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monazomycin

Product Name
monazomycin
CAS No.
11006-31-8
Chemical Name
monazomycin
Synonyms
monazomycin;Monazomycin DISCONTINUED;Oxacyclooctatetraconta-13,17,21,29-tetraen-2-one, 48-(7-amino-1-methylheptyl)-8,10,16,20,24,26,28,32,36,38,40,42,44,46-tetradecahydroxy-23-(α-D-mannopyranosyloxy)-9,15,17,19,21,25,31,33,39,41,47-undecamethyl-
CBNumber
CB31349624
Molecular Formula
C72H133NO22
Formula Weight
1364.82
MOL File
11006-31-8.mol
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monazomycin Property

Melting point:
127°C
Boiling point:
866.56°C (rough estimate)
Density 
0.9708 (rough estimate)
refractive index 
1.5280 (estimate)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
solid
pka
12.89±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20589
Product name
Monazomycin
Purity
≥95%
Packaging
1mg
Price
$364
Updated
2024/03/01
Cayman Chemical
Product number
20589
Product name
Monazomycin
Purity
≥95%
Packaging
5mg
Price
$908
Updated
2024/03/01
ApexBio Technology
Product number
C4200
Product name
Monazomycin
Packaging
5mg
Price
$1351
Updated
2021/12/16
ApexBio Technology
Product number
C4200
Product name
Monazomycin
Packaging
1mg
Price
$415
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0013163
Product name
MONAZOMYCIN
Purity
95.00%
Packaging
5MG
Price
$499.9
Updated
2021/12/16
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monazomycin Chemical Properties,Usage,Production

Uses

Monazomycin is a macrocylic polyol lactone isolated from several species of Streptoverticillium, first reported in 1963. Monazomycin is active against Gram positive bacteria with weak Gram negative activity. In solution, monazomycin exists as hydrophilic clusters which, when adsorbed onto a lipid bilayer, can induce channel formation. Monazomycin is an important bioprobe for understanding membrane channels.

Uses

Monazomycin is a macrocyclic polyol lactone antibiotic isolated from Streptoverticilium.

Biological Activity

monazomycin is a positively charged and polyenelike antibiotic produced by streptomyces [1].monazomycin is able to induce a voltage-dependent conductance in lipid bilayer membranes. monazomycin is selective for monovalent cations and can alter the membrane conductance when applied to one or both sides of the membrane [1]. application of micromolar amounts of monazomycin on one side of phospholipid bilayer membranes induced dramatic voltage-dependent conductance effects. the steady-state conductance was proportional to the 5th power of the monazomycin concentration and increased exponentially with positive voltage (monazomycin side positive); there was an e-fold change in conductance per 4–6 mv. the major current-carrying ions were univalent cations. monazomycin monomers cooperated to form a multimolecular conductance channel. the voltage control of conductance arose from the electric field driving monazomycin molecules at the membrane surface into the membrane and thus affecting the number of channels that were formed [2].

References

[1] bamberg e, janko k. single channel conductance at lipid bilayer membranes in presence of monazomycin[j]. biochimica et biophysica acta (bba)-biomembranes, 1976, 426(3): 447-450.
[2] muller r u, finkelstein a. voltage-dependent conductance induced in thin lipid membranes by monazomycin[j]. the journal of general physiology, 1972, 60(3): 263-284.

monazomycin Preparation Products And Raw materials

Raw materials

Preparation Products

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11006-31-8, monazomycinRelated Search:


  • monazomycin
  • Oxacyclooctatetraconta-13,17,21,29-tetraen-2-one, 48-(7-amino-1-methylheptyl)-8,10,16,20,24,26,28,32,36,38,40,42,44,46-tetradecahydroxy-23-(α-D-mannopyranosyloxy)-9,15,17,19,21,25,31,33,39,41,47-undecamethyl-
  • Monazomycin DISCONTINUED
  • 11006-31-8
  • C72H133NO22