4-Bromo-2-fluoro-5-methylaniline
- Product Name
- 4-Bromo-2-fluoro-5-methylaniline
- CAS No.
- 418762-26-2
- Chemical Name
- 4-Bromo-2-fluoro-5-methylaniline
- Synonyms
- 4-Bromo-2-fluoro-5-methylaniline;4-BROMO-2-FLUORO-5-METHYLANILINE 97%;4-Bromo-2-fluoro-5-methylbenzenamine;4-Bromo-2-fluoro-5-methyl-phenylamine;BenzenaMine,4-broMo-2-fluoro-5-Methyl-
- CBNumber
- CB31264035
- Molecular Formula
- C7H7BrFN
- Formula Weight
- 204.04
- MOL File
- 418762-26-2.mol
4-Bromo-2-fluoro-5-methylaniline Property
- Boiling point:
- 229.5±35.0 °C(Predicted)
- Density
- 1.589±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 2.62±0.10(Predicted)
- Appearance
- Off-white to pink Solid
- InChI
- InChI=1S/C7H7BrFN/c1-4-2-7(10)6(9)3-5(4)8/h2-3H,10H2,1H3
- InChIKey
- NBRIVALIHOZFTH-UHFFFAOYSA-N
- SMILES
- C1(N)=CC(C)=C(Br)C=C1F
Safety
- HS Code
- 2921430090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B699423
- Product name
- 4-Bromo-2-fluoro-5-methylaniline
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB34006
- Product name
- 4-Bromo-2-fluoro-5-methylaniline
- Packaging
- 2g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- X4574
- Product name
- 4-Bromo-2-fluoro-5-methylaniline
- Packaging
- 5g
- Price
- $62
- Updated
- 2021/12/16
- Product number
- FB34006
- Product name
- 4-Bromo-2-fluoro-5-methylaniline
- Packaging
- 5G
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB34006
- Product name
- 4-Bromo-2-fluoro-5-methylaniline
- Packaging
- 10g
- Price
- $100
- Updated
- 2021/12/16
4-Bromo-2-fluoro-5-methylaniline Chemical Properties,Usage,Production
Synthesis
452-84-6
418762-26-2
General procedure for the synthesis of 4-bromo-2-fluoro-5-methylaniline using 2-fluoro-5-methylaniline as starting material: 2-fluoro-5-methylaniline (6.75 g, 54 mmol) and calcium carbonate (10 g, 100 mmol) were suspended in a solvent mixture of dichloromethane (1 L) and methanol (400 mL). A solution of benzyltrimethylammonium tribromide (22.3 g, 57 mmol) in dichloromethane (180 mL) and methanol (70 mL) was slowly added dropwise with stirring. After the dropwise addition was completed, the reaction mixture was stirred at room temperature overnight and the color of the solution was observed to change to light orange to tan. After completion of the reaction, the insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure to remove the solvent. The concentrated residue was diluted with water (100 mL) and extracted with ether (3 x 200 mL). The organic phases were combined and purified by fast column chromatography (eluent ratio: n-hexane/ether 2:1 tapering to pure ether) to afford the target product 4-bromo-2-fluoro-5-methylaniline (9 g, yield 69.5%) as a white solid. The product was characterized by 1H-NMR (DMSO-d6): δ 7.23 (d, J = 10.8 Hz, 1H), 6.74 (d, J = 10.8 Hz, 1H), 5.27 (s, 2H), 2.20 (s, 3H).
References
[1] Patent: WO2007/64931, 2007, A2. Location in patent: Page/Page column 193-194
[2] Patent: WO2016/60941, 2016, A1. Location in patent: Page/Page column 46; 47
4-Bromo-2-fluoro-5-methylaniline Preparation Products And Raw materials
Raw materials
Preparation Products
4-Bromo-2-fluoro-5-methylaniline Suppliers
- Tel
- --
- Fax
- --
- sales@labotest.com
- Country
- Germany
- ProdList
- 3564
- Advantage
- 42
View Lastest Price from 4-Bromo-2-fluoro-5-methylaniline manufacturers
- Product
- 4-Bromo-2-fluoro-5-methylaniline 418762-26-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 4-Bromo-2-fluoro-5-methylaniline 418762-26-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 4-Bromo-2-fluoro-5-methylaniline 418762-26-2
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-07-30