ChemicalBook > CAS DataBase List > Cyclophosphamide monohydrate

Cyclophosphamide monohydrate

Product Name
Cyclophosphamide monohydrate
CAS No.
6055-19-2
Chemical Name
Cyclophosphamide monohydrate
Synonyms
CPA;Cyclophosphamide sterile;CYTOXAN;ENDOXON;Procy-tox;Cycloblastin;-2monohydrate;endoxanmonohydrate;TIMTEC-BB SBB003026;cyclophosphamide，CTX
CBNumber
CB5345867
Molecular Formula
C7H17Cl2N2O3P
Formula Weight
279.1
MOL File
6055-19-2.mol
More
Less

Cyclophosphamide monohydrate Property

Melting point:
49-51 °C (lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
H2O: 0.1 g/mL, clear, colorless
form 
Crystals or Crystalline Powder
color 
White to almost white
Water Solubility 
40 g/L
Merck 
14,2747
BRN 
8167897
Stability:
Hygroscopic
InChIKey
PWOQRKCAHTVFLB-UHFFFAOYSA-N
CAS DataBase Reference
6055-19-2(CAS DataBase Reference)
IARC
1 (Vol. 26, Sup 7, 100A) 2012
EPA Substance Registry System
Cyclophosphamide monohydrate (6055-19-2)
More
Less

Safety

Hazard Codes 
T
Risk Statements 
45-25-61-46-36/37/38-23/24/25
Safety Statements 
53-45-37/39-26
RIDADR 
UN 3464 6.1/PG 3
WGK Germany 
3
RTECS 
RP6157750
F 
10
HazardClass 
6.1
PackingGroup 
II
HS Code 
29349990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H340May cause genetic defects

H350May cause cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
93813
Product name
Cyclophosphamide monohydrate
Purity
analytical standard
Packaging
100mg
Price
$69.5
Updated
2024/03/01
Sigma-Aldrich
Product number
239785
Product name
CyclophosphamideMonohydrate-CAS6055-19-2-Calbiochem
Purity
Awidelyusedanti-neoplasticagentthatalsodisplaysimmunosuppressantpropert
Packaging
1g
Price
$111
Updated
2024/03/01
TCI Chemical
Product number
C2236
Product name
Cyclophosphamide Monohydrate
Purity
>98.0%(N)
Packaging
5g
Price
$114
Updated
2024/03/01
TCI Chemical
Product number
C2236
Product name
Cyclophosphamide Monohydrate
Purity
>98.0%(N)
Packaging
25g
Price
$385
Updated
2024/03/01
Cayman Chemical
Product number
13849
Product name
Cyclophosphamide (hydrate)
Purity
≥98%
Packaging
1g
Price
$32
Updated
2024/03/01
More
Less

Cyclophosphamide monohydrate Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.

Uses

antineoplastic, alkylating agent

Uses

An immunosuppressive, cytotoxic apoptosis inducer.

Uses

Cyclophosphamide monohydrate is used to treat cancers, autoimmune disorders and AL amyloidosis. It is a nitrogen mustard alkylating agent and reacts with deoxyribonucleic acid (DNA) to get its alkylated derivative. It is also involved in cancer research as a tool that induces apoptosis in tumor cells.

Uses

alkylating agent in cancer therapy

Definition

ChEBI: The monohydrate of cyclophosphamide.

brand name

Cytoxan (Bristol-Myers Squibb); Neosar (Sicor).

General Description

Fine white crystalline powder with a slightly bitter taste. Little or no odor.

Air & Water Reactions

Water soluble. Sensitive to moisture and light. Aqueous solutions may be kept for a few hours above room temperature, but hydrolysis occurs at temperatures above 86°F. Cyclophosphamide monohydrate undergoes both specific acid and specific base catalysis at extreme pHs. Spontaneous hydrolysis in aqueous solutions.

Reactivity Profile

Polymerization can occur at temperatures > 120° F. Cyclophosphamide monohydrate reacts with strong oxidizing agents, strong acids and strong bases. Benzyl alcohol increases rate of hydrolysis.

Fire Hazard

Cyclophosphamide monohydrate is probably combustible.

Biochem/physiol Actions

Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.

