Cyclophosphamide monohydrate Property

Melting point:

49-51 °C (lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

H₂O: 0.1 g/mL, clear, colorless

form 

Crystals or Crystalline Powder

color 

White to almost white

Water Solubility 

40 g/L

Merck 

14,2747

BRN 

8167897

Stability:

Hygroscopic

InChIKey

PWOQRKCAHTVFLB-UHFFFAOYSA-N

CAS DataBase Reference

6055-19-2(CAS DataBase Reference)

IARC

1 (Vol. 26, Sup 7, 100A) 2012

EPA Substance Registry System

Cyclophosphamide monohydrate (6055-19-2)

Safety

Hazard Codes 

T

Risk Statements 

45-25-61-46-36/37/38-23/24/25

Safety Statements 

53-45-37/39-26

RIDADR 

UN 3464 6.1/PG 3

WGK Germany 

3

RTECS 

RP6157750

F 

10

HazardClass 

6.1

PackingGroup 

II

HS Code 

29349990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H340May cause genetic defects

H350May cause cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

Cyclophosphamide monohydrate Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.

Uses

antineoplastic, alkylating agent

Uses

An immunosuppressive, cytotoxic apoptosis inducer.

Uses

Cyclophosphamide monohydrate is used to treat cancers, autoimmune disorders and AL amyloidosis. It is a nitrogen mustard alkylating agent and reacts with deoxyribonucleic acid (DNA) to get its alkylated derivative. It is also involved in cancer research as a tool that induces apoptosis in tumor cells.

Uses

alkylating agent in cancer therapy

Definition

ChEBI: The monohydrate of cyclophosphamide.

brand name

Cytoxan (Bristol-Myers Squibb); Neosar (Sicor).

General Description

Fine white crystalline powder with a slightly bitter taste. Little or no odor.

Air & Water Reactions

Water soluble. Sensitive to moisture and light. Aqueous solutions may be kept for a few hours above room temperature, but hydrolysis occurs at temperatures above 86°F. Cyclophosphamide monohydrate undergoes both specific acid and specific base catalysis at extreme pHs. Spontaneous hydrolysis in aqueous solutions.

Reactivity Profile

Polymerization can occur at temperatures > 120° F. Cyclophosphamide monohydrate reacts with strong oxidizing agents, strong acids and strong bases. Benzyl alcohol increases rate of hydrolysis.

Fire Hazard

Cyclophosphamide monohydrate is probably combustible.

Biochem/physiol Actions

Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.

Safety Profile

Confirmed human carcinogen. Poison by ingestion and intravenous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl-, PO,, and NOx.