1H-Indazole-3-carboxamide(6CI,7CI,9CI)
- Product Name
- 1H-Indazole-3-carboxamide(6CI,7CI,9CI)
- CAS No.
- 90004-04-9
- Chemical Name
- 1H-Indazole-3-carboxamide(6CI,7CI,9CI)
- Synonyms
- 1H-indazole-3-carboxaMide;1H-Indazole-3-carboxylic acid aMide;5,6-Difluoro-1H-indazole-3-carboxamide;1H-Indazole-3-carboxamide(6CI,7CI,9CI)
- CBNumber
- CB31272155
- Molecular Formula
- C8H7N3O
- Formula Weight
- 161.16
- MOL File
- 90004-04-9.mol
1H-Indazole-3-carboxamide(6CI,7CI,9CI) Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H225Highly Flammable liquid and vapour
H314Causes severe skin burns and eye damage
H351Suspected of causing cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P235Keep cool.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P363Wash contaminated clothing before reuse.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- I655730
- Product name
- 1H-Indazole-3-carboxamide
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- CHM0003646
- Product name
- INDAZOLYL-3-FORMAMIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $945.95
- Updated
- 2021/12/16
- Product number
- 45R0365
- Product name
- 1H-Indazole-3-carboxylicacidamide
- Purity
- 98%
- Packaging
- 500mg
- Price
- $149
- Updated
- 2021/12/16
- Product number
- O34418
- Product name
- 1H-Indazole-3-carboxamide
- Purity
- 95%
- Packaging
- 5G
- Price
- $385
- Updated
- 2021/12/16
- Product number
- CM150422
- Product name
- 1H-Indazole-3-carboxamide
- Purity
- 98%
- Packaging
- 5g
- Price
- $400
- Updated
- 2021/12/16
1H-Indazole-3-carboxamide(6CI,7CI,9CI) Chemical Properties,Usage,Production
Synthesis
4498-67-3
90004-04-9
General procedure for the synthesis of 1H-indazole-3-carboxamide from indazole-3-carboxylic acid: indazole-3-carboxylic acid (0.3 g, 1.86 mmol) was dissolved in anhydrous THF (7 mL) under nitrogen protection. To this solution, isobutyl chloroformate (0.39 g, 2.94 mmol) and N-methylmorpholine (NMM) (0.297 g, 2.94 mmol) were added sequentially. The reaction mixture was stirred at -20 °C for 2 hours. Subsequently, 5 mL of ammonia solution was added to the reaction system and the mixture was continued to be stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate (5 mL) and subsequently washed with water (2 x 10 mL). The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography with the eluent dichloromethane/methanol (95:5, v/v) to afford the white crystalline product 1H-indazole-3-carboxamide (0.41 g, 85% yield) with a melting point of 284-286 °C. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6, with TMS as internal standard): δ 7.22 (t, 1H, 1H J = 15.00 Hz), 7.32 (s, 1H), 7.40 (t, 1H, J = 14.32 Hz), 7.59 (d, 1H, J = 8.40 Hz), 7.71 (s, 1H), 8.16 (d, 1H, J = 8.16 Hz), 13.51 (s, 1H).
References
[1] Patent: US2012/130078, 2012, A1. Location in patent: Page/Page column 2-3
[2] Chemical Biology and Drug Design, 2012, vol. 79, # 4, p. 488 - 496
[3] Patent: CN103626705, 2016, B. Location in patent: Paragraph 0041; 0042; 0043; 0044
[4] ChemMedChem, 2013, vol. 8, # 5, p. 722 - 725
[5] Patent: WO2017/98328, 2017, A2
1H-Indazole-3-carboxamide(6CI,7CI,9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-Indazole-3-carboxamide(6CI,7CI,9CI) manufacturers
- Product
- 1H-Indazole-3-carboxamide(6CI,7CI,9CI) 90004-04-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1lg; 2kg; 5kg; 10kg; 100kg
- Release date
- 2019-08-31