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Cyclophosphamide monohydrate

Product Name
Cyclophosphamide monohydrate
CAS No.
6055-19-2
Chemical Name
Cyclophosphamide monohydrate
Synonyms
CPA;Cyclophosphamide sterile;CYTOXAN;ENDOXON;Procy-tox;Cycloblastin;-2monohydrate;endoxanmonohydrate;TIMTEC-BB SBB003026;cyclophosphamide，CTX
CBNumber
CB5345867
Molecular Formula
C7H17Cl2N2O3P
Formula Weight
279.1
MOL File
6055-19-2.mol
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Cyclophosphamide monohydrate Property

Melting point:
49-51 °C (lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
H2O: 0.1 g/mL, clear, colorless
form 
Crystals or Crystalline Powder
color 
White to almost white
Water Solubility 
40 g/L
Merck 
14,2747
BRN 
8167897
Stability:
Hygroscopic
InChIKey
PWOQRKCAHTVFLB-UHFFFAOYSA-N
CAS DataBase Reference
6055-19-2(CAS DataBase Reference)
IARC
1 (Vol. 26, Sup 7, 100A) 2012
EPA Substance Registry System
Cyclophosphamide monohydrate (6055-19-2)
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Safety

Hazard Codes 
T
Risk Statements 
45-25-61-46-36/37/38-23/24/25
Safety Statements 
53-45-37/39-26
RIDADR 
UN 3464 6.1/PG 3
WGK Germany 
3
RTECS 
RP6157750
F 
10
HazardClass 
6.1
PackingGroup 
II
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H340May cause genetic defects

H350May cause cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
93813
Product name
Cyclophosphamide monohydrate
Purity
analytical standard
Packaging
100mg
Price
$69.5
Updated
2024/03/01
Sigma-Aldrich
Product number
239785
Product name
CyclophosphamideMonohydrate-CAS6055-19-2-Calbiochem
Purity
Awidelyusedanti-neoplasticagentthatalsodisplaysimmunosuppressantpropert
Packaging
1g
Price
$111
Updated
2024/03/01
TCI Chemical
Product number
C2236
Product name
Cyclophosphamide Monohydrate
Purity
>98.0%(N)
Packaging
5g
Price
$114
Updated
2024/03/01
TCI Chemical
Product number
C2236
Product name
Cyclophosphamide Monohydrate
Purity
>98.0%(N)
Packaging
25g
Price
$385
Updated
2024/03/01
Cayman Chemical
Product number
13849
Product name
Cyclophosphamide (hydrate)
Purity
≥98%
Packaging
1g
Price
$32
Updated
2024/03/01
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Cyclophosphamide monohydrate Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.

Uses

antineoplastic, alkylating agent

Uses

An immunosuppressive, cytotoxic apoptosis inducer.

Uses

Cyclophosphamide monohydrate is used to treat cancers, autoimmune disorders and AL amyloidosis. It is a nitrogen mustard alkylating agent and reacts with deoxyribonucleic acid (DNA) to get its alkylated derivative. It is also involved in cancer research as a tool that induces apoptosis in tumor cells.

Uses

alkylating agent in cancer therapy

Definition

ChEBI: The monohydrate of cyclophosphamide.

brand name

Cytoxan (Bristol-Myers Squibb); Neosar (Sicor).

General Description

Fine white crystalline powder with a slightly bitter taste. Little or no odor.

Air & Water Reactions

Water soluble. Sensitive to moisture and light. Aqueous solutions may be kept for a few hours above room temperature, but hydrolysis occurs at temperatures above 86°F. Cyclophosphamide monohydrate undergoes both specific acid and specific base catalysis at extreme pHs. Spontaneous hydrolysis in aqueous solutions.

Reactivity Profile

Polymerization can occur at temperatures > 120° F. Cyclophosphamide monohydrate reacts with strong oxidizing agents, strong acids and strong bases. Benzyl alcohol increases rate of hydrolysis.

Fire Hazard

Cyclophosphamide monohydrate is probably combustible.

Biochem/physiol Actions

Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.

Safety Profile

Confirmed human carcinogen. Poison by ingestion and intravenous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl-, PO,, and NOx.

Cyclophosphamide monohydrate Preparation Products And Raw materials

Raw materials

Diethanolamine

Preparation Products

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Cyclophosphamide monohydrate Suppliers

Americas 1 Belgium 2 Canada 1 China 344 Europe 3 France 1 Germany 4 India 21 Japan 4 Poland 1 Russia 1 Switzerland 3 United Kingdom 13 United States 50 Global 449
TCI Chemicals (India) Pvt. Ltd.
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Myosynth Laboratories Private Limited
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Apothecon Pharmaceuticals Pvt., Ltd.
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Chaturya Biotech (Tanuj Life Sciences)
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Rivashaa Agrotech Biopharma Pvt. Ltd.
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Omcham Labs
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Pharmaffiliates Analytics and Synthetics P. Ltd
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SynZeal Research Pvt Ltd
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MSN LABORATORIES PRIVATE LTD
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HETERO LABS LTD
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View Lastest Price from Cyclophosphamide monohydrate manufacturers