Safety Profile

Confirmed human carcinogen. Poison by ingestion and intravenous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl-, PO,, and NOx.

Cyclophosphamide monohydrate Preparation Products And Raw materials

Raw materials

Diethanolamine

Preparation Products

More
Less

Cyclophosphamide monohydrate Suppliers

Americas 1 Belgium 2 Canada 1 China 332 Europe 3 France 1 Germany 4 India 21 Japan 4 Poland 1 Russia 1 Switzerland 3 United Kingdom 13 United States 48 Global 435
Shandong Platinum Pharmaceutical Co., Ltd.
Tel
0531-0531-69954981 88963280 15963125531
Fax
0531-88964879
Email
sales@boyuanpharm.com
Country
China
ProdList
223
Advantage
58
Nanjing Daqin Pharmaceutical Technology Co., Ltd.
Tel
025-58470199 18351831988
Fax
025-58470199
Email
sales@daqinpharma.com
Country
China
ProdList
312
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2210
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94838
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1998
Advantage
65
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6011
Advantage
61
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18501085097
Fax
010-89508210
Email
sales3.gd@hwrkchemical.com
Country
China
ProdList
7639
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
Advantage
52
Shandong Xiya Chemical Co., Ltd
Tel
13355009207 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18739
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Wuhan Fortuna Chemical Co., Ltd
Tel
027-027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2893
Advantage
58
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4647
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4941
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6139
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22519
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
Shanghai Ruji Biology Technology Co., Ltd.
Tel
+86-21-65211385-8001 36031160
Fax
+86-21-65211385-8004
Email
sales@shruji.com
Country
China
ProdList
3224
Advantage
55
China Nobel Chem Co., Limited
Tel
+86(0)21 60484900
Fax
+86(0)21 60484900
Country
China
ProdList
764
Advantage
50
Nanjing Dulai Biotechnology Co., Ltd.
Tel
025-84699383-8003 18013301590
Fax
025-84699383-8003
Email
njduly@126.com
Country
China
ProdList
973
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3123
Advantage
55
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9986
Advantage
55
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4928
Advantage
55
ALPENGLOW CHEMICAL INDUSTRIAL CO., LTD
Tel
086-0531-86986713
Fax
086-0531-86980810
Email
aplgroup@163.com
Country
China
ProdList
96
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
Shanghai DiBai Chemicals Co., Ltd.
Tel
021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3993
Advantage
60
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7892
Advantage
56
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13358
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9636
Advantage
58
NINGBO INNO PHARMCHEM CO.,LTD.
Tel
86-574-27787657
Fax
86-574-27912196
Email
info@dearchem.com
Country
China
ProdList
4619
Advantage
58
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5223
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4951
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10287
Advantage
55
Shanghai Xingui Biotechnology Co., Ltd.
Tel
17501653713 17501653715
Email
xingui2022@126.com
Country
China
ProdList
10033
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15878
Advantage
55
More
Less

View Lastest Price from Cyclophosphamide monohydrate manufacturers

Hebei Saisier Technology Co., LTD
Product
Cyclophosphamide monohydrate 6055-19-2
Price
US $6.00/KG
Min. Order
1KG
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-04-24
Henan Fengda Chemical Co., Ltd
Product
Cyclophosphamide monohydrate 6055-19-2
Price
US $35.00-1.10/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-19
Hebei Jingbo New Material Technology Co., Ltd
Product
Cyclophosphamide monohydrate 6055-19-2
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20000
Release date
2023-12-29

6055-19-2, Cyclophosphamide monohydrateRelated Search:

MELIBIOSE NITRIC OXIDE Polyamide Rink Amide Linker BUTYL OLEATE Dibenzylamine Tris(trimethylsilyl)phosphate Methyl acrylate Bis(2-ethylhexyl)amine Triallylamine Ethylcyclohexane Fomesafen (Diethoxymethyl)diphenylphosphine oxide Ifosfamide Cyclophosphamide Mafosfamide 4-HYDROPEROXY CYCLOPHOSPHAMIDE IFOSFAMIDE IMPURITY F

