BETA-CYANO-L-ALANINE

Product Name: BETA-CYANO-L-ALANINE
CAS No.: 6232-19-5
Chemical Name: BETA-CYANO-L-ALANINE
Synonyms: H-CPA-OH;3-CYANO-L-ALANINE;(S)-2-Amino-3-cyanopropanoic acid;L-CNAla;H-ALA(3-CN)-OH;H-b-Cyano-Ala-OH;H-β-Cyano-Ala-OH;β-Cyano-L-Ala-OH;B-cyano-L-alanine;H-ALA(BETA-CN)-OH
CBNumber: CB3134375
Molecular Formula: C4H6N2O2
Formula Weight: 114.1
MOL File: 6232-19-5.mol

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BETA-CYANO-L-ALANINE Property

Melting point:: 217 °C
storage temp.: -20°C
solubility: PBS (pH 7.2): 10 mg/ml
form: A crystalline solid
color: White to yellow

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C9650
Product name: β-Cyano-L-alanine
Purity: ≥95%
Packaging: 250mg
Price: $628
Updated: 2025/07/31

Cayman Chemical

Product number: 10010947
Product name: β-cyano-L-Alanine
Purity: ≥98%
Packaging: 10mg
Price: $9
Updated: 2024/03/01

Cayman Chemical

Product number: 10010947
Product name: β-cyano-L-Alanine
Purity: ≥98%
Packaging: 50mg
Price: $30
Updated: 2024/03/01

Cayman Chemical

Product number: 10010947
Product name: β-cyano-L-Alanine
Purity: ≥98%
Packaging: 100mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 10010947
Product name: β-cyano-L-Alanine
Purity: ≥98%
Packaging: 250mg
Price: $109
Updated: 2024/03/01

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BETA-CYANO-L-ALANINE Chemical Properties,Usage,Production

Description

Hydrogen sulfide (H₂S) is a naturally-occurring gasotransmitter with vasodilator and inflammatory modulating activity. H₂S is synthesized naturally in a range of mammalian tissues principally by the activity of two enzymes, cystathionine γ lyase (CSE) and cystathionine β synthetase (CBS). β-cyano-L-Alanine (BCA) is a reversible inhibitor of the H₂S-synthesizing enzyme CSE. BCA blocks H₂S synthesis in rat liver preparations with an IC₅₀ value of 6.5 μM and increases blood pressure in anaesthetized rats induced with hemorrhagic shock by inhibiting endogenous H₂S synthesis. BCA at 50 mg/kg blocked both L-cysteine- and LPS-induced hyperalgesia in rats.

Chemical Properties

White to off-white powder

Uses

β-L-cyanoalanine is an amino acid that promotes seed germination in A. albus seeds. Beta-Cyano-L-alanine in the diet of adult locusts causes a decrease in the hemolymph volume thereby affecting water balance responses. L-β-cyanoalanine is an inhibitor of vitamin B6.

Definition

ChEBI: A cyanoamino acid that is the 3-cyano-derivative of L-alanine.

Biochem/physiol Actions

β-Cyano-L-alanine (BCA) is used as a cystathione γ-lyase (CSE) inhibitor to study the physiological roles of hydrogen sulfide in processes such as angiogenesis and hypertension.

References

[1] L LI P K M. Putative biological roles of hydrogen sulfide in health and disease: a breath of not so fresh air?[J]. Trends in pharmacological sciences, 2008, 29 2: 84-90. DOI: 10.1016/j.tips.2007.11.003
[2] WANG R. Two’s company, three’s a crowd: can H2S be the third endogenous gaseous transmitter?[J]. FASEB Journal, 2002, 16 13: 1792-1798. DOI: 10.1096/fj.02-0211hyp
[3] MORRIS PFEFFER Charlotte R. β-Cyanoalanine, an inhibitor of rat liver cystathionase[J]. Biochemical pharmacology, 1967, 16 12: Pages 2299-2308. DOI: 10.1016/0006-2952(67)90217-1
[4] YING-YUAN PAMELA MOK. Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis[J]. British Journal of Pharmacology, 2009, 143 7: 881-889. DOI: 10.1038/sj.bjp.0706014
[5] ATSUFUMI KAWABATA . Hydrogen sulfide as a novel nociceptive messenger[J]. PAIN?, 2007, 132 1: Pages 74-81. DOI: 10.1016/j.pain.2007.01.026

BETA-CYANO-L-ALANINE Preparation Products And Raw materials

Raw materials

Preparation Products

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BETA-CYANO-L-ALANINE Suppliers

China 50 Germany 1 India 3 Japan 1 Switzerland 2 United Kingdom 2 United States 14 Global 73

3B Pharmachem (Wuhan) International Co.,Ltd.

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Chemsky (shanghai) International Co.,Ltd

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9ding chemical ( Shanghai) Limited

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Guangzhou Isun Pharmaceutical Co., Ltd

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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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Sigma-Aldrich

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BOC Sciences

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Shanghai GL Peptide Ltd.

Tel: +86-21-61263340; 17609490614 13764994101
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
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6232-19-5, BETA-CYANO-L-ALANINERelated Search:

L-Tryptophan Dodecyl acrylate L-Isoleucine N-ALPHA-T-BUTOXYCARBONYL-BETA-CYANO-D-ALANINE,BOC-BETA-CYANO-D-ALANINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-BETA-CYANO-D-ALANINE BOC-BETA-CYANO-DL-ALANINE FMOC-BETA-CYANO-L-ALANINE,N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-BETA-CYANO-L-ALANINE N-ALPHA-CARBOBENZOXY-BETA-CYANO-L-ALANINE N-ALPHA-T-BUTOXYCARBONYL-BETA-CYANO-L-ALANINE,BOC-BETA-CYANO-L-ALANINE BETA-CYANO-L-ALANINE H-GLY-GLU-PNA

H-ALA(3-CN)-OH

H-ALA(BETA-CN)-OH

H-BETA-CYANO-ALA-OH

H-BETA-CYANO-L-ALA-OH

BETA-CYANO-ALANINE

BETA-CYANO-L-ALANINE

3-CYANO-L-ALANINE

B-cyano-L-alanine

H-CPA-OH

(2S)-2-amino-3-cyanopropanoic acid

(S)-2-Amino-3-cyanopropanoic acid

H-b-Cyano-Ala-OH

[S,(-)]-3-Cyano-2-aminopropionic acid

L-CNAla

H-β-Cyano-Ala-OH

β-Cyano-L-alanine≥ 98% (TLC)

β-Cyano-L-Ala-OH

L-Alanine, 3-cyano-

β-cyano-L-Alanine

inhibit,β cyano L Alanine,βcyanoLAlanine,Endogenous Metabolite,Inhibitor

β-Cyano-<sc>L</sc>-alanine

6232-19-5

Biochemicals and Reagents

A - H

Amino Acids and Peptides

BioChemical

Modified Amino Acids

A - H

Amino Acids

Modified Amino Acids