HebeiShuoshengImportandExportco.,Ltd
Product
Cyclophosphamide monohydrate 6055-19-2
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-07
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Cyclophosphamide monohydrate 6055-19-2
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
97%-103%; USP
Supply Ability
500kgs
Release date
2021-07-14
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Cyclophosphamide Monohydrate 6055-19-2
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
50kg/Month
Release date
2024-09-05

6055-19-2, Cyclophosphamide monohydrateRelated Search:

MELIBIOSE NITRIC OXIDE Polyamide Rink Amide Linker BUTYL OLEATE Dibenzylamine Tris(trimethylsilyl)phosphate Methyl acrylate Bis(2-ethylhexyl)amine Triallylamine Ethylcyclohexane Fomesafen (Diethoxymethyl)diphenylphosphine oxide Ifosfamide Cyclophosphamide Mafosfamide 4-HYDROPEROXY CYCLOPHOSPHAMIDE IFOSFAMIDE IMPURITY F

  • 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE
  • 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE HYDRATE
  • 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE MONOHYDRATE
  • CPA
  • ENDOXON
  • CYTOXAN
  • CYCLOPHOSPHAMIDE HYDRATE
  • CYCLOPHOSPHAMIDE MONOHYDRATE
  • CYCLOPHOSPHAMID MONOHYDRATE
  • bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate
  • N,N-BIS(2-CHLOROETHYL)TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORIN-2-AMINE-2-OXIDE MONOHYDRATE
  • n,n-bis(beta-chloroethyl)-n',o-propylenephosphoric acid ester amide monohydrate
  • TIMTEC-BB SBB003026
  • > 100 Kgyclophosphamide monohydrate
  • Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester~Cyclophosphane
  • cyclophosphamide isopac
  • Cyclophosphamide sterile
  • Cyclophos phamide USP
  • CYCLOPHOSPHAMIDE MONOHYDRATE, 98+%
  • CyclophosphamideSterile,Usp28
  • Cyclophosphamidemonohaydrate
  • Cyclophosphamide monohydrate, 97%, a nitrogen mustard alkylating agent
  • CYCLOPHOSPHAMIDE 1-HYDRATE
  • 2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide, monohydrate
  • CyclophosphaMide,awater
  • 2-(Bis(2-chloroethyl)aMino)-1,3,2-oxazaphosphinane 2-oxide hydrate
  • 2-oxide-N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine, hydrate (1:1)
  • Bis(2-chloroethyl)phosphoramide cyclic propanolamide este
  • Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester m
  • (bis(chloro-2-ethyl)amino)-2-tetrahydro-3,4,5,6-oxazaphosphorine-1,3,2-oxide
  • 1-bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridinemonohydrate
  • 2-(bis(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphocyclohexane2-oxidemonohydr
  • 2-(di(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphacyclohexane-2-oxidemonohydra
  • 2h-1,3,2-oxazaphosphorine,tetrahydro-2-(bis(2-chloroethyl)amino)-,2-oxide,mo
  • -2monohydrate
  • cyclicn’,o-propyleneesterofn,n-bis(2-chloroethyl)phosphorodiamidicacidm
  • endoxanmonohydrate
  • n,n-bis(2-chloroethyl)tetrahydro-2h-1,3,2-oxaphosphorin-2-amine,2-oxidemono
  • N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphos-phorin-2-amine2-oxide
  • n,n-bis(beta-chloroethyl)-n’,o-propylenephosphoricacidesteramidemonohydra
  • n,n-bis(beta-chloroethyl)-n’,o-trimethylenephosphoricacidesterdiamidemono
  • Procy-tox
  • n,n-bis(beta-cloraethyl)n’-o-propylenphosphorildiamidmonohydratum
  • N,N-Bis-2-chloroethyl-N’,O-propylenephosphoricesterdiamidemonohydrate
  • n,n-di(2-chloroethyl)amino-n,o-propylenephosphoricacidesterdiamidemonohy
  • CYCLOPHOPHAMIDEMONOHYDRATE
  • CYCLOPHOSPHAMIDE,MONOHYDRATE,USP
  • CYCLOPHOSPHAMIDE(HYDRATED)
  • cyclophosphamide，CTX
  • 2h-1,3,2-oxazaphosphorine, tetrahydro-2-(bis(2-chloroethyl)amino)-, 2-oxide, mo (bis(chloro-2-ethyl)amino)-2-tetrahydro-3,4,5,6-oxazaphosphorine-1,3,2-o xide 1-bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridine monohydrate 2-(bis(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphocyclohexane 2-oxide monohydr 2-(di(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphacyclohexane-2-oxide monohydra cyclophosphamide hydrate cyclophosphamide monohydrate endoxan monohydrate
  • Cycloblastin
  • Cyclophosphamide monohydrate, 97+%
  • Cytoxan, 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
  • 2H-1,3,2-Oxazaphosphorine, tetrahydro-2-(bis(2-chloroethyl)amino)-, 2-oxide, monohydrate
  • N,N-Bis(2-chloroethyl)-2-oxo-1-oxa-3-aza-2$l^{5}-phosphacyclohexan-2-amine hydrate
  • CyclophosphamideUsp27
  • Cyclophosphamide monohydrate,2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan
  • Cyclophosphamide (500 mg) (FOR U.S. SALE ONLY)