2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI)

Product Name: 2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI)
CAS No.: 256519-10-5
Chemical Name: 2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI)
Synonyms: 4-fluoro-1,3-dihydrobenzimidazol-2-one;4-Fluoro-1H-benzo[d]imidazol-2(3H)-one;4-Fluoro-1,3-dihydrobenzoiMidazol-2-one;2H-Benzimidazol-2-one, 4-fluoro-1,3-dihydro-;4-Fluoro-2,3-dihydro-1h-1,3-benzodiazol-2-one;4-fluoro-1,3-dihydro-2H-benzo[d]imidazol-2-one;4-fluoro-1,3-dihydro-2H-1,3-benzimidazole-2-one;2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI)
CBNumber: CB31284859
Molecular Formula: C7H5FN2O
Formula Weight: 152.13
MOL File: 256519-10-5.mol

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2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI) Property

Boiling point:: 116.9±19.0 °C(Predicted)
Density: 1.366±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 10.94±0.30(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F600255
Product name: 4-fluoro-1H-benzo[d]imidazol-2(3H)-one
Packaging: 100mg
Price: $265
Updated: 2021/12/16

AK Scientific

Product number: 5307DA
Product name: 4-Fluoro-1H-benzo[d]imidazol-2(3H)-one
Packaging: 250mg
Price: $190
Updated: 2021/12/16

Apolloscientific

Product number: PC909355
Product name: 4-Fluoro-1H-benzo[d]imidazol-2(3H)-one
Purity: 97%
Packaging: 1g
Price: $203
Updated: 2021/12/16

Apolloscientific

Product number: PC909355
Product name: 4-Fluoro-1H-benzo[d]imidazol-2(3H)-one
Purity: 97%
Packaging: 250mg
Price: $81
Updated: 2021/12/16

Ambeed

Product number: A108309
Product name: 4-Fluoro-1H-benzo[d]imidazol-2(3H)-one
Purity: 97%
Packaging: 250mg
Price: $103
Updated: 2021/12/16

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2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI) Chemical Properties,Usage,Production

Synthesis

18645-88-0

530-62-1

256519-10-5

a) 3-Fluorobenzene-1,2-diamine (0.600 g, 4.76 mmol) was dissolved in tetrahydrofuran (THF, 14.82 mL), and 1,1'-carbonyldiimidazole (0.848 g, 5.23 mmol) was added slowly at room temperature. The reaction mixture was stirred overnight at room temperature and then warmed up to 50 °C to continue the reaction for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature, a methanol solution of ammonia (1.5 mL) was added and stirring was continued for 30 minutes. Subsequently, the reaction mixture was diluted with water (40 mL), the resulting brown solid was collected by filtration, washed with water and dried under vacuum to afford 4-fluoro-1H-benzo[d]imidazol-2(3H)-one (0.700 g, 97% yield). The product could be used in subsequent steps without further purification.1H NMR (400 MHz, DMSO-d6) δ 6.81 (2H, ddd), 6.88-6.95 (1H, m), 10.82 (1H, s), 11.08 (1H, s); Mass Spectrum (ES-) m/z: 151.19 [M-H]-.

References

[1] Patent: US2011/306613, 2011, A1. Location in patent: Page/Page column 31
[2] Patent: US8138168, 2012, B1. Location in patent: Page/Page column 481-482

2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI) Suppliers

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256519-10-5, 2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI)Related Search:

4-Fluoro-1,3-dihydrobenzoiMidazol-2-one

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2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI)

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256519-10-5

HALIDE

BENZIMIDAZOLE