5-CYANO-2-FLUOROBENZOIC ACID
Application- Product Name
- 5-CYANO-2-FLUOROBENZOIC ACID
- CAS No.
- 146328-87-2
- Chemical Name
- 5-CYANO-2-FLUOROBENZOIC ACID
- Synonyms
- 3-Carboxy-4-fluorobenzonitrile;Benzoic acid,5-cyano-2-fluoro-;5-CYANO-2-FLUOROBENZOIC ACID 5-
- CBNumber
- CB31264116
- Molecular Formula
- C8H4FNO2
- Formula Weight
- 165.12
- MOL File
- 146328-87-2.mol
5-CYANO-2-FLUOROBENZOIC ACID Property
- Melting point:
- 187-189°
- Boiling point:
- 322.1±27.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- Flash point:
- >110°
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.71±0.10(Predicted)
- form
- wooly crystalline powder
- color
- White
Safety
- RIDADR
- UN3439
- HazardClass
- 6.1
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B419958
- Product name
- 5-Cyano-2-fluorobenzoicAcid
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B419958
- Product name
- 5-Cyano-2-fluorobenzoicAcid
- Packaging
- 5g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- FC41907
- Product name
- 5-Cyano-2-fluorobenzoic acid
- Packaging
- 50g
- Price
- $230
- Updated
- 2021/12/16
- Product number
- PC5926
- Product name
- 5-Cyano-2-fluorobenzoicacid
- Packaging
- 25g
- Price
- $104
- Updated
- 2021/12/16
- Product number
- 4637-3-07
- Product name
- 5-Cyano-2-fluorobenzoic acid
- Purity
- 98%
- Packaging
- 25g
- Price
- $120
- Updated
- 2021/12/16
5-CYANO-2-FLUOROBENZOIC ACID Chemical Properties,Usage,Production
Application
5-Cyano-2-fluorobenzoic acid, as a benzoic acid compound with multiple reaction sites and rich chemical reactivity, has broad chemical application prospects in fields such as basic chemical research in organic synthesis and drug development.
Chemical Properties
5-Cyano-2-fluorobenzoic acid contains several reaction sites in its structure and shows good chemical reaction activity, and it can undergo chlorination reaction under the action of dichlorosulfoxide. It can also undergo a condensation reaction with organic amines under the action of a condensation agent, and can be used in the preparation of the corresponding amide derivatives.
Synthesis
337362-21-7
146328-87-2
The general procedure for the synthesis of 2-fluoro-5-cyanobenzoic acid from methyl 5-cyano-2-fluorobenzoate was as follows: to a solution of ethanol (50 mL) containing methyl 5-cyano-2-fluorobenzoate (3.0 g, 16.8 mmol) was added a 40% aqueous solution of KOH (15 mL). The reaction mixture was heated to 45 °C and stirred continuously for 2 h until all solids were completely dissolved. Upon completion of the reaction, the mixture was cooled to room temperature and partially concentrated under reduced pressure. Subsequently, the reaction mixture was diluted with ethyl acetate (EtOAc) and acidified with 10% aqueous hydrochloric acid. The organic and aqueous layers were separated and the aqueous layer was further extracted with ethyl acetate (3 x 20 mL). All organic extracts were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford the target product 2-fluoro-5-cyanobenzoic acid (3.0 g, 16.4 mmol, 98% yield). Mass spectrometry analysis (DCI/NH3) showed m/z 183 (M+NH4)+.
References
[1] Patent: US2010/69348, 2010, A1. Location in patent: Page/Page column 60
[2] Patent: US2010/63022, 2010, A1. Location in patent: Page/Page column 35
[3] Patent: US2011/294780, 2011, A1. Location in patent: Page/Page column 140
5-CYANO-2-FLUOROBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-CYANO-2-FLUOROBENZOIC ACID manufacturers
- Product
- 5-Cyano-2-fluorobenzoic acid 146328-87-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-07
- Product
- 5-CYANO-2-FLUOROBENZOIC ACID 146328-87-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-CYANO-2-FLUOROBENZOIC ACID 146328-87-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09