  • 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE
  • 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE HYDRATE
  • 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE MONOHYDRATE
  • CPA
  • ENDOXON
  • CYTOXAN
  • CYCLOPHOSPHAMIDE HYDRATE
  • CYCLOPHOSPHAMIDE MONOHYDRATE
  • CYCLOPHOSPHAMID MONOHYDRATE
  • bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate
  • N,N-BIS(2-CHLOROETHYL)TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORIN-2-AMINE-2-OXIDE MONOHYDRATE
  • n,n-bis(beta-chloroethyl)-n',o-propylenephosphoric acid ester amide monohydrate
  • TIMTEC-BB SBB003026
  • > 100 Kgyclophosphamide monohydrate
  • Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester~Cyclophosphane
  • cyclophosphamide isopac
  • Cyclophosphamide sterile
  • Cyclophos phamide USP
  • CYCLOPHOSPHAMIDE MONOHYDRATE, 98+%
  • CyclophosphamideSterile,Usp28
  • Cyclophosphamidemonohaydrate
  • Cyclophosphamide monohydrate, 97%, a nitrogen mustard alkylating agent
  • CYCLOPHOSPHAMIDE 1-HYDRATE
  • 2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide, monohydrate
  • CyclophosphaMide,awater
  • 2-(Bis(2-chloroethyl)aMino)-1,3,2-oxazaphosphinane 2-oxide hydrate
  • 2-oxide-N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine, hydrate (1:1)
  • Bis(2-chloroethyl)phosphoramide cyclic propanolamide este
  • Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester m
  • (bis(chloro-2-ethyl)amino)-2-tetrahydro-3,4,5,6-oxazaphosphorine-1,3,2-oxide
  • 1-bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridinemonohydrate
  • 2-(bis(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphocyclohexane2-oxidemonohydr
  • 2-(di(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphacyclohexane-2-oxidemonohydra
  • 2h-1,3,2-oxazaphosphorine,tetrahydro-2-(bis(2-chloroethyl)amino)-,2-oxide,mo
  • -2monohydrate
  • cyclicn’,o-propyleneesterofn,n-bis(2-chloroethyl)phosphorodiamidicacidm
  • endoxanmonohydrate
  • n,n-bis(2-chloroethyl)tetrahydro-2h-1,3,2-oxaphosphorin-2-amine,2-oxidemono
  • N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphos-phorin-2-amine2-oxide
  • n,n-bis(beta-chloroethyl)-n’,o-propylenephosphoricacidesteramidemonohydra
  • n,n-bis(beta-chloroethyl)-n’,o-trimethylenephosphoricacidesterdiamidemono
  • Procy-tox
  • n,n-bis(beta-cloraethyl)n’-o-propylenphosphorildiamidmonohydratum
  • N,N-Bis-2-chloroethyl-N’,O-propylenephosphoricesterdiamidemonohydrate
  • n,n-di(2-chloroethyl)amino-n,o-propylenephosphoricacidesterdiamidemonohy
  • CYCLOPHOPHAMIDEMONOHYDRATE
  • CYCLOPHOSPHAMIDE,MONOHYDRATE,USP
  • CYCLOPHOSPHAMIDE(HYDRATED)
  • cyclophosphamide，CTX
  • 2h-1,3,2-oxazaphosphorine, tetrahydro-2-(bis(2-chloroethyl)amino)-, 2-oxide, mo (bis(chloro-2-ethyl)amino)-2-tetrahydro-3,4,5,6-oxazaphosphorine-1,3,2-o xide 1-bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridine monohydrate 2-(bis(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphocyclohexane 2-oxide monohydr 2-(di(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphacyclohexane-2-oxide monohydra cyclophosphamide hydrate cyclophosphamide monohydrate endoxan monohydrate
  • Cycloblastin
  • Cyclophosphamide monohydrate, 97+%
  • Cytoxan, 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
  • 2H-1,3,2-Oxazaphosphorine, tetrahydro-2-(bis(2-chloroethyl)amino)-, 2-oxide, monohydrate
  • N,N-Bis(2-chloroethyl)-2-oxo-1-oxa-3-aza-2$l^{5}-phosphacyclohexan-2-amine hydrate
  • CyclophosphamideUsp27
  • Cyclophosphamide monohydrate,2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan
  • Cyclophosphamide (500 mg) (FOR U.S. SALE ONLY)