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AMD 3465 (*Hexahydrobromide*)

Product Name
AMD 3465 (*Hexahydrobromide*)
CAS No.
185991-07-5
Chemical Name
AMD 3465 (*Hexahydrobromide*)
Synonyms
CS-810;AMD 3465;AMD3465,98%;GENZ-644494;AMD 3465 (hydrobroMide);AMD3465;AMD-3465;AMD 3465;AMD 3465 (*Hexahydrobromide*);AMD3465 R10406hexahydrobromide;AMD 3465 hexahydrobromide, 10 mM in DMSO;AMD 3465 hexahydrobromide, CXCR4 antagonist
CBNumber
CB31244963
Molecular Formula
C24H39BrN6
Formula Weight
491.52
MOL File
185991-07-5.mol
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AMD 3465 (*Hexahydrobromide*) Property

Melting point:
>200°C (dec.)
storage temp. 
-20°C
solubility 
DMSO (Slightly), Methanol (Very Slightly), Water (Slightly)
form 
powder
color 
white to light brown
Water Solubility 
H2O: 25mg/mL, clear
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1433
Product name
AMD3465
Purity
≥98% (HPLC)
Packaging
5MG
Price
$146
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1433
Product name
AMD3465
Purity
≥98% (HPLC)
Packaging
25MG
Price
$577
Updated
2025/07/31
Cayman Chemical
Product number
11959
Product name
AMD 3465 (hydrobromide)
Purity
≥95%
Packaging
5mg
Price
$96
Updated
2024/03/01
Cayman Chemical
Product number
11959
Product name
AMD 3465 (hydrobromide)
Purity
≥95%
Packaging
10mg
Price
$182
Updated
2024/03/01
Cayman Chemical
Product number
11959
Product name
AMD 3465 (hydrobromide)
Purity
≥95%
Packaging
25mg
Price
$403
Updated
2024/03/01
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AMD 3465 (*Hexahydrobromide*) Chemical Properties,Usage,Production

Uses

AMD 3465 is a CXCR4 antagonist and in combination with monoclonal antibody, was shown to be potentially effective in reducing tumor growth and increasing survival in patient with B cell lymphoma

Biochem/physiol Actions

AMD3465 is also termed as{N-[1,4,8,11-tetraazacyclotetradecanyl-1,4-phenylenebis(methylene)]-2-(aminomethyl)pyridine}. It controls oncogenic signaling and invasiveness in vitro. It inhibits breast cancer growth and metastasis in vivo. As a chemokine receptor 4 (CXCR4) antagonist, AMD3465 is ten times more efficient than bicyclam AMD3100.

in vivo

AMD 3465 (2.5 mg/kg/d, s.c. for 5 weeks) significantly blocks the growth of U87 GBM and Daoy xenografts[2].

IC 50

12G5 mAb-CXCR4: 0.75 nM (IC50, in SupT1 cells); CXCL12AF647-CXCR4: 18 nM (IC50, in SupT1 cells); X4 HIV-1 (NL4.3): 6.1 nM (IC50, in MT-4 cells); X4 HIV-1 (RF): 7.4 nM (IC50, in MT-4 cells); X4 HIV-1 (HE): 9.8 nM (IC50, in MT-4 cells); X4 HIV-1 (IIIB): 12.3 nM (IC50, in MT-4 cells); X4 HIV-1 (NL4.3AMD3100): 2822 nM (IC50, in MT-4 cells); HIV-2 (ROD): 12.3 nM (IC50, in MT-4 cells); HIV-2 (EHO): 12.3 nM (IC50, in MT-4 cells)

storage

Store at -20°C

AMD 3465 (*Hexahydrobromide*) Preparation Products And Raw materials

Raw materials

Preparation Products

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AMD 3465 (*Hexahydrobromide*) Suppliers

Canada 1 China 91 United Kingdom 1 United States 19 Global 112
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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96815
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Chemsky（shanghai）International Co.,Ltd.
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021-50135380
Email
shchemsky@sina.com
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China
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Shanghai Sphchem Co., Ltd.
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021-56491756 13512199871
Fax
021-5649-1756
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2819742715@qq.com
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1-631-485-4226; 16314854226
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info@bocsci.com
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
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China
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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info@chemexpress.com
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MedChemexpress LLC
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sales@medchemexpress.cn
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Guangzhou Isun Pharmaceutical Co., Ltd
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020-39119399 18927568969
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020-39119999
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isunpharm@qq.com
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China
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AdooQ BioScience, LLC
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+1 (866) 930-6790
Fax
+1 (866) 333-9607
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info@adooq.com
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Changzhou Renaissance Chem Co. Ltd
Tel
86-519-86202821
Fax
Email： sales@rosewellchem.com
Country
China
ProdList
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View Lastest Price from AMD 3465 (*Hexahydrobromide*) manufacturers

Honest Joy Holdings Limited
Product
AMD3465hexahydrobroMide 185991-07-5
Price
US $0.00/KG
Min. Order
1KG
Purity
97.4%
Supply Ability
100 tons
Release date
2022-01-14
Career Henan Chemical Co
Product
AMD 3465 (*Hexahydrobromide*) 185991-07-5
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000kg
Release date
2020-01-13

185991-07-5, AMD 3465 (*Hexahydrobromide*)Related Search:


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