osthenol

Product Name: osthenol
CAS No.: 484-14-0
Chemical Name: osthenol
Synonyms: NSC 625328;Osthenol, 10 mM in DMSO;7-Hydroxy-8-prenylcoumarin;7-Hydroxy-8-isopentenyl-2H-1-benzopyran-2-one;7-Hydroxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one;7-Hydroxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 7-hydroxy-8-(3-methyl-2-buten-1-yl)-;inhibit,selective,Monoamine Oxidase,MAO,depression,competitive,Osthenol,Inhibitor,coumarin,Ostenol
CBNumber: CB31312338
Molecular Formula: C14H14O3
Formula Weight: 230.26
MOL File: 484-14-0.mol

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osthenol Property

Melting point:: 89-91 °C
Boiling point:: 422.8±45.0 °C(Predicted)
Density: 1.203±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
form: Solid
pka: 8.45±0.20(Predicted)
color: White to yellow
InChI: InChI=1S/C14H14O3/c1-9(2)3-6-11-12(15)7-4-10-5-8-13(16)17-14(10)11/h3-5,7-8,15H,6H2,1-2H3
InChIKey: RAKJVIPCCGXHHS-UHFFFAOYSA-N
SMILES: C1(=O)OC2=C(C/C=C(/C)\C)C(O)=CC=C2C=C1
LogP: 3.342 (est)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0022826
Product name: Osthenol
Purity: 98.91%
Packaging: 1mg
Price: $120
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0001863
Product name: OSTHENOL
Purity: 95.00%
Packaging: 5MG
Price: $499
Updated: 2021/12/16

Arctom

Product number: SY232770
Product name: Damascenone
Purity: ≥98%
Packaging: 10mg
Price: $190.91
Updated: 2021/12/16

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osthenol Chemical Properties,Usage,Production

Chemical Properties

Soluble in methanol, ethanol, DMSO and other organic solvents, derived from Rhizoma et Radix Notopterygii.

Uses

Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 μM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 μM and shows a high selectivity index for hMAO-A versus hMAO-B[1].

Definition

ChEBI: Osthenol is a hydroxycoumarin that is umbelliferone in which the hydrogen at position 8 has been replaced by a prenyl group. It has a role as a plant metabolite and an antifungal agent. It is functionally related to an umbelliferone.

Biological Activity

Ostenol (Ostenol), a preacylated coumarin isolated from the dried roots of Ostonia, is a reversible, selective and competitive inhibitor of human monoamine oxidase-A (hMAO-A) (Ki=0.26 μM) . Oshenol has a potential selective inhibitory effect on recombinant hMAO-A with IC50 of 0.74 μM, showing a high selectivity index for hMAO-A and hMAO-B.

IC 50

hMAO-A: 0.26 μM (Ki); hMAO-A: 0.74 μM (IC₅₀)

References

[1] Baek SC, et al. Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity. Bioorg Med Chem Lett. 2019;29(6):839-843. DOI:10.1016/j.bmcl.2019.01.016
[2] Liao ZC, et al. Zhongguo Zhong Yao Za Zhi. 2017;42(15):2999-3003. DOI:10.19540/j.cnki.cjcmm.20170512.003

osthenol Preparation Products And Raw materials

Raw materials

Preparation Products

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osthenol Suppliers

China 75 United States 4 USA 1 Global 80

ChengDu YiRui Bio-Technology CO., LTD

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Chengdu Biopurify Phytochemicals Ltd.

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NSC 625328

2H-1-Benzopyran-2-one, 7-hydroxy-8-(3-methyl-2-buten-1-yl)-

inhibit,selective,Monoamine Oxidase,MAO,depression,competitive,Osthenol,Inhibitor,coumarin,Ostenol

Osthenol, 10 mM in DMSO

7-Hydroxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one

484-14-0