ChemicalBook > CAS DataBase List > MKT 077

MKT 077

Product Name: MKT 077
CAS No.: 147366-41-4
Chemical Name: MKT 077
Synonyms: FJ 776;MKT 077;MKT-077, ≥98% (HPLC);MKT077;MKT-077;FJ-776;MKT-077, 10 mM in DMSO;MKT-077 >=98% (HPLC), powder;MKT-077,Heat shock proteins,FJ 776,HSP,Inhibitor,inhibit,FJ776;1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride;Pyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (1:1);1-Ethyl-2-((Z)-((Z)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium chloride
CBNumber: CB31356358
Molecular Formula: C21H22ClN3OS2
Formula Weight: 432.00188
MOL File: 147366-41-4.mol

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MKT 077 Property

storage temp.: 2-8°C
solubility: H2O: soluble10mg/mL, clear
form: powder
color: orange to red
Water Solubility: H2O: 10mg/mL, clear

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Safety

WGK Germany: 3
RTECS: UU4023332
Toxicity: LD50 intraperitoneal in mouse: 50mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M5449
Product name: MKT-077
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $190
Updated: 2025/07/31

Sigma-Aldrich

Product number: M5449
Product name: MKT-077
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $398
Updated: 2025/07/31

Cayman Chemical

Product number: 14395
Product name: MKT-077
Purity: ≥95%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 14395
Product name: MKT-077
Purity: ≥95%
Packaging: 5mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 14395
Product name: MKT-077
Purity: ≥95%
Packaging: 10mg
Price: $162
Updated: 2024/03/01

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MKT 077 Chemical Properties,Usage,Production

Description

MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC₅₀s = 1.4-2.2 μM in vitro) through its ability to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones. It has been shown to bind to an allosteric site conserved in Hsp70 family members, interfering with ATP hydrolysis and abrogating the interaction of the chaperone with the tumor suppressor p53.

Uses

MKT-077 is used in the treatment of Alzheimer’s diseases and other tauopathie’s. Also, is a rhodacyanine derivative that selectively targets cancer cells and overcomes tamoxifen resistance

Biochem/physiol Actions

MKT-077 is an inhibitor of mitochondrial hsp70 family member, mortalin (mot-2)n; causes selective death of cancer cells.

in vivo

Systemic administration of MKT-077 significantly delays the growth of TT xenografts in mice throughout the treatment. At the end of MKT-077 treatment, it is found that tumor weights are about two-times less in MKT-077-treated group than in control group. MKT-077 treatment also results in weight loss and general toxicity in animals^[1]. Results show that the succinate-induced, ADP-stimulated respiratory rate in mitochondria isolated from the liver of rats treated with a bolus i.v. injection of 15 mg MKT-077 1kg body weight each day for 5 days is significantly lower than that of untreated controls^[3].

IC 50

HSP70

storage

Store at +4°C

References

[1] XIAOKAI LI. Analogues of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, As Anti-Cancer Agents[J]. ACS Medicinal Chemistry Letters, 2013, 4 11: 1042-1047. DOI: 10.1021/ml400204n
[2] AIKATERINI ROUSAKI . Allosteric Drugs: The Interaction of Antitumor Compound MKT-077 with Human Hsp70 Chaperones[J]. Journal of Molecular Biology, 2011, 411 3: Pages 614-632. DOI: 10.1016/j.jmb.2011.06.003
[3] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.

MKT 077 Preparation Products And Raw materials

Raw materials

Preparation Products

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MKT 077 Suppliers

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View Lastest Price from MKT 077 manufacturers

Career Henan Chemical Co

Product: MKT 077 147366-41-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-26

147366-41-4, MKT 077Related Search:

MKT 077

FJ 776

1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride

MKT077;MKT-077;FJ-776

Pyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (1:1)

MKT-077 >=98% (HPLC), powder

1-Ethyl-2-((Z)-((Z)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium chloride

MKT-077, ≥98% (HPLC)

MKT-077,Heat shock proteins,FJ 776,HSP,Inhibitor,inhibit,FJ776

MKT-077, 10 mM in DMSO

147366-41-4

C21H22ClN3OS2