ChemicalBook > CAS DataBase List > AMD 3465 (*Hexahydrobromide*)

AMD 3465 (*Hexahydrobromide*)

Product Name
AMD 3465 (*Hexahydrobromide*)
CAS No.
185991-07-5
Chemical Name
AMD 3465 (*Hexahydrobromide*)
Synonyms
CS-810;AMD 3465;AMD3465,98%;GENZ-644494;AMD 3465 (hydrobroMide);AMD3465;AMD-3465;AMD 3465;AMD 3465 (*Hexahydrobromide*);AMD3465 R10406hexahydrobromide;AMD 3465 hexahydrobromide, 10 mM in DMSO;AMD 3465 hexahydrobromide, CXCR4 antagonist
CBNumber
CB31244963
Molecular Formula
C24H39BrN6
Formula Weight
491.52
MOL File
185991-07-5.mol
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AMD 3465 (*Hexahydrobromide*) Property

Melting point:
>200°C (dec.)
storage temp. 
-20°C
solubility 
DMSO (Slightly), Methanol (Very Slightly), Water (Slightly)
form 
powder
color 
white to light brown
Water Solubility 
H2O: 25mg/mL, clear
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1433
Product name
AMD3465
Purity
≥98% (HPLC)
Packaging
5MG
Price
$146
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1433
Product name
AMD3465
Purity
≥98% (HPLC)
Packaging
25MG
Price
$577
Updated
2025/07/31
Cayman Chemical
Product number
11959
Product name
AMD 3465 (hydrobromide)
Purity
≥95%
Packaging
5mg
Price
$96
Updated
2024/03/01
Cayman Chemical
Product number
11959
Product name
AMD 3465 (hydrobromide)
Purity
≥95%
Packaging
10mg
Price
$182
Updated
2024/03/01
Cayman Chemical
Product number
11959
Product name
AMD 3465 (hydrobromide)
Purity
≥95%
Packaging
25mg
Price
$403
Updated
2024/03/01
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AMD 3465 (*Hexahydrobromide*) Chemical Properties,Usage,Production

Uses

AMD 3465 is a CXCR4 antagonist and in combination with monoclonal antibody, was shown to be potentially effective in reducing tumor growth and increasing survival in patient with B cell lymphoma

Biochem/physiol Actions

AMD3465 is also termed as{N-[1,4,8,11-tetraazacyclotetradecanyl-1,4-phenylenebis(methylene)]-2-(aminomethyl)pyridine}. It controls oncogenic signaling and invasiveness in vitro. It inhibits breast cancer growth and metastasis in vivo. As a chemokine receptor 4 (CXCR4) antagonist, AMD3465 is ten times more efficient than bicyclam AMD3100.

in vivo

AMD 3465 (2.5 mg/kg/d, s.c. for 5 weeks) significantly blocks the growth of U87 GBM and Daoy xenografts[2].

IC 50

12G5 mAb-CXCR4: 0.75 nM (IC50, in SupT1 cells); CXCL12AF647-CXCR4: 18 nM (IC50, in SupT1 cells); X4 HIV-1 (NL4.3): 6.1 nM (IC50, in MT-4 cells); X4 HIV-1 (RF): 7.4 nM (IC50, in MT-4 cells); X4 HIV-1 (HE): 9.8 nM (IC50, in MT-4 cells); X4 HIV-1 (IIIB): 12.3 nM (IC50, in MT-4 cells); X4 HIV-1 (NL4.3AMD3100): 2822 nM (IC50, in MT-4 cells); HIV-2 (ROD): 12.3 nM (IC50, in MT-4 cells); HIV-2 (EHO): 12.3 nM (IC50, in MT-4 cells)

storage

Store at -20°C

AMD 3465 (*Hexahydrobromide*) Preparation Products And Raw materials

Raw materials

Preparation Products

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AMD 3465 (*Hexahydrobromide*) Suppliers

Canada 1 China 91 United Kingdom 1 United States 19 Global 112
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View Lastest Price from AMD 3465 (*Hexahydrobromide*) manufacturers

Honest Joy Holdings Limited
Product
AMD3465hexahydrobroMide 185991-07-5
Price
US $0.00/KG
Min. Order
1KG
Purity
97.4%
Supply Ability
100 tons
Release date
2022-01-14
Career Henan Chemical Co
Product
AMD 3465 (*Hexahydrobromide*) 185991-07-5
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000kg
Release date
2020-01-13

185991-07-5, AMD 3465 (*Hexahydrobromide*)Related Search:


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  • N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide
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  • AMD 3465 hexahydrobromide, 10 mM in DMSO
  • 185991-07-5
  • C24H38N66HBr
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