MKT 077

Product Name: MKT 077
CAS No.: 147366-41-4
Chemical Name: MKT 077
Synonyms: FJ 776;MKT 077;MKT-077, ≥98% (HPLC);MKT077;MKT-077;FJ-776;MKT-077, 10 mM in DMSO;MKT-077 >=98% (HPLC), powder;MKT-077,Heat shock proteins,FJ 776,HSP,Inhibitor,inhibit,FJ776;1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride;Pyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (1:1);1-Ethyl-2-((Z)-((Z)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium chloride
CBNumber: CB31356358
Molecular Formula: C21H22ClN3OS2
Formula Weight: 432.00188
MOL File: 147366-41-4.mol

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MKT 077 Property

storage temp.: 2-8°C
solubility: H2O: soluble10mg/mL, clear
form: powder
color: orange to red
Water Solubility: H2O: 10mg/mL, clear

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Safety

WGK Germany: 3
RTECS: UU4023332
Toxicity: LD50 intraperitoneal in mouse: 50mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M5449
Product name: MKT-077
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $195
Updated: 2024/03/01

Sigma-Aldrich

Product number: M5449
Product name: MKT-077
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $309.6
Updated: 2024/03/01

Cayman Chemical

Product number: 14395
Product name: MKT-077
Purity: ≥95%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 14395
Product name: MKT-077
Purity: ≥95%
Packaging: 5mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 14395
Product name: MKT-077
Purity: ≥95%
Packaging: 10mg
Price: $162
Updated: 2024/03/01

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MKT 077 Chemical Properties,Usage,Production

Description

MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC₅₀s = 1.4-2.2 μM in vitro) through its ability to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones. It has been shown to bind to an allosteric site conserved in Hsp70 family members, interfering with ATP hydrolysis and abrogating the interaction of the chaperone with the tumor suppressor p53.

Uses

MKT-077 is used in the treatment of Alzheimer’s diseases and other tauopathie’s. Also, is a rhodacyanine derivative that selectively targets cancer cells and overcomes tamoxifen resistance

Biochem/physiol Actions

MKT-077 is an inhibitor of mitochondrial hsp70 family member, mortalin (mot-2)n; causes selective death of cancer cells.

storage

Store at +4°C

MKT 077 Preparation Products And Raw materials

Raw materials

Preparation Products

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MKT 077 Suppliers

China 63 India 3 United Kingdom 1 United States 10 Global 77

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4727
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 5944
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29764
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

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View Lastest Price from MKT 077 manufacturers

Career Henan Chemical Co

Product: MKT 077 147366-41-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-26

147366-41-4, MKT 077Related Search:

MKT 077

FJ 776

1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride

MKT077;MKT-077;FJ-776

Pyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (1:1)

MKT-077 >=98% (HPLC), powder

1-Ethyl-2-((Z)-((Z)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium chloride

MKT-077, ≥98% (HPLC)

MKT-077,Heat shock proteins,FJ 776,HSP,Inhibitor,inhibit,FJ776

MKT-077, 10 mM in DMSO

147366-41-4

C21H22ClN3OS2