7-Chlorothieno[3,2-b]pyridine
- Product Name
- 7-Chlorothieno[3,2-b]pyridine
- CAS No.
- 69627-03-8
- Chemical Name
- 7-Chlorothieno[3,2-b]pyridine
- Synonyms
- 7-chlorothieno[3;7-Chlorothieno[3,2-b]pyri...;7-Chlorothieno[3,2-b]pyridine;Thieno[3,2-b]pyridine, 7-chloro-;7-Chlorothieno[3,2-b]pyridine 98%;7-Chlorothieno[3,2-B] pyridine, 98%min
- CBNumber
- CB31235200
- Molecular Formula
- C7H4ClNS
- Formula Weight
- 169.63
- MOL File
- 69627-03-8.mol
7-Chlorothieno[3,2-b]pyridine Property
- Melting point:
- 34.0-35.5 °C
- Boiling point:
- 257.5±20.0 °C(Predicted)
- Density
- 1.435±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- powder to lump
- pka
- 2.87±0.30(Predicted)
- color
- White to Yellow to Orange
- InChI
- InChI=1S/C7H4ClNS/c8-5-1-3-9-6-2-4-10-7(5)6/h1-4H
- InChIKey
- GYQUXKQLCNFKQT-UHFFFAOYSA-N
- SMILES
- C12C=CSC1=C(Cl)C=CN=2
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- C3541
- Product name
- 7-Chlorothieno[3,2-b]pyridine
- Packaging
- 1G
- Price
- $85
- Updated
- 2025/07/31
- Product number
- C3541
- Product name
- 7-Chlorothieno[3,2-b]pyridine
- Packaging
- 5G
- Price
- $300
- Updated
- 2025/07/31
- Product number
- C351375
- Product name
- 7-Chlorothieno[3,2-b]pyridine
- Packaging
- 5g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FC53344
- Product name
- 7-Chlorothieno[3,2-B]Pyridine
- Packaging
- 5G
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 7H70-5-19
- Product name
- 7-Chlorothieno[3,2-b]pyridine
- Packaging
- 5G
- Price
- $150
- Updated
- 2021/12/16
7-Chlorothieno[3,2-b]pyridine Chemical Properties,Usage,Production
Uses
7-Chlorothieno[3,2-b]pyridine is a pyridine derivative and a pharmaceutical intermediate compound. It can be used in the preparation of piperidines and deuterated thiophene pyridine compounds, and can also be used in the synthesis of compounds with anticancer activity.
Chemical Properties
7-Chlorothieno[3,2-b]pyridine is a white to yellow to orange powder to lumpy intermediate composition. It has a melting point of 35 °C and a flash point of 110 °C. It is stored at 0-10 °C. It is irritating to eyes and skin.
Synthesis
69627-02-7
69627-03-8
To a 250 mL round-bottomed flask were added 30 mL of methylene chloride and 20 mL of ethylene chloride, followed by N,N-dimethylformamide (1.8 mL, 23.28 mmol) and oxalyl chloride (2.9 mL, 33.86 mmol). Oxalyl chloride was slowly added dropwise to the mixture at 0 °C. Next, thieno[3,2-b]pyridin-7(4H)-one (1.6 g, 10.58 mmol) was added and the reaction mixture was heated to reflux for 6 hours. After completion of the reaction, the mixture was cooled to room temperature to afford 7-chlorothieno[3,2-b]pyridine (1.7 g, 90% yield) as a pale yellow solid. The product was characterized by 1H-NMR (400 MHz, CDCl3): δ 8.61 (d, J = 5.2 Hz, 1H), 7.81 (d, J = 5.2 Hz, 1H), 7.30 (d, J = 4.8 Hz, 1H).
References
[1] Patent: US2013/72482, 2013, A1. Location in patent: Paragraph 0281; 0286; 0287
[2] Patent: EP1724268, 2006, A1. Location in patent: Page/Page column 50-51
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 1, p. 21 - 24
[4] Patent: CN107151240, 2017, A. Location in patent: Paragraph 0262; 0263; 0264
[5] Journal of Chemical Research, Miniprint, 1984, # 3, p. 771 - 795
7-Chlorothieno[3,2-b]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-Chlorothieno[3,2-b]pyridine manufacturers
- Product
- 7-Chlorothieno[3,2-b]pyridine 69627-03-8
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-27
- Product
- 7-Chlorothieno[3,2-b]pyridine 69627-03-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500kg
- Release date
- 2018-08-19