Toxicity Description
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ACONINE

Toxicity Description
Product Name
ACONINE
CAS No.
509-20-6
Chemical Name
ACONINE
Synonyms
ACONINE;Aconitysat;Jesaconine;ACONINE USP/EP/BP;Aconine (Jesaconine);20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13...;20-Ethyl-1α,6α,16β-trimethoxy-4-(methoxymethyl)aconitane-3α,8,13,14α,15α-pentol;(15S,16S)-20-Ethyl-1α,6α,16-trimethoxy-4-(methoxymethyl)aconitane-3α,8β,13β,14α,15-pentol;Aconitane-3,8,13,14,15-pentol,20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, (1a,3a,6a,14a,15a,16b)-;Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, (1α,3α,6α,14α,15α,16β)-
CBNumber
CB31229467
Molecular Formula
C25H41NO9
Formula Weight
499.6
MOL File
509-20-6.mol
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ACONINE Property

Melting point:
129-131℃
alpha 
D +23°
Boiling point:
590.79°C (rough estimate)
Density 
1.42
refractive index 
1.6000 (estimate)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), DMSO (Slightly)
pka
9.52(at 25℃)
form 
Solid
color 
Off-White to Pale Yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25048
Product name
Aconine
Purity
≥95%
Packaging
1mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
25048
Product name
Aconine
Purity
≥95%
Packaging
5mg
Price
$214
Updated
2024/03/01
Cayman Chemical
Product number
25048
Product name
Aconine
Purity
≥95%
Packaging
10mg
Price
$350
Updated
2024/03/01
TRC
Product number
A190245
Product name
Aconine
Packaging
1mg
Price
$95
Updated
2021/12/16
Usbiological
Product number
299879
Product name
Aconine
Packaging
10mg
Price
$490
Updated
2021/12/16
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ACONINE Chemical Properties,Usage,Production

Toxicity

In vivo, aconine is toxic to mice when administered intravenously at a dose of 120 mg/kg. It induces flaccid paralysis and toxicity in rats with toxic dose (TD50) and LD50 values of 1.5 and 1.7 μmol per animal, respectively.

Description

Aconine is an alkaloid originally isolated from Aconitum species and active metabolite of aconitine. It inhibits osteoclast differentiation of RANKL-stimulated RAW 264.7 cells and bone resorption in a pit formation assay in a concentration-dependent manner. Aconine also inhibits RANKL-induced activation of NF-κB and NFATc1 in RAW 264.7 cells.

Description

Aconine is an alkaloid originally isolated from Aconitum species and active metabolite of aconitine. It inhibits osteoclast differentiation of RANKL-stimulated RAW 264.7 cells and bone resorption in a pit formation assay in a concentration-dependent manner. Aconine also inhibits RANKL-induced activation of NF-κB and NFATc1 in RAW 264.7 cells. In vivo, aconine is toxic to mice when administered intravenously at a dose of 120 mg/kg. It induces flaccid paralysis and toxicity in rats with toxic dose (TD50) and LD50 values of 1.5 and 1.7 μmol per animal, respectively.

Uses

Aconine is a derivative of Aconitine (A189875), a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction.

Definition

ChEBI: Aconine is a diterpene alkaloid with formula C25H41NO9 that is isolated from several Aconitum species. It has a role as a plant metabolite, a human urinary metabolite, a NF-kappaB inhibitor and a xenobiotic. It is a bridged compound, a diterpene alkaloid, an organic heteropolycyclic compound, a polyether, a tertiary amino compound, a pentol, a secondary alcohol and a tertiary alcohol. It derives from a hydride of an aconitane.

ACONINE Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from ACONINE manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
Aconine 509-20-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-24
Career Henan Chemical Co
Product
ACONINE 509-20-6
Price
US $1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-24

509-20-6, ACONINERelated Search:


  • ACONINE
  • (15S,16S)-20-Ethyl-1α,6α,16-trimethoxy-4-(methoxymethyl)aconitane-3α,8β,13β,14α,15-pentol
  • 20-Ethyl-1α,6α,16β-trimethoxy-4-(methoxymethyl)aconitane-3α,8,13,14α,15α-pentol
  • (1alpha,3alpha,6alpha,14alpha,15alpha,16beta)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol
  • Jesaconine
  • Aconitane-3,8,13,14,15-pentol,20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, (1a,3a,6a,14a,15a,16b)-
  • Aconine (Jesaconine)
  • Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, (1α,3α,6α,14α,15α,16β)-
  • ACONINE USP/EP/BP
  • 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13...
  • Aconitysat
  • 509-20-6
  • C25H41NO9
  • Alkaloids
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract