2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI)
- Product Name
- 2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI)
- CAS No.
- 256519-10-5
- Chemical Name
- 2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI)
- Synonyms
- 4-fluoro-1,3-dihydrobenzimidazol-2-one;4-Fluoro-1H-benzo[d]imidazol-2(3H)-one;4-Fluoro-1,3-dihydrobenzoiMidazol-2-one;2H-Benzimidazol-2-one, 4-fluoro-1,3-dihydro-;4-Fluoro-2,3-dihydro-1h-1,3-benzodiazol-2-one;4-fluoro-1,3-dihydro-2H-benzo[d]imidazol-2-one;4-fluoro-1,3-dihydro-2H-1,3-benzimidazole-2-one;2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI)
- CBNumber
- CB31284859
- Molecular Formula
- C7H5FN2O
- Formula Weight
- 152.13
- MOL File
- 256519-10-5.mol
2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI) Property
- Boiling point:
- 116.9±19.0 °C(Predicted)
- Density
- 1.366±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 10.94±0.30(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F600255
- Product name
- 4-fluoro-1H-benzo[d]imidazol-2(3H)-one
- Packaging
- 100mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 5307DA
- Product name
- 4-Fluoro-1H-benzo[d]imidazol-2(3H)-one
- Packaging
- 250mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- PC909355
- Product name
- 4-Fluoro-1H-benzo[d]imidazol-2(3H)-one
- Purity
- 97%
- Packaging
- 1g
- Price
- $203
- Updated
- 2021/12/16
- Product number
- PC909355
- Product name
- 4-Fluoro-1H-benzo[d]imidazol-2(3H)-one
- Purity
- 97%
- Packaging
- 250mg
- Price
- $81
- Updated
- 2021/12/16
- Product number
- A108309
- Product name
- 4-Fluoro-1H-benzo[d]imidazol-2(3H)-one
- Purity
- 97%
- Packaging
- 250mg
- Price
- $103
- Updated
- 2021/12/16
2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI) Chemical Properties,Usage,Production
Synthesis
18645-88-0
530-62-1
256519-10-5
a) 3-Fluorobenzene-1,2-diamine (0.600 g, 4.76 mmol) was dissolved in tetrahydrofuran (THF, 14.82 mL), and 1,1'-carbonyldiimidazole (0.848 g, 5.23 mmol) was added slowly at room temperature. The reaction mixture was stirred overnight at room temperature and then warmed up to 50 °C to continue the reaction for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature, a methanol solution of ammonia (1.5 mL) was added and stirring was continued for 30 minutes. Subsequently, the reaction mixture was diluted with water (40 mL), the resulting brown solid was collected by filtration, washed with water and dried under vacuum to afford 4-fluoro-1H-benzo[d]imidazol-2(3H)-one (0.700 g, 97% yield). The product could be used in subsequent steps without further purification.1H NMR (400 MHz, DMSO-d6) δ 6.81 (2H, ddd), 6.88-6.95 (1H, m), 10.82 (1H, s), 11.08 (1H, s); Mass Spectrum (ES-) m/z: 151.19 [M-H]-.
References
[1] Patent: US2011/306613, 2011, A1. Location in patent: Page/Page column 31
[2] Patent: US8138168, 2012, B1. Location in patent: Page/Page column 481-482
2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
2H-Benzimidazol-2-one,4-fluoro-1,3-dihydro-(9CI) Suppliers
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