PC 766B
- Product Name
- PC 766B
- CAS No.
- 108375-77-5
- Chemical Name
- PC 766B
- Synonyms
- PC 766B;Oxacyclohexadeca-3,5,11,13-tetraen-2-one, 16-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[(2,6-dideoxy-β-D-arabino-hexopyranosyl)oxy]tetrahydro-2-hydroxy-5-methyl-6-[(1E,3E)-1,3-pentadien-1-yl]-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-, (3Z,5E,7R,8S,9S,11E,13E,15S,16R...
- CBNumber
- CB31333205
- Molecular Formula
- C43H68O12
- Formula Weight
- 776.99
- MOL File
- 108375-77-5.mol
PC 766B Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- solid
N-Bromosuccinimide Price
- Product number
- 20587
- Product name
- PC-766B
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $275
- Updated
- 2024/03/01
- Product number
- 20587
- Product name
- PC-766B
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $1026
- Updated
- 2024/03/01
- Product number
- P216603
- Product name
- PC-766B
- Packaging
- 1mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- P216603
- Product name
- PC-766B
- Packaging
- 2.5mg
- Price
- $385
- Updated
- 2021/12/16
- Product number
- C4269
- Product name
- PC-766B
- Packaging
- 1mg
- Price
- $312
- Updated
- 2021/12/16
PC 766B Chemical Properties,Usage,Production
Description
PC-766B is a macrolide antibiotic produced by N. brasiliensis that is active against Gram-positive bacteria and some fungi, yet inactive against Gram-negative bacteria. It also demonstrates antitumor activity against mouse P388 leukemia and B16 melanoma cells in vitro (IC50s = 0.1 and 0.4 ng/ml, respectively) and in vivo, but weakly inhibits the Na+,K+-ATPase compared to structurally related antibiotics.
Uses
PC-766B is a 16-membered macrolide antibiotic produced by Nocardia brasiliensis, reported by researchers at Sumitomo in 1993. Structurally, PC-766B is a member of bafilomycin class, featuring a rare butadiene side-chain. PC-766B is active against Gram positive bacteria, and some fungi and yeasts, but is inactive against Gram negative bacteria. It shows activity against murine tumor cells in vitro and in vivo, and weak inhibitory activity against Na/K-ATPase in vitro.
Uses
PC-766B is an antibiotic with activity against gram positive bacteria and some fungi and yeasts.
IC 50
Macrolide
References
[1] kumagai k, taya k, fukui a, et al. pc-766b, a new macrolide antibiotic produced by nocardia brasiliensis[j]. the journal of antibiotics, 1993, 46(6): 972-978.
PC 766B Preparation Products And Raw materials
Raw materials
Preparation Products
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