monazomycin

Product Name: monazomycin
CAS No.: 11006-31-8
Chemical Name: monazomycin
Synonyms: monazomycin;Monazomycin DISCONTINUED;Oxacyclooctatetraconta-13,17,21,29-tetraen-2-one, 48-(7-amino-1-methylheptyl)-8,10,16,20,24,26,28,32,36,38,40,42,44,46-tetradecahydroxy-23-(α-D-mannopyranosyloxy)-9,15,17,19,21,25,31,33,39,41,47-undecamethyl-
CBNumber: CB31349624
Molecular Formula: C72H133NO22
Formula Weight: 1364.82
MOL File: 11006-31-8.mol

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monazomycin Property

Melting point:: 127°C
Boiling point:: 866.56°C (rough estimate)
Density: 0.9708 (rough estimate)
refractive index: 1.5280 (estimate)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: solid
pka: 12.89±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20589
Product name: Monazomycin
Purity: ≥95%
Packaging: 1mg
Price: $364
Updated: 2024/03/01

Cayman Chemical

Product number: 20589
Product name: Monazomycin
Purity: ≥95%
Packaging: 5mg
Price: $908
Updated: 2024/03/01

ApexBio Technology

Product number: C4200
Product name: Monazomycin
Packaging: 5mg
Price: $1351
Updated: 2021/12/16

ApexBio Technology

Product number: C4200
Product name: Monazomycin
Packaging: 1mg
Price: $415
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0013163
Product name: MONAZOMYCIN
Purity: 95.00%
Packaging: 5MG
Price: $499.9
Updated: 2021/12/16

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monazomycin Chemical Properties,Usage,Production

Uses

Monazomycin is a macrocylic polyol lactone isolated from several species of Streptoverticillium, first reported in 1963. Monazomycin is active against Gram positive bacteria with weak Gram negative activity. In solution, monazomycin exists as hydrophilic clusters which, when adsorbed onto a lipid bilayer, can induce channel formation. Monazomycin is an important bioprobe for understanding membrane channels.

Uses

Monazomycin is a macrocyclic polyol lactone antibiotic isolated from Streptoverticilium.

Biological Activity

monazomycin is a positively charged and polyenelike antibiotic produced by streptomyces [1].monazomycin is able to induce a voltage-dependent conductance in lipid bilayer membranes. monazomycin is selective for monovalent cations and can alter the membrane conductance when applied to one or both sides of the membrane [1]. application of micromolar amounts of monazomycin on one side of phospholipid bilayer membranes induced dramatic voltage-dependent conductance effects. the steady-state conductance was proportional to the 5th power of the monazomycin concentration and increased exponentially with positive voltage (monazomycin side positive); there was an e-fold change in conductance per 4–6 mv. the major current-carrying ions were univalent cations. monazomycin monomers cooperated to form a multimolecular conductance channel. the voltage control of conductance arose from the electric field driving monazomycin molecules at the membrane surface into the membrane and thus affecting the number of channels that were formed [2].

References

[1] bamberg e, janko k. single channel conductance at lipid bilayer membranes in presence of monazomycin[j]. biochimica et biophysica acta (bba)-biomembranes, 1976, 426(3): 447-450.
[2] muller r u, finkelstein a. voltage-dependent conductance induced in thin lipid membranes by monazomycin[j]. the journal of general physiology, 1972, 60(3): 263-284.

monazomycin Preparation Products And Raw materials

Raw materials

Preparation Products

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monazomycin Suppliers

China 11 India 1 United Kingdom 1 United States 3 Global 16

Lynnchem

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Energy Chemical

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Shanghai Saikerui Biotechnology Co. , Ltd.

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11006-31-8, monazomycinRelated Search:

2,6,10-TRIMETHYL-5,9-UNDECADIEN-1-OL ALLYL-ALPHA-D-MANNOPYRANOSIDE 2,4-DIMETHYL-2,6-HEPTADIEN-1-OL monazomycin

monazomycin

Oxacyclooctatetraconta-13,17,21,29-tetraen-2-one, 48-(7-amino-1-methylheptyl)-8,10,16,20,24,26,28,32,36,38,40,42,44,46-tetradecahydroxy-23-(α-D-mannopyranosyloxy)-9,15,17,19,21,25,31,33,39,41,47-undecamethyl-

Monazomycin DISCONTINUED

11006-31-8

C72H133NO22