also involved in cancer research as a tool that induces apoptosis in tumor cells.

Uses

alkylating agent in cancer therapy

Definition

ChEBI: The monohydrate of cyclophosphamide.

brand name

Cytoxan (Bristol-Myers Squibb); Neosar (Sicor).

General Description

Fine white crystalline powder with a slightly bitter taste. Little or no odor.

Air & Water Reactions

Water soluble. Sensitive to moisture and light. Aqueous solutions may be kept for a few hours above room temperature, but hydrolysis occurs at temperatures above 86°F. Cyclophosphamide monohydrate undergoes both specific acid and specific base catalysis at extreme pHs. Spontaneous hydrolysis in aqueous solutions.

Reactivity Profile

Polymerization can occur at temperatures > 120° F. Cyclophosphamide monohydrate reacts with strong oxidizing agents, strong acids and strong bases. Benzyl alcohol increases rate of hydrolysis.

Fire Hazard

Cyclophosphamide monohydrate is probably combustible.

Biochem/physiol Actions

Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.

Safety Profile

Confirmed human carcinogen. Poison by ingestion and intravenous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl-, PO,, and NOx.

Cyclophosphamide monohydrate Preparation Products And Raw materials

Raw materials

Diethanolamine

Preparation Products

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Cyclophosphamide monohydrate Suppliers

Americas 1 Belgium 2 Canada 1 China 331 Europe 3 France 1 Germany 4 India 21 Japan 4 Poland 1 Russia 1 Switzerland 3 United Kingdom 13 United States 48 Global 434
Shandong Platinum Pharmaceutical Co., Ltd.
Tel
0531-0531-69954981 88963280 15666777973
Fax
0531-88964879
Email
sales@boyuanpharm.com
Country
China
ProdList
208
Advantage
58
Nanjing Daqin Pharmaceutical Technology Co., Ltd.
Tel
025-58470199 18351831988
Fax
025-58470199
Email
sales@daqinpharma.com
Country
China
ProdList
312
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2210
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
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69
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1998
Advantage
65
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6011
Advantage
61
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
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View Lastest Price from Cyclophosphamide monohydrate manufacturers

Hebei Saisier Technology Co., LTD
Product
Cyclophosphamide monohydrate 6055-19-2
Price
US $6.00/KG
Min. Order
1KG
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-04-24
Henan Fengda Chemical Co., Ltd
Product
Cyclophosphamide monohydrate 6055-19-2
Price
US $35.00-1.10/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-19
Hebei Jingbo New Material Technology Co., Ltd
Product
Cyclophosphamide monohydrate 6055-19-2
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20000
Release date
2023-12-29

6055-19-2, Cyclophosphamide monohydrateRelated Search:

MELIBIOSE NITRIC OXIDE Polyamide Rink Amide Linker BUTYL OLEATE Dibenzylamine Tris(trimethylsilyl)phosphate Methyl acrylate Bis(2-ethylhexyl)amine Triallylamine Ethylcyclohexane Fomesafen (Diethoxymethyl)diphenylphosphine oxide Ifosfamide Cyclophosphamide Mafosfamide 4-HYDROPEROXY CYCLOPHOSPHAMIDE IFOSFAMIDE IMPURITY F

  • 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE
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  • 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE MONOHYDRATE
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  • n,n-bis(beta-chloroethyl)-n',o-propylenephosphoric acid ester amide monohydrate
  • TIMTEC-BB SBB003026
  • > 100 Kgyclophosphamide monohydrate
  • Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester~Cyclophosphane
  • cyclophosphamide isopac
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  • CYCLOPHOSPHAMIDE 1-HYDRATE
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  • CyclophosphaMide,awater
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  • 2-oxide-N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine, hydrate (1:1)
  • Bis(2-chloroethyl)phosphoramide cyclic propanolamide este
  • Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester m
  • (bis(chloro-2-ethyl)amino)-2-tetrahydro-3,4,5,6-oxazaphosphorine-1,3,2-oxide
  • 1-bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridinemonohydrate
  • 2-(bis(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphocyclohexane2-oxidemonohydr
  • 2-(di(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphacyclohexane-2-oxidemonohydra
  • 2h-1,3,2-oxazaphosphorine,tetrahydro-2-(bis(2-chloroethyl)amino)-,2-oxide,mo
  • -2monohydrate
  • cyclicn’,o-propyleneesterofn,n-bis(2-chloroethyl)phosphorodiamidicacidm
  • endoxanmonohydrate
  • n,n-bis(2-chloroethyl)tetrahydro-2h-1,3,2-oxaphosphorin-2-amine,2-oxidemono
  • N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphos-phorin-2-amine2-oxide
  • n,n-bis(beta-chloroethyl)-n’,o-propylenephosphoricacidesteramidemonohydra
  • n,n-bis(beta-chloroethyl)-n’,o-trimethylenephosphoricacidesterdiamidemono
  • Procy-tox
  • n,n-bis(beta-cloraethyl)n’-o-propylenphosphorildiamidmonohydratum
  • N,N-Bis-2-chloroethyl-N’,O-propylenephosphoricesterdiamidemonohydrate
  • n,n-di(2-chloroethyl)amino-n,o-propylenephosphoricacidesterdiamidemonohy
  • CYCLOPHOPHAMIDEMONOHYDRATE
  • CYCLOPHOSPHAMIDE,MONOHYDRATE,USP
  • CYCLOPHOSPHAMIDE(HYDRATED)
  • cyclophosphamide，CTX
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  • Cycloblastin
  • Cyclophosphamide monohydrate, 97+%
  • Cytoxan, 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
  • 2H-1,3,2-Oxazaphosphorine, tetrahydro-2-(bis(2-chloroethyl)amino)-, 2-oxide, monohydrate
  • N,N-Bis(2-chloroethyl)-2-oxo-1-oxa-3-aza-2$l^{5}-phosphacyclohexan-2-amine hydrate
  • CyclophosphamideUsp27
  • Cyclophosphamide monohydrate,2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan
  • Cyclophosphamide (500 mg) (FOR U.S. SALE ONLY)