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3'-azido-2',3'-dideoxy-5-methylcytidine

Product Name
3'-azido-2',3'-dideoxy-5-methylcytidine
CAS No.
87190-79-2
Chemical Name
3'-azido-2',3'-dideoxy-5-methylcytidine
Synonyms
CS-92;Az-Dcme;AzddMeC;Azidodideoxymethylcytidine;3'-azido-2',3'-dideoxy-5-methylcytidine;3’-Azido-2’,3’-dideoxy-5-methyl cytidine, AzddMC;3'-Azido-2',3'-dideoxy-4-deoxo-4-imino-5-methyluridine
CBNumber
CB31324739
Molecular Formula
C10H14N6O3
Formula Weight
266.26
MOL File
87190-79-2.mol
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3'-azido-2',3'-dideoxy-5-methylcytidine Property

storage temp. 
4°C, away from moisture
solubility 
DMSO : 200 mg/mL (751.15 mM; Need ultrasonic)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H228Flammable solid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403Store in a well-ventilated place.

P501Dispose of contents/container to..…

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3'-azido-2',3'-dideoxy-5-methylcytidine Chemical Properties,Usage,Production

Uses

AzddMeC is used as an antiviral agent for treating viral infection.

in vivo

The pharmacokinetics of AzddMeC are characterized following intravenous and oral administration of 60 mg/kg of the compound to male rhesus monkeys. 3'-azido-3'-deoxythymidine (AZT) is a major metabolite of AzddMeC in monkeys. AzddMeC concentrations in serum declined rapidly in a biexponential fashion with the terminal half-life ranging from 0.5 to 1.3 hr. Renal excretion of unchanged nucleoside and metabolic deamination yielding AZT are the primary routes of AzddMeC clearance. The oral bioavailability is 26%[2].

IC 50

HIV-2; HIV-1: 9 nM (EC50, Human PBM cells); HIV-1: 6 nM (EC50, Human macrophages)

3'-azido-2',3'-dideoxy-5-methylcytidine Preparation Products And Raw materials

Raw materials

Preparation Products

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3'-azido-2',3'-dideoxy-5-methylcytidine Suppliers

China 16 United States 4 Global 20
BOC Sciences
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TargetMol Chemicals Inc.
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87190-79-2, 3'-azido-2',3'-dideoxy-5-methylcytidineRelated Search:

5-Methylcytidine 5-Methyluridine

  • 3'-azido-2',3'-dideoxy-5-methylcytidine
  • 3'-Azido-2',3'-dideoxy-4-deoxo-4-imino-5-methyluridine
  • CS-92
  • AzddMeC
  • Az-Dcme
  • Azidodideoxymethylcytidine
  • 3’-Azido-2’,3’-dideoxy-5-methyl cytidine, AzddMC
  • 87190-79-2