ISOPROPAMIDE IODIDE

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ISOPROPAMIDE IODIDE

Product Name: ISOPROPAMIDE IODIDE
CAS No.: 71-81-8
Chemical Name: ISOPROPAMIDE IODIDE
Synonyms: r79;isamid;darbid;5579md;skf4740;dipramid;priamide;sanulcin;Tyrimide;dipramide
CBNumber: CB3123931
Molecular Formula: C23H33IN2O
Formula Weight: 480.43
MOL File: 71-81-8.mol

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ISOPROPAMIDE IODIDE Property

Melting point:: 199℃ (Decomposition)
Density: 1.2711 (estimate)
storage temp.: Store at -20°C
solubility: DMSO: 250 mg/mL (520.37 mM)
Water Solubility: Practically insoluble in water
form: powder to crystal
color: White to Almost white
Merck: 14,5202

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 2
RTECS: BP0693200
HS Code: 2924296000
Toxicity: LD50 oral in rat: > 10gm/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1350002
Product name: Isopropamide iodide
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $358
Updated: 2024/03/01

TCI Chemical

Product number: I1048
Product name: Isopropamide Iodide
Purity: >95.0%(HPLC)(T)
Packaging: 1g
Price: $33
Updated: 2024/03/01

TCI Chemical

Product number: I1048
Product name: Isopropamide Iodide
Purity: >95.0%(HPLC)(T)
Packaging: 5g
Price: $101
Updated: 2024/03/01

TRC

Product number: I822775
Product name: Isopropamide iodide
Packaging: 25mg
Price: $210
Updated: 2021/12/16

Chem-Impex

Product number: 37978
Product name: Isopropamideiodide,95%(HPLC)
Purity: 95%(HPLC)
Packaging: 1G
Price: $221.76
Updated: 2021/12/16

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ISOPROPAMIDE IODIDE Chemical Properties,Usage,Production

Originator

Darbid,SKF,US,1957

Uses

Isopropamide Iodide acts as an anticholinergic compound with inhibitory activity. Also acts as a muscarinic receptor antagonist which can be applied to treatment of diseases affecting cognition including Alzheimer’s disease.

Uses

Isopropamide inhibits muscarinic action of acetylcholine on postganglionic parasympathetic effector regions. It is used for treating stomach ulcers and inflamed intestine.

Definition

ChEBI: Isopropamide iodide is a diarylmethane.

Manufacturing Process

γ-Diisopropylamino-α,α-diphenylbutyronitrile (60 g) was added in several portions to a mixture of sulfuric acid (150 ml) and water (15 ml) and the solution was heated 3% hours on the steam bath and then poured on ice and made basic with NH4OH. The γ-diisopropylamino-α,α-diphenylbutyramide precipitated as a solid, which was taken up in methylene chloride from an aqueous slurry. The methylene chloride was separated and dried by filtering through anhydrous K2CO3. The solvent was removed by distillation, leaving the amide which was crystallized from Skellysolve B five times and found then to have MP 87.0° to 88.5°C.
γ-Diisopropylamino-α,α-diphenylbutyramide in propanol was refluxed 4 hours in the presence of excess methyl iodide. Upon dilution of the solution with ethyl acetate (100 ml per 50 ml isopropyl alcohol) and cooling γ- diisopropylamino-α,α-diphenylbutyramide methiodide precipitated, was collected by filtration and recrystallized (9.0 g) by dissolving in a hot mixtureof 100 ml isopropyl alcohol and 10 ml methanol and then diluting with 90 ml Skellysolve B, to give 8.3 g recrystallized product, MP 182° to 184°C.

brand name

Darbid (GlaxoSmithKline).

Therapeutic Function

Spasmolytic

General Description

Isopropamide iodide, 3-carbamoyl-3,3-diphenylpropyl)diisopropylmethylammoniumiodide (Darbid), occurs as a bitter, white to pale yellow, crystallinepowder that is only sparingly soluble in water butfreely soluble in chloroform and alcohol.
This drug, introduced in 1957, is a potent anticholinergic,producing atropine-like effects peripherally. Even with itsquaternary nature, it does not cause sympathetic blockade atthe ganglionic level except at high dosages. Its principal distinguishingfeature is its long duration of action. A singledose can provide antispasmodic and antisecretory effects foras long as 12 hours.

Clinical Use

ISOPROPAMIDE IODIDE is used as adjunctive therapy in the treatment of pepticulcer and other conditions of the GI tract associated withhypermotility and hyperacidity. It has the usual side effectsof anticholinergics (dryness of mouth, mydriasis, difficulturination) and is contraindicated in glaucoma, prostatic hypertrophy,etc.

Synthesis

Isopropamide, (3-carbamoyl-3,3-diphenylpropyl)di-iso-propylmethyl ammonium iodide (14.1.25), is synthesized by alkylating diphenylacetonitrile with di-isopropylaminoethylchloride in the presence of sodium amide, and the subsequent hydrolysis of the nitrile group of the resulting compound (14.1.23) to an amide group (14.1.24). Alkylation of this compound with methyliodide gives isopropamide (14.1.25) [19¨C22].

ISOPROPAMIDE IODIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ISOPROPAMIDE IODIDE Suppliers

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View Lastest Price from ISOPROPAMIDE IODIDE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: IsopropaMide Iodide 71-81-8
Price: US $0.00/g
Min. Order: 1g
Purity: 98.0%
Supply Ability: 1kg/month
Release date: 2021-12-16

Shaanxi Dideu Medichem Co. Ltd

Product: ISOPROPAMIDE IODIDE 71-81-8
Price: US $0.10/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10
Release date: 2024-08-04

71-81-8, ISOPROPAMIDE IODIDERelated Search:

(S)-Metolachlor Propisochlor DL-Mandelic acid Decanedihydrazide 1,2-Ethanedithiol diisopromine (R)-(+)-1-(1-Naphthyl)ethylamine ISOPROPAMIDE IODIDE 3,3-Diphenylpropylamine 2,2-DIPHENYLACETAMIDE N-Methyl-3,3-diphenylpropylamine 4-(diisopropylamino)-2,2-diphenylbutyramide alpha-Methylhydratropamide (R)-2-PHENYLPROPYLAMIDE N,N,3,3-Tetramethylbutylamine, 99% Isopropamide iodide USP23 AMMONIUM, TRIMETHYL(3-PHENYLPROPYL)-, IODIDE

LABOTEST-BB LT00772055

ISOPROPAMIDE

ISOPROPAMIDE IODIDE

(3-carbamoyl-3,3-diphenylpropyl)diisopropylmethyl-ammoniuiodide

(3-carbamoyl-3,3-diphenylpropyl)diisopropylmethylammoniumiodide

2,2-diphenyl-4-diisopropylaminobutyramidemethiodide

5579md

darbid

dipramid

dipramide

isamid

marygin-m

piaccamide

priamide

priazimide

r79

sanulcin

skf4740

Tyrimide

Isopropamide Iodide (200 mg)

Benzenepropanaminium, .gamma.-(aminocarbonyl)-N-methyl-N,N-bis(1-methylethyl)-.gamma.-phenyl-, iodide

ISOPROPAMIDEIODIDE,USP

(4-amino-4-oxo-3,3-diphenylbutyl)-methyl-di(propan-2-yl)azanium:iodide

4-Amino-N,N-diisopropyl-N-methyl-4-oxo-3,3-diphenyl-1-butanaminium Iodide

Isopropamide Iodide (1350002)

RSYYIsopropamide Iodide

Inhibitor,peptic,inhibit,anticholinergic,long-acting,ulcer,hyperacidity,Isopropamide Iodide,gastrointestinal,hypermotility,Isopropamide

Benzenepropanaminium,g-(aminocarbonyl)-N-methyl-N,N-bis(1-methylethyl)-g-phenyl-,iodide(1:1)

71-81-8

C23H33IN2O

C23H33N2OI

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Analytical Standards

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DARBID