lenticin

Product Name: lenticin
CAS No.: 487-58-1
Chemical Name: lenticin
Synonyms: lenticin;Lenticine;Hypaforin;L-Hypaphorine;Glyyunnanenine;tryptophan betaine;inhibit,Hypaphorine,Inhibitor,tinctorius,Pisolithus;(S)-3-(1H-Indol-3-yl)-2-(trimethylammonio)propanoate;(2S)-3-(1H-indol-3-yl)-2-(trimethylammonio)propanoate;α-Carboxylato-N,N,N-trimethyl-1H-indole-3-ethan-1-aminium
CBNumber: CB31312000
Molecular Formula: C14H18N2O2
Formula Weight: 246.30492
MOL File: 487-58-1.mol

More

Less

lenticin Property

Melting point:: 255℃ (decomposition)
alpha: D27 +113° (c = 0.52)
storage temp.: -20°C
solubility: DMF: Slightly soluble; DMSO: Slightly soluble; Ethanol: Slightly soluble; PBS (pH 7.2): 5 mg/ml
form: A solid
color: White to off-white
Stability:: Hygroscopic

More

Less

Safety

Hazard Codes: Xn,N
Risk Statements: 22-50
Safety Statements: 61

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TRC

Product number: H998638
Product name: Hypaphorine
Packaging: 1mg
Price: $70
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PXT0002206
Product name: HYPAPHORINE
Purity: 95.00%
Packaging: 1MG
Price: $590
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 74118
Product name: Hypaphorine
Purity: 98%
Packaging: 20mg
Price: $733
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PXT0002206
Product name: HYPAPHORINE
Purity: 95.00%
Packaging: 5MG
Price: $1000
Updated: 2021/12/16

AvaChem

Product number: 4248
Product name: Hypaphorine
Packaging: 100mg
Price: $890
Updated: 2021/12/16

More

Less

lenticin Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.

Uses

Hypaphorine is an indole alkaloid isolated from Caragana korshinskii. Hypaphorine has neurological and glucose-lowering effects. Hypaphorine prevents Lipopolysaccharides (LPS) (HY-D1056)-mediated acute lung injury (ALI) and proinflammatory response via inactivating the p38/JNK signaling pathway by upregulating DUSP1[1][2][3][4].

Definition

ChEBI: An amino acid betaine obtaine by exhaustive methylation of the alpha-amino group of L-tryptophan with concomitant deprotonation of the carboxy group.

in vivo

Hypaphorine (10 mg/kg; i.p.; 2 hours after the LPS injection) relieves LPS induced acute lung injury (ALI) in rats with anti-inflammatory effects^[2].
Hypaphorine (50 mg/kg; i.p.; once) has antihyperglycemic activity^[4].

Animal Model:	Male albino rats of Wistar/Sprague-Dawley strain (8-10 weeks, 160 g) made diabetic by intraperitoneal injection of Streptozotocin (HY-13753)^[4]
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection (i.p.); once
Result:	Showed significant anti-hyperglycemic activity (27.8% at 5 h and 20.4% at 24 h).

Animal Model:	Male Sprague-Dawley rats (200-220 g) treated with LPS^[2]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection (i.p.); 2 hours after the LPS injection
Result:	Alleviated the histological changes in lung tissues induced by LPS, including severe inflammatory cell infiltration, thickened alveolar walls, obvious diffuse edema, narrowed alveolar space, strengthened interstitial congestion, serious pathological damage and higher scores. Reduced BALF cells and neutrophils increased by LPS. Attenuated the wet/dry weight ratio, capillary permeability and d myeloperoxidase (MPO) activity facilitated by LPS.

References

[1] Keller BO, et al. Hypaphorine is present in human milk in association with consumption of legumes. J Agric Food Chem. 2013 Aug 7;61(31):7654-60. DOI:10.1021/jf401758f
[2] Ding YH, et al. Hypaphorine exerts anti-inflammatory effects in sepsis induced acute lung injury via modulating DUSP1/p38/JNK pathway. Kaohsiung J Med Sci. 2021 Oct;37(10):883-893. DOI:10.1002/kjm2.12418
[3] Ditengou FA, et al. Hypaphorine from the ectomycorrhizal fungus Pisolithus tinctorius counteracts activities of indole-3-acetic acid and ethylene but not synthetic auxins in eucalypt seedlings. Mol Plant Microbe Interact. 2000 Feb;13(2):151-8. DOI:10.1094/MPMI.2000.13.2.151
[4] Chand K, et al. Major alkaloidal constituent from Impatiens niamniamensis seeds as antihyperglycemic agent. Med Chem Res 20, 1505–1508 (2011).

lenticin Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

lenticin Suppliers

China 132 United States 9 Global 141

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

Cheng Du Pufeide Biotechnology Co., Ltd.

Tel: 028-82610909 13388174823
Fax: 8171-1798
Email: scglp@glp-china.com
Country: China
ProdList: 1064
Advantage: 58

Chengdu Herbpurify Co.Ltd.

Tel: 2355253622; 18981954830
Fax: 086-28-85377358
Email: 2355253622@qq.com;
Country: China
ProdList: 1103
Advantage: 58

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Shanghai Aspire Biological Technology Co., Ltd.

Tel: 021-61317773
Fax: 021-61486878
Email: sales@aspirebio.com
Country: China
ProdList: 2880
Advantage: 58

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8144
Advantage: 55

ALB Technology Limited

Tel: 702-983-3769
Fax: 702-983-3769
Email: sales@albtechnology.com
Country: United States
ProdList: 2993
Advantage: 55

More

Less

View Lastest Price from lenticin manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Hypaphorine 487-58-1
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-03-20

Career Henan Chemical Co

Product: lenticin 487-58-1
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-09

487-58-1, lenticinRelated Search:

Cevadine veratramine VERATRIDINE 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one Daurinoline L-Hyoscyamine Xanthiazone daurisoline Xanthiside menisdaurin Coryfolin Scutebarbatine A Anise oil

lenticin

N,N,N-Trimethyl-1-carboxylato-2-(1H-indole-3-yl)ethanaminium

α-Carboxylato-N,N,N-trimethyl-1H-indole-3-ethan-1-aminium

tryptophan betaine

(1-Carboxy-2-indol-3-ylethyl)trimethylammonium hydroxide inner salt

Glyyunnanenine

Lenticine

L-Hypaphorine

Hypaforin

(2S)-3-(1H-indol-3-yl)-2-(trimethylammonio)propanoate

1H-Indole-3-ethanaminium,a-carboxy-N,N,N-trimethyl-, innersalt, (aS)-

(S)-3-(1H-Indol-3-yl)-2-(trimethylammonio)propanoate

inhibit,Hypaphorine,Inhibitor,tinctorius,Pisolithus

487-58-1