ChemicalBook > CAS DataBase List > Metoprine

Metoprine

Product Name
Metoprine
CAS No.
7761-45-7
Chemical Name
Metoprine
Synonyms
DDMP;U-197;BW 197U;SK 5265;NSC 7364;NSC-19494;BW-50-197;Metoprine;methodichlorophen;Metoprine, 10 mM in DMSO
CBNumber
CB31179180
Molecular Formula
C11H10Cl2N4
Formula Weight
269.13
MOL File
7761-45-7.mol
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Metoprine Property

Melting point:
275-276℃
Boiling point:
418.42°C (rough estimate)
Density 
1.447
refractive index 
1.6300 (estimate)
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
solubility 
DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated)
form 
Solid
pka
6.80±0.10(Predicted)
color 
Off-White to Light Yellow
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
M338835
Product name
Metoprine
Packaging
25mg
Price
$185
Updated
2021/12/16
Usbiological
Product number
017618
Product name
Metoprine
Packaging
25mg
Price
$460
Updated
2021/12/16
ChemScene
Product number
CS-0105542
Product name
Metoprine
Purity
99.04%
Packaging
100mg
Price
$480
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009149
Product name
METOPRINE
Purity
95.00%
Packaging
25MG
Price
$750.75
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009149
Product name
METOPRINE
Purity
95.00%
Packaging
250MG
Price
$1963.5
Updated
2021/12/16
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Metoprine Chemical Properties,Usage,Production

Uses

A 2,4-Diaminopyrimidine derivative as antimalarial agent.

in vivo

Metoprine (BW 197U; 2-10 mg/kg; IP) ameliorates the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner[2].
Intraperitoneal administration of Metoprine produces various behavioral effects, including decreases in food intake and increases in water consumption[1].

Animal Model:Male Sprague-dawley rats (200-280g)[2]
Dosage:2, 5, 10 mg/kg
Administration:IP
Result:Ameliorated the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner and significanty prolonged transfer latency at a high dose of 10 mg/kg.

Metoprine Preparation Products And Raw materials

Raw materials

Preparation Products

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7761-45-7, MetoprineRelated Search:

5-(4-CHLOROPHENYL)PYRIMIDIN-4-AMINE Etoprine Metoprine

  • 5-(3,4-dichlorophenyl)-6-MethylpyriMidine-2,4-diaMine
  • 5-(3,4-Dichlorophenyl)-6-Methyl-2,4-pyriMidinediaMine
  • BW 197U
  • NSC 7364
  • SK 5265
  • Metoprine
  • methodichlorophen
  • 2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)-6-METHYLPYRIMIDINE
  • BW-50-197
  • DDMP
  • NSC-19494
  • U-197
  • Inhibitor,histamine,HMT,Antifolate,barrier,Metoprine,Histone Methyltransferase,antitumor,N-methyltransferase,diaminopyrimidine,inhibit,BW 197U,blood-brain
  • 2,4-Pyrimidinediamine, 5-(3,4-dichlorophenyl)-6-methyl-
  • Metoprine, 10 mM in DMSO
  • 7761-45-7
  • Bases & Related Